Search Results - "Klippel, A"

Exploring the underlying structure of mental disorders: cross-diagnostic differences and similarities from a network perspective using both a top-down and a bottom-up approach by Wigman, J T W, van Os, J, Borsboom, D, Wardenaar, K J, Epskamp, S, Klippel, A, Viechtbauer, W, Myin-Germeys, I, Wichers, M

“…It has been suggested that the structure of psychopathology is best described as a complex network of components that interact in dynamic ways. The goal of the…”
Get more information

A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium by SANTEL, A, ALEKU, M, GIESE, K, KLIPPEL, A, KAUFMANN, J, KEIL, O, ENDRUSCHAT, J, ESCHE, V, FISCH, G, DAMES, S, LÖFFLER, K, FECHTNER, M, ARNOLD, W

“…For the application of RNA interference (RNAi) in vivo the functional delivery of short interfering RNAs (siRNAs) is still the major obstacle. Therefore,…”
Get full text

Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4 by Bjorklund, C C, Lu, L, Kang, J, Hagner, P R, Havens, C G, Amatangelo, M, Wang, M, Ren, Y, Couto, S, Breider, M, Ning, Y, Gandhi, A K, Daniel, T O, Chopra, R, Klippel, A, Thakurta, A G

“…Recent discoveries suggest that the critical events leading to the anti-proliferative activity of the IMiD immunomodulatory agents lenalidomide and…”
Get full text

Analysing spatio-temporal autocorrelation with LISTA-Viz by Hardisty, F., Klippel, A.

“…Many interesting analysis problems (e.g. disease surveillance) would become more tractable if their spatio-temporal structure was better understood…”
Get full text

RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy by SANTEL, A, ALEKU, M, DAMES, S, ARNOLD, W, GIESE, K, KLIPPEL, A, KAUFMANN, J, KEIL, O, ENDRUSCHAT, J, ESCHE, V., DURIEUX, B, LÖFFLER, K, FECHTNER, M, RÖHL, T, FISCH, G

“…RNA interference (RNAi) entails the potential for novel therapeutic strategies through the silencing of disease-causing genes in vivo. However, recent studies…”
Get full text

EMBODIED DIGITAL TWINS FOR ENVIRONMENTAL APPLICATIONS by Klippel, A., Sajjadi, P., Zhao, J., Wallgrün, J. O., Huang, J., Bagher, M. M.

“…The synergies of advances in environmental sensing and modeling and the mainstreaming of immersive technologies lay the foundation for a theoretical grounding…”
Get full text

p120 catenin is a key effector of a Ras-PKC epsilon oncogenic signaling axis by Dann, S G, Golas, J, Miranda, M, Shi, C, Wu, J, Jin, G, Rosfjord, E, Upeslacis, E, Klippel, A

“…Within the family of protein kinase C (PKC) molecules, the novel isoform PRKCE (PKC epsilon ) acts as a bona fide oncogene in in vitro and in vivo models of…”
Get full text

Initial results from a phase I/IIa trial evaluating BMS-986158, an inhibitor of the bromodomain and extra-terminal (BET) proteins, in patients (pts) with advanced cancer by Hilton, J, Cristea, M C, Voskoboynik, M, Postel-Vinay, S, Edenfield, W, Gavai, A, Wee, S, Srivastava, N, Klippel, A, Jackson, D, Apfel, A, Chasalow, S D, Williams, D, Donovan, M, Fischer, B, Khaldoyanidi, S, Diamond, J R

Get full text

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt by Kulik, George, Klippel, Anke, Weber, Michael J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

A FRAMEWORK FOR LOW-COST MULTI-PLATFORM VR AND AR SITE EXPERIENCES by Wallgrün, J. O., Huang, J., Zhao, J., Masrur, A., Oprean, D., Klippel, A.

“…Low-cost consumer-level immersive solutions have the potential to revolutionize education and research in many fields by providing virtual experiences of sites…”
Get full text

PITFALLS AND POTENTIALS OF CROWD SCIENCE: A META-ANALYSIS OF CONTEXTUAL INFLUENCES by Klippel, A., Sparks, K., Wallgrün, J. O.

“…Crowd science is becoming an integral part of research in many disciplines. The research discussed in this paper lies at the intersection of spatial and…”
Get full text

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain by Klippel, Anke, Kavanaugh, W. Michael, Pot, David, Williams, Lewis T.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways by Klippel, Anke, Reinhard, Christoph, Kavanaugh, W. Michael, Apell, Gerald, Escobedo, Maria-Amelia, Williams, Lewis T.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Rate of CRL4CRBN substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4 by Bjorklund, C C, Lu, L, Kang, J, Hagner, P R, Havens, C G, Amatangelo, M, Wang, M, Ren, Y, Couto, S, Breider, M, Ning, Y, Gandhi, A K, Daniel, T O, Chopra, R, Klippel, A, Thakurta, A G

“…Recent discoveries suggest that the critical events leading to the anti-proliferative activity of the IMiD immunomodulatory agents lenalidomide and…”
Get full text

Evidence for Phosphatidylinositol 3-Kinase as a Regulator of Endocytosis Via Activation of Rab5 by Li, Guangpu, D'Souza-Schorey, Crislyn, Barbieri, M. Alejandro, Roberts, Richard L., Klippel, Anke, Williams, Lewis T., Stahl, Philip D.

“…Phosphatidylinositol (PI) 3-kinases have been implicated in several aspects of intracellular membrane trafficking, although a detailed mechanism is yet to be…”
Get full text

Phosphatidylinositol 3-Kinase Signals Activation of p70 S6 Kinase in situ through Site-Specific p70 Phosphorylation by Weng, Qing-Ping, Andrabi, Khurshid, Klippel, Anke, Kozlowski, Mark T., Williams, Lewis T., Avruch, Joseph

“…The p70 S6 kinase is activated by insulin and mitogens through multisite phosphorylation of the enzyme. One set of activating phosphorylations occurs in a…”
Get full text

Management Innovation, a way for mining companies to survive in a globalized world by Klippel, A.F., Petter, C.O., Antunes, J.A.V.

“…Among alternatives that ensure the survival of companies, innovation is one of the most relevant. Innovation may include dimensions such as: (i) the raw…”
Get full text

Identification of novel effectors of invasive cell growth downstream of phosphoinositide 3-kinase by Kaufmann, J, Pronk, G, Giese, K, Klippel, A

“…Conventional approaches to identifying cancer targets are complicated by the chromosomal instability of tumour cells, and typically result in a large number of…”
Get more information

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity by KLIPPEL, A, ESCOBEDO, J. A, HIRANO, M, WILLIAMS, L. T

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and phosphatidylinositol 3-kinase by Deuter-Reinhard, Maja, Apell, Gerald, Pot, David, Klippel, Anke, Williams, Lewis T., Kavanaugh, W. Michael

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text