Search Results - "Klobeck, G"

Deregulation of the proto-oncogene c-myc through t(8;22) translocation in Burkitt's lymphoma by GERBITZ, A, MAUTNER, J, GELTINGER, C, HÖRTNAGEL, K, CHRISTOPH, B, ASENBAUER, H, KLOBECK, G, POLACK, A, BORNKAMM, G

“…In Burkitt's lymphoma (BL) cells the proto-oncogene c-myc is juxtaposed to one of the immunoglobulin (Ig) loci on chromosomes 2, 14, or 22. The c-myc gene…”
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In vivo and in vitro analysis of the human tissue‐type plasminogen activator gene promoter in neuroblastomal cell lines: evidence for a functional upstream κB element by LUX, W., KLOBECK, H‐G., DANIEL, P. B., COSTA, M., MEDCALF, R. L., SCHLEUNING, W‐D.

“…Besides its well‐established role in wound healing and fibrinolysis, tissue‐type plasminogen activator (t‐PA) has been shown to contribute to cognitive…”
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V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism by Combriato, G, Klobeck, H G

“…We have cloned a region of 124 kb of the human immunoglobulin lambda light chain locus on chromosome 22 encompassing seven V lambda and seven J-C lambda gene…”
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Regulatory elements in the immunoglobulin kappa locus induce c‐myc activation and the promoter shift in Burkitt's lymphoma cells by Polack, A., Feederle, R., Klobeck, G., Hörtnagel, K.

“…In Burkitt's lymphoma cells the proto‐oncogene c‐myc is constantly juxtaposed through chromosomal translocation to one of the immunoglobulin loci on…”
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Immunophenotypic features and configuration of immunoglobulin genes in hairy cell leukemia-Japanese variant by Yamaguchi, M, Machii, T, Shibayama, H, Tokumine, Y, Hara, J, Yutsudo, M, Yamada, O, Klobeck, H G, Kitani, T

“…Immunophenotypes and Ig gene rearrangements were investigated in 12 patients with a variant form of hairy cell leukemia (HCL) termed HCL-Japanese variant…”
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Differential interactions between the immunoglobulin heavy chain mu intron and 3' enhancer by Mocikat, R, Kardinal, C, Klobeck, H G

“…The immunoglobulin heavy chain 3' enhancer may be a novel type of a transcriptional regulation element in as much as its function is position dependent. We…”
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Genomic sequence of human prostate specific antigen (PSA) by KLOBECK, H.-G, COMBRIATO, G, SCHULZ, P, FITTLER, F

“…A genomic clone of human Prostate Specific Antigen (PSA) was isolated from a cosmid library from the lymphoid cell line GM 607 and the PSA gene was completely…”
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Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence by SCHULZ, P, STUCKA, R, FELDMANN, H, COMBRIATO, G, KLOBECK, H.-G, FITTLER, F

“…A cDNA clone of human Prostate Specific Antigen (PSA) was isolated from a cDNA library in the expression vector lambda gt11. The library was constructed…”
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Cloning of the human α2-macroglobulin gene and detection of mutations in two functional domains : the bait region and the thiolester site by POLLER, W, FABER, J.-P, KLOBECK, G, OLEK, K

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The Human Replacement Histone H3.3B Gene (H3F3B) by Albig, Werner, Bramlage, Birgit, Gruber, Konstanze, Klobeck, Hans-Gustav, Kunz, Jürgen, Doenecke, Detlef

“…H3.3 is a replacement histone subtype that is encoded by two replication-independent genes termed H3.3A and H3.3B, respectively. We have isolated a full-size…”
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Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene by Klobeck, H.-Gustav, Bornkamm, Georg W., Combriato, Gabriele, Mocikat, Ralph, Pohlenz, Hans-Dieter, Zachau, Hans G.

“…The series of studies on the human K light chain genes of the various subgroups is concluded by this report on the isolation and nucleotide sequence…”
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Megabase inversions in the human genome as physiological events by Weichhold, Gottfried M, Klobeck, H.-Gustav, Ohnheiser, Rita, Combriato, Gabriele, Zachau, Hans G

“…The genes of the immunoglobulin kappa light chains are assembled during B-cell differentiation by somatic recombination of one of the V kappa (variable) gene…”
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Contribution of human V κ II germ-line genes to light-chain diversity by Klobeck, H.-G, Solomon, A, Zachau, H. G

“…The genetic basis of the antibody repertoire--estimated to exceed 10(6) different immunoglobulin molecules--is a major unanswered problem. The number of…”
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Human Immunoglobulin kappa light chain genes of subgroups II and III by Klobeck, H.-Gustav, Meindl, Alfons, Combriato, Gabriele, Solomon, Alan, Zachau, Hans G.

“…The first complete sequences of functionally rearranged VK genes (abbreviations ref.l) of subgroups II and III are reported. The genes have been cloned from…”
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The human CK gene segment and the kappa deleting element are closely linked by Klobeck, H.-Gustav, Zachau, Hans G.

“…The element which mediates the deletion of the CK gene segment (abbreviations ref. 1) in human γ light chain producing B-cells was found to be located 24 kb…”
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The chromosome 2 breakpoint in Burkitt lymphoma Ly66 lies between VK and JK by ADOLPH, S, HAMEISTER, H, KLOBECK, H.-G, ZACHAU, H. G

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Burkitt lymphoma in the mouse by Kovalchuk, A L, Qi, C F, Torrey, T A, Taddesse-Heath, L, Feigenbaum, L, Park, S S, Gerbitz, A, Klobeck, G, Hoertnagel, K, Polack, A, Bornkamm, G W, Janz, S, Morse, 3rd, H C

“…Chromosomal translocations juxtaposing the MYC protooncogene with regulatory sequences of immunoglobulin (Ig) H chain or kappa (Ig kappa) or lambda (Ig lambda)…”
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Linking of the human immunoglobulin VK and JKCK regions by chromosomal walking by KLOBECK, H.-G, ZIMMER, F.-J, COMBRIATO, G, ZACHAU, H. G

“…The linking of the human VK and JKCK gene regions (abbreviations in ref. 1) by chromosomal walking is reported. Hybridization experiments with the DNA of a…”
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The reciprocal recombination product of a VK-JK joining reaction remains on chromosome 2p12 by KLOBECK, H.-G, ADOLPH, S, HAMEISTER, H, ZACHAU, H. G

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N segment insertion and region-directed somatic hypermutation in a Kappa gene of a t(2;8) chromosomal translocation by KLOBECK, H.-G, COMBRIATO, G, ZACHAU, H. G

“…A detailed molecular analysis of both reciprocal recombination products of the variant t(2;8) chromosomal translocation of the Burkitt lymphoma derived cell…”
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