Search Results - "Klippel, J. H."

Combination therapy with pulse cyclophosphamide plus pulse methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis by ILLEI, Gabor G, AUSTIN, Howard A, KLIPPEL, John H, BALOW, James E, BOUMPAS, Dimitrios T, CRANE, Marianna, COLLINS, Lee, GOURLEY, Mark F, YARBORO, Cheryl H, VAUGHAN, Ellen M, KUROIWA, Takashi, DANNING, Carol L, STEINBERG, Alfred D

“…Controlled trials in lupus nephritis have demonstrated that cyclophosphamide therapy is superior to corticosteroid therapy alone. The long-term effectiveness…”
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Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis by Boumpas, D T, Austin, 3rd, H A, Vaughn, E M, Klippel, J H, Steinberg, A D, Yarboro, C H, Balow, J E

“…Pulse cyclophosphamide is more effective than prednisone alone in preventing renal failure in lupus nephritis. We undertook a randomised, controlled trial to…”
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Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis : A randomized, controlled trial by GOURLEY, M. F, AUSTIN, H. A, SCOTT, D, YARBORO, C. H, VAUGHAN, E. M, MUIR, J, BOUMPAS, D. T, KLIPPEL, J. H, BALOW, J. E, STEINBERG, A. D

“…Uncertainty exists about the efficacy and toxicity of bolus therapy with methylprednisolone or of the combination of methylprednisolone and cyclophosphamide in…”
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Biologic Therapy for Rheumatoid Arthritis by Klippel, John H

“…This year marks the 50th anniversary of the awarding of the Nobel Prize in Physiology and Medicine to Kendall, Hench, and Reichstein for the isolation and…”
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Long-term effects of combination treatment with fludarabine and low-dose pulse cyclophosphamide in patients with lupus nephritis by Illei, G. G., Yarboro, C. H., Kuroiwa, T., Schlimgen, R., Austin, H. A., Tisdale, J. F., Chitkara, P., Fleisher, T., Klippel, J. H., Balow, J. E., Boumpas, D. T.

“…Objectives. To determine the safety and efficacy of a short course of fludarabine combined with cyclophoshamide in lupus nephritis. Methods. A phase I/II open…”
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Risk for sustained amenorrhea in patients with systemic lupus erythematosus receiving intermittent pulse cyclophosphamide therapy by BOUMPAS, D. T, AUSTIN, H. A, VAUGHAN, E. M, YARBORO, C. H, KLIPPEL, J. H, BALOW, J. E

“…To determine the risk for secondary amenorrhea after pulse cyclophosphamide therapy in premenopausal women with systemic lupus erythematosus. Controlled,…”
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Recombinant human Dnase I (rhDNase) in patients with lupus nephritis by Davis, J C, Manzi, S, Yarboro, C, Rairie, J, Mcinnes, I, Averthelyi, D, Sinicropi, D, Hale, V G, Balow, J, Austin, H, Boumpas, D T, Klippel, J H

“…Systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies to nucleoprotein antigens, including double-stranded DNA…”
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Synovitis occurs in some clinically normal and asymptomatic joints in patients with early arthritis by Pando, J A, Duray, P, Yarboro, C, Gourley, M F, Klippel, J H, Schumacher, H R

“…To determine if clinically asymptomatic knee joints in patients with recent onset arthritis reveal histological evidence of synovitis. As part of a prospective…”
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Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs by Austin, 3rd, H A, Klippel, J H, Balow, J E, le Riche, N G, Steinberg, A D, Plotz, P H, Decker, J L

“…We evaluated renal function in 107 patients with active lupus nephritis who participated in long-term randomized therapeutic trials (median follow-up, seven…”
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Second-Line Drug Therapy for Rheumatoid Arthritis by Cash, Joseph M, Klippel, John H

“…Three major classes of drugs are used in the treatment of patients with rheumatoid arthritis: nonsteroidal antiinflammatory drugs, corticosteroids, and drugs…”
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Use of cytotoxic agents and cyclosporine in the treatment of autoimmune disease. Part 2 : Inflammatory bowel disease, systemic vasculitis, and therapeutic toxicity by LANGFORD, C. A, KLIPPEL, J. H, BALOW, J. E, JAMES, S. P, SNELLER, M. C

“…When cytotoxic agents were introduced, their ability to disrupt nucleic acid and protein synthesis led to their effective use for the treatment of neoplastic…”
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Update on cyclophosphamide for systemic lupus erythematosus by Ortmann, R A, Klippel, J H

“…Over the past decade cyclophosphamide has come to assume an increasingly prominent role in the management of severe, life-threatening manifestations of SLE…”
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Pulse cyclophosphamide for severe neuropsychiatric lupus by Boumpas, D T, Yamada, H, Patronas, N J, Scott, D, Klippel, J H, Balow, J E

“…We studied the effect of parenteral pulse cyclophosphamide therapy in nine patients with active systemic lupus erythematosus and severe central nervous system…”
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Winning the battle, losing the war? Another editorial about rheumatoid arthritis by Klippel, J H

“…Major advances in the therapy of RA will likely require future scientific breakthroughs in the understanding of pathophysiology. That is not to suggest that…”
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Use of cytotoxic agents and cyclosporine in the treatment of autoimmune disease. Part 1 : Rheumatologic and renal diseases by LANGFORD, C. A, KLIPPEL, J. H, BALOW, J. E, JAMES, S. P, SNELLER, M. C

“…When cytotoxic agents were initially introduced, their ability to disrupt nucleic acid and protein synthesis led to their effective use for the treatment of…”
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End-stage renal disease and systemic lupus erythematosus by Mojcik, C F, Klippel, J H

“…To provide an overview of the course of systemic lupus erythematosus (SLE) following the onset of end-stage lupus nephropathy, regarding clinical and…”
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Cyclosporin A in severe, treatment-refractory rheumatoid arthritis. A randomized study by Yocum, D E, Klippel, J H, Wilder, R L, Gerber, N L, Austin, 3rd, H A, Wahl, S M, Lesko, L, Minor, J R, Preuss, H G, Yarboro, C

“…To assess the efficacy and toxicity of cyclosporin A in patients with severe, treatment-refractory rheumatoid arthritis. Prospective randomized, double-blind…”
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Acute transverse myelitis in systemic lupus erythematosus: magnetic resonance imaging and review of the literature by Boumpas, D T, Patronas, N J, Dalakas, M C, Hakim, C A, Klippel, J H, Balow, J E

“…We describe a patient with systemic lupus erythematosus (SLE) who presented with acute transverse myelitis. Magnetic resonance imaging (MRI) of the cervical…”
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Incidence of cancer among men with the Felty syndrome by GRIDLEY, G, KLIPPEL, J. H, HOOVER, R. N, FRAUMENI, J. F

“…To estimate the incidence of cancer (especially lymphoproliferative malignancies) in patients with the Felty syndrome. A retrospective cohort study. A…”
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Angiotensin I converting enzyme gene polymorphisms in systemic lupus erythematosus: decreased prevalence of DD genotype in African American patients by Tassiulas, I O, Aksentijevich, I, Salmon, J E, Kim, Y, Yarboro, C H, Vaughan, E M, Davis, J C, Scott, D L, Austin, H A, Klippel, J H, Balow, J E, Gourley, M F, Boumpas, D T

“…The presence of the D (deletion) allele at the angiotensin converting enzyme (ACE) gene has been associated with a) adverse vascular events contributing to…”
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