Search Results - "Klodowska, Gabriela"

CARD15 variants in patients with sporadic Parkinson's disease by Bialecka, Monika, Kurzawski, Mateusz, Klodowska-Duda, Gabriela, Opala, Grzegorz, Juzwiak, Stefania, Kurzawski, Grzegorz, Tan, Eng-King, Drozdzik, Marek

“…Recent reports have proven the importance of genetic factors and inflammation in the pathogenesis of sporadic Parkinson's disease (PD). In the current study,…”
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Safety and tolerability of inebilizumab (MEDI-551), an anti-CD19 monoclonal antibody, in patients with relapsing forms of multiple sclerosis: Results from a phase 1 randomised, placebo-controlled, escalating intravenous and subcutaneous dose study by Agius, Mark A, Klodowska-Duda, Gabriela, Maciejowski, Maciej, Potemkowski, Andrzej, Li, Jing, Patra, Kaushik, Wesley, Jacob, Madani, Soraya, Barron, Gerard, Katz, Eliezer, Flor, Armando

“…Background: B cells may be involved in the pathophysiology of multiple sclerosis (MS). Inebilizumab (formerly MEDI-551) binds to and depletes CD19+ B cells…”
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Frequency of mutations in PRKN, PINK1, and DJ1 in Patients With Early-Onset Parkinson Disease from neighboring countries in Central Europe by Milanowski, Łukasz M., Lindemann, Jennifer A., Hoffman-Zacharska, Dorota, Soto-Beasley, Alexandra I., Barcikowska, Maria, Boczarska-Jedynak, Magdalena, Deutschlander, Angela, Kłodowska, Gabriela, Dulski, Jarosław, Fedoryshyn, Lyuda, Friedman, Andrzej, Jamrozik, Zygmunt, Janik, Piotr, Karpinsky, Katherine, Koziorowski, Dariusz, Krygowska-Wajs, Anna, Jasińska-Myga, Barbara, Opala, Grzegorz, Potulska-Chromik, Anna, Pulyk, Aleksander, Rektorova, Irena, Sanotsky, Yanosh, Siuda, Joanna, Sławek, Jarosław, Śmiłowska, Katarzyna, Szczechowski, Lech, Rudzińska-Bar, Monika, Walton, Ronald L., Ross, Owen A., Wszolek, Zbigniew K.

“…Approximately 10% of patients with Parkinson disease (PD) present with early-onset disease (EOPD), defined as diagnosis before 50 years of age. Genetic factors…”
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Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial by Teng, Edmond, Manser, Paul T, Pickthorn, Karen, Brunstein, Flavia, Blendstrup, Mira, Sanabria Bohorquez, Sandra, Wildsmith, Kristin R, Toth, Bali, Dolton, Michael, Ramakrishnan, Vidya, Bobbala, Ashwini, Sikkes, Sietske A M, Ward, Michael, Fuji, Reina N, Kerchner, Geoffrey A

“…Neurofibrillary tangles composed of aggregated tau protein are one of the neuropathological hallmarks of Alzheimer disease (AD) and correlate with clinical…”
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Analysis of MDR1 haplotypes in Parkinson's disease in a white population by Tan, Eng-King, Drozdzik, Marek, Bialecka, Monika, Honczarenko, Krystyna, Klodowska-Duda, Gabriela, Teo, Y.Y., Tang, Kun, Wong, Li-Peng, Chong, Samuel S., Tan, Chris, Yew, Kenneth, Zhao, Yi, Lee, Caroline GL

“…The MDR1 multidrug transporter is important in regulating environmental xenobiotics and hence may play a causative role in Parkinson's disease (PD). MDR1…”
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Frequency of Mutations in PRKN, PINK1, and DJ1 in Patients With Early-Onset Parkinson Disease From Neighboring Countries in Central Europea by Milanowski, Lukasz M., Lindemann, Jennifer A., Hoffman-Zacharska, Dorota, Soto-Beasley, Alexandra I., Barcikowska, Maria, Boczarska-Jedynak, Magdalena, Deutschlander, Angela, Klodowska, Gabriela, Dulski, Jaroslaw, Fedoryshyn, Lyuda, Friedman, Andrzej, Jamrozik, Zygmunt, Janik, Piotr, Karpinsky, Katherine, Koziorowski, Dariusz, Krygowska-Wajs, Anna, Jasinska-Myga, Barbara, Opala, Grzegorz, Potulska-Chromik, Anna, Pulyk, Aleksander, Rektorova, Irena, Sanotsky, Yanosh, Siuda, Joanna, Slawek, Jaroslaw, Smilowska, Katarzyna, Szczechowski, Lech, Rudzinska-Bar, Monika, Walton, Ronald L., Ross, Owen A., Wszolek, Zbigniew K.

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The role of estrogens in Parkinson's disease by Dziedziejko, Violetta, Białecka, Monika, Machoy-Mokrzyńska, Anna, Kłodowska-Duda, Gabriela, Chlubek, Dariusz

“…Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder of the central nervous system. It has a high prevalence, which significantly…”
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Pharmacogenetics in Parkinson's disease treatment by Białecka, Monika, Kłodowska-Duda, Gabriela, Kurzawski, Mateusz, Droździk, Marek

“…The authors present the current opinion on the significance of molecular biology in individualized therapy. Pharmacogenetics is a new branch of clinical…”
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Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension by Kapoor, Raju, Chang, Ih, Deykin, Aaron, Forrestal, Fiona, Lucas, Nisha, Yu, Bei, Arnold, Douglas L, Freedman, Mark S, Hartung, Hans-Peter, Jeffery, Douglas, Sellebjerg, Finn, Cadavid, Diego, Mikol, Dan, Bartholomé, Emmanuel, D'Hooghe, Marie, Devonshire, Virginia, Grand'Maison, François, Jacques, François, Lapierre, Yves, Morrow, Sarah, Stetkarova, Ivana, Talabova, Marika, Frederiksen, Jette, Kant, Matthias, Petersen, Thor, Eralinna, Juha-Pekka, Brassat, David, Brochet, Bruno, Vermersch, Patrick, Vukusi, Sandra, Baum, Karl, Maeurer, Mathias, Meuth, Sven, Hardiman, Orla, Achiron, Anat, Karussis, Dimitrios, Bergamaschi, Roberto, Grimaldi, Luigi, Salvetti, Marco, Scarpini, Elio, Sola, Patrizia, Zaffaroni, Mauro, Frequin, Stephan, Hupperts, Raymond, Killestein, Joep, Schrijver, Hans, van Munster, Erik, Drozdowski, Wieslaw, Fryze, Waldemar, Klodowska-Duda, Gabriela, Motta, Ewa, Podemski, Ryszard, Selmaj, Krzysztof, Stepien, Adam, Tutaj, Andrzej, Boyko, Alexey, Escartin, Antonio, Garcia-Merino, Antonio, Hernandez Perez, Miguel Angel, Ayuso, Guillermo Izquierdo, Lallana, José Meca, Gairin, Xavier Montalban, Gunnarsson, Martin, Roshanisefat, Homayoun, Sundstrom, Peter, Gran, Bruno, Kapoor, Raju, Mattison, Paul, Pearson, Owen, Rashid, Waqar, Rog, David, Silber, Eli, Bandari, Daniel, Camac, Ann, Cohan, Stanley, Fabian, Michelle, Florin, Jack, Freedman, Steven, Garwacki, Dennis, Goldman, Myla, Harrison, Daniel, Herrman, Craig, Huang, Deren, Jeffery, Douglas, Kamin, Stephen, Langer-Gould, Annette, Mattson, David, Miller, Tamara, Moses, Harold, Muley, Suraj, Nielsen, Allen, Pardo, Gabriel, Picone, MaryAnn, Robertson, Derrick, Sheppard, Christopher, Thrower, Ben, Twyman, Cary, Waubant, Emmanuelle, Yadav, Vijayshree, Zabad, Rana

“…Although several disease-modifying treatments are available for relapsing multiple sclerosis, treatment effects have been more modest in progressive multiple…”
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Catechol-O-methyltransferase and monoamine oxidase B genes and susceptibility to sporadic Parkinson's disease in a Polish population by Białecka, Monika, Droździk, Marek, Honczarenko, Krystyna, Gawrońska-Szklarz, Barbara, Stankiewicz, Jan, Dabrowska, Ewa, Kubisiak, Maciej, Kłodowska-Duda, Gabriela, Opala, Grzegorz

“…Recent reports have proved that genetic factors play a role in the pathogenesis of sporadic Parkinson's disease (PD). It has been suggested that polymorphisms…”
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Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY): a randomised, placebo-controlled, phase 2 trial by Cadavid, Diego, Mellion, Michelle, Hupperts, Raymond, Edwards, Keith R, Calabresi, Peter A, Drulović, Jelena, Giovannoni, Gavin, Hartung, Hans-Peter, Arnold, Douglas L, Fisher, Elizabeth, Rudick, Richard, Mi, Sha, Chai, Yi, Li, Jie, Zhang, Yiwei, Cheng, Wenting, Xu, Lei, Zhu, Bing, Green, Susan M, Chang, Ih, Deykin, Aaron, Sheikh, Sarah I, Agüera Morales, Eduardo, Al Khedr, Abdullatif, Ampapa, Radek, Arroyo, Rafael, Belkin, Martin, Bonek, Robert, Boyko, Alexey, Capra, Ruggero, Centonze, Diego, Clavelou, Pierre, Debouverie, Marc, Drulovic, Jelena, Edwards, Keith, Evangelou, Nikos, Evdoshenko, Evgeniy, Fernández, Oscar, Fernández Sánchez, Victoria, Freedman, Mark, Freedman, Steven, Fryze, Waldemar, Garcia-Merino, Antonio, Gavric-Kezic, Mira, Ghezzi, Angel, Gout, Olivier, Grimaldi, Luigi, Hertmanowska, Hanka, Hintzen, Rogier, Hradilek, Pavel, Hupperts, Raymond, Ilkowski, Jan, Ivashinenkova, Evelina, Izquierdo, Guillermo, Jacques, Francois, Jakab, Gabor, Khabirov, Farit, Klodowska-Duda, Gabriela, Komoly, Samuel, Kostic, Smiljana, Kovarova, Ivana, Kremenchuzky, Marcelo, Laganke, Christopher, LaPierre, Yves, Maciejowski, Maciej, Maison, Francois Grand, Marfia, Girolama Alessandra, Martínez Yélamos, Sergio, Meluzinova, Eva, Montalban, Xavier, Murray, Ronald, Naismith, Robert, Newsome, Scott, Nguyen, Viet, Oreja, Delia, Pardo, Gabriel, Pasechnik, Elena, Patti, Francesco, Potemkowski, Andrzej, Prokopenko, Semen, Qian, Peiqing, Rodríguez-Antigüedad, Alfredo, Rossman, Howard, Rozsa, Csilla, Sánchez López, Fernando, Selmaj, Krzysztof, Silber, Eli, Stepien, Adam, Stepniewska, Anna, Swiat, Maciej, Toncev, Gordana, Tourbah, Ayman, Trushnikova, Tatyana, Uccelli, Antonio, Vachova, Marta, Valis, Martin, Vecsei, Laszlo, Wiertlewski, Sandrine, Zaffaroni, Mauro, Zielinski, Tomasz

“…Opicinumab is a human monoclonal antibody against LINGO-1, an inhibitor of oligodendrocyte differentiation and axonal regeneration. Previous findings suggested…”
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Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial by Espay, Alberto J, Stocchi, Fabrizio, Pahwa, Rajesh, Albanese, Alberto, Ellenbogen, Aaron, Ferreira, Joaquim J, Giladi, Nir, Gurevich, Tanya, Hassin-Baer, Sharon, Hernandez-Vara, Jorge, Isaacson, Stuart H, Kieburtz, Karl, LeWitt, Peter A, Lopez-Manzanares, Lydia, Olanow, C Warren, Poewe, Werner, Sarva, Harini, Yardeni, Tami, Adar, Liat, Salin, Laurence, Lopes, Nelson, Sasson, Nissim, Case, Ryan, Rascol, Olivier, Afshari, Mitra, Amelin, Alexander, Arkadir, David, Badarny, Samih, Balaguer Martinez, Ernest, Bogucki, Andrzej, Boyd, James, Buyan Dent, Laura, Carroll, Camille, Chaudhuri, Kallol Ray, Cooney, Jeffrey, Corbillé, Anne-Gaëlle, Danaila, Teodor, De Pandis, Maria Francesca, Dethy, Sophie, Dhall, Rohit, Djaldetti, Ruth, Durif, Franck, Flitman, Stephen, Freire Alvarez, Eric, Goudreau, John, Grandas Perez, Francisco, Gurevich, Tanya, Isa, Arnaldo, Juncos, Jorge L, Kanchana, Sulada, Klodowska-Duda, Gabriela, Koziorowski, Dariusz, Kulisevsky Bojarski, Jaime, Lopez Lozano, Juan, Luo, Lan, Lytvynenko, Nataliya, Marconi, Roberto, Marques, Ana-Raquel, Martinez Castrillo, Juan Carlos, Martinez Torres, Irene, Mentreddi, Aashoo, Mir Rivera, Pablo, Moskovko, Sergii, Neryanova, Yuliya, Onofrj, Marco, Ostrem, Jill, Pacchetti, Claudio, Pavese, Nicola, Pellicano, Clelia, Revuelta, Gonzalo, Rodrigues, Ana Margarida, Rodriguez, Ramon, Rudzinska, Monika, Sarwar, Nighat, Schwartzbard, Julie, Scorr, Laura, Slevin, John, Slobodin, Tatyana, Spalletta, Gianfranco, Tagliati, Michele, Tai, Yen, Tessitore, Alessandro, Valkovic, Peter, Verhagen, Leo, Vostrikova, Elena, Yahalom, Gilad, Zalyalova, Zuleykha, Zarubova, Katerina, Zhukova, Irina

“…Conventional oral levodopa therapy for the treatment of Parkinson's disease can be associated with variations in plasma concentrations. Levodopa infusion…”
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The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinsonʼs disease, levodopa treatment response, and complications by Bialecka, Monika, Kurzawski, Mateusz, Klodowska-Duda, Gabriela, Opala, Grzegorz, Tan, Eng-King, Drozdzik, Marek

“…INTRODUCTIONDifferences in catechol-O-methyltransferase (COMT) activity and genotype may determine individual variations in the therapeutic response to…”
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Association study of GATA-2 transcription factor gene ( GATA2 ) polymorphism and Parkinson's disease by Kurzawski, Mateusz, Białecka, Monika, Sławek, Jarosław, Kłodowska-Duda, Gabriela, Droździk, Marek

“…Abstract It was shown that high levels of α-synuclein in substantia nigra are essential in pathogenesis of Parkinson disease (PD), and SNCA expression in…”
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Mitochondrial transcription factor A variants and the risk of Parkinson's disease by Gaweda-Walerych, Katarzyna, Safranow, Krzysztof, Maruszak, Aleksandra, Bialecka, Monika, Klodowska-Duda, Gabriela, Czyzewski, Krzysztof, Slawek, Jaroslaw, Rudzinska, Monika, Styczynska, Maria, Opala, Grzegorz, Drozdzik, Marek, Kurzawski, Maciej, Szczudlik, Andrzej, Canter, Jeffrey A., Barcikowska, Maria, Zekanowski, Cezary

“…The mitochondrial transcription factor A (TFAM) has been recently shown to decrease reactive oxygen species (ROS) generation. It is also known that…”
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Mitochondrial DNA haplogroups and subhaplogroups are associated with Parkinson’s disease risk in a Polish PD cohort by Gaweda-Walerych, Katarzyna, Maruszak, Aleksandra, Safranow, Krzysztof, Bialecka, Monika, Klodowska-Duda, Gabriela, Czyzewski, Krzysztof, Slawek, Jaroslaw, Rudzinska, Monika, Styczynska, Maria, Opala, Grzegorz, Drozdzik, Marek, Canter, Jeffrey A., Barcikowska, Maria, Zekanowski, Cezary

“…mtDNA common variation is inconsistently reported to modify the risk of Parkinson’s disease (PD). We evaluated the impact of the mitochondrial haplogroups,…”
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Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease by Adamiak, Urszula, Kaldonska, Maria, Klodowska-Duda, Gabriela, Wyska, Elzbieta, Safranow, Krzysztof, Bialecka, Monika, Gawronska-Szklarz, Barbara

“…The aims of the present study were to investigate the pharmacokinetic and pharmacodynamic (pk/pd) relationship of levodopa (l-dopa) in patients with advanced…”
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PARK2 variability in Polish Parkinson’s disease patients - interaction with mitochondrial haplogroups by Gaweda-Walerych, Katarzyna, Safranow, Krzysztof, Jasinska-Myga, Barbara, Bialecka, Monika, Klodowska-Duda, Gabriela, Rudzinska, Monika, Czyzewski, Krzysztof, Cobb, Stephanie A, Slawek, Jaroslaw, Styczynska, Maria, Opala, Grzegorz, Drozdzik, Marek, Nishioka, Kenya, Farrer, Matthew J, Ross, Owen A, Wszolek, Zbigniew K, Barcikowska, Maria, Zekanowski, Cezary

“…Abstract Aims and objectives A new pathomechanism of Parkinson’s disease (PD) involving regulation of mitochondrial functions was recently proposed. Parkin…”
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Analysis of LRRK2 G2019S and I2020T mutations in Parkinson's disease by Bialecka, Monika, Hui, Shen, Klodowska-Duda, Gabriela, Opala, Grzegorz, Tan, Eng-King, Drozdzik, Marek

“…Mutations in the leucine-rich repeat kinase 2 (LRRK2), encoding dardarin protein, have been demonstrated to be linked to autosomal dominant Parkinson's disease…”
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Association study of GATA-2 transcription factor gene (GATA2) polymorphism and Parkinson' s disease by Kurzawski, Mateusz, Bialecka, Monika, Slawek, Jaroslaw, Klodowska-Duda, Gabriela, Drozdzik, Marek

“…It was shown that high levels of a-synuclein in substantia nigra are essential in pathogenesis of Parkinson disease (PD), and SNCA expression in neurons is…”
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