Search Results - "Klinz, SG"

Abstract OT3-02-14: A phase 1 study in patients with metastatic breast cancer to evaluate the feasibility of magnetic resonance imaging with ferrumoxytol as a potential biomarker for response to treatment with nanoliposomal irinotecan (nal-IRI, MM-398) by Sachdev, JC, Ramanathan, RK, Raghunand, N, Anders, C, Munster, P, Minton, S, Northfelt, D, Blanchette, S, Campbell, K, Lee, H, Klinz, SG, Hendriks, BS, Moyo, V, Fitzgerald, JB, Korn, RL

“…Background: Nal-IRI (MM-398, nanoliposomal irinotecan) is designed for extended circulation relative to free irinotecan and to exploit leaky tumor vasculature…”
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Multiscale Kinetic Modeling of Liposomal Doxorubicin Delivery Quantifies the Role of Tumor and Drug‐Specific Parameters in Local Delivery to Tumors by Hendriks, BS, Reynolds, JG, Klinz, SG, Geretti, E, Lee, H, Leonard, SC, Gaddy, DF, Espelin, CW, Nielsen, UB, Wickham, TJ

“…Nanoparticle encapsulation has been used as a means to manipulate the pharmacokinetic (PK) and safety profile of drugs in oncology. Using pegylated liposomal…”
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An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity by Goi, Takanori, Shipitsin, Michail, Lu, Zhimin, Foster, David A., Klinz, Stephan G., Feig, Larry A.

“…c‐Src is a membrane‐associated tyrosine kinase that can be activated by many types of extracellular signals, and can regulate the function of a variety of…”
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Neural cell adhesion molecules modulate tyrosine phosphorylation of tubulin in nerve growth cone membranes by Atashi, J R, Klinz, S G, Ingraham, C A, Matten, W T, Schachner, M, Maness, P F

“…Triggering neural cell adhesion molecules of the immunoglobulin superfamily with specific ligands or antibodies inhibited the phosphorylation of tryosyl…”
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L1 and N-CAM antibodies trigger protein phosphatase activity in growth cone-enriched membranes by Klinz, S G, Schachner, M, Maness, P F

“…Triggering of the cell adhesion molecules L1 or N-CAM in a nerve growth cone membrane fraction from fetal rat brain with purified L1 or N-CAM or specific…”
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Selective neural cell adhesion molecule signaling by Src family tyrosine kinases and tyrosine phosphatases by Maness, P F, Beggs, H E, Klinz, S G, Morse, W R

“…Nerve growth cone guidance is a highly complex feat, involving coordination of cell adhesion molecules, trophic factor gradients, and extracellular matrix…”
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Protein tyrosine phosphatases expressed in developing brain and retinal Müller glia by SHOCK, L. P, BARE, D. J, KLINZ, S. G, MANESS, P. F

“…Regulation of protein function through tyrosine phosphorylation is critical to many developmental processes involving cell-cell communication. A number of…”
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