Search Results - "Klinman, D M"

Human Peripheral Blood Cells Differentially Recognize and Respond to Two Distinct CpG Motifs by Verthelyi, Daniela, Ishii, Ken J, Gursel, Mayda, Takeshita, Fumihiko, Klinman, Dennis M

“…Oligodeoxynucleotides (ODN) that contain unmethylated CpG dinucleotides trigger a strong innate immune response in vertebrates. CpG ODN show promise as vaccine…”
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Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells by Takeshita, Fumihiko, Leifer, Cynthia A, Gursel, Ihsan, Ishii, Ken J, Takeshita, Saoko, Gursel, Mayda, Klinman, Dennis M

“…Unmethylated CpG motifs present in bacterial DNA stimulate a rapid and robust innate immune response. Human cell lines and PBMC that recognize CpG DNA express…”
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Contribution of CpG motifs to the immunogenicity of DNA vaccines by Klinman, DM, Yamshchikov, G, Ishigatsubo, Y

“…We previously showed that bacterial DNA contains immunostimulatory motifs consisting of unmethylated CpG dinucleotides flanked by two 5' purines and two 3'…”
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Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV by XIN, K.-Q, JOUNAI, N, OKUDA, K, HONDA, M, KLINMAN, D. M, OKUDA, K, SOMEYA, K, HONMA, K, MIZUGUCHI, H, NAGANAWA, S, KITAMURA, K, HAYAKAWA, T, SAHA, S, TAKESHITA, F

“…Immunization involving a DNA vaccine prime followed by an adenovirus type 5 (Ad5) boost elicited a protective immune response against SHIV challenge in…”
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Sex hormone levels correlate with the activity of cytokine‐secreting cells in vivo by Verthelyi, D., Klinman, D. M.

“…Summary This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA‐S) and the number of human…”
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suppressive oligodeoxynucleotide inhibits ocular inflammation by Fujimoto, C, Klinman, D.M, Shi, G, Yin, H, Vistica, B.P, Lovaas, J.D, Wawrousek, E.F, Igarashi, T, Chan, C.-C, Gery, I

“…Synthetic oligodeoxynucleotides (ODN) expressing 'suppressive' TTAGGG motifs down-regulate a variety of proinflammatory and T helper type 1 (Th1)-mediated…”
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Sterically Stabilized Cationic Liposomes Improve the Uptake and Immunostimulatory Activity of CpG Oligonucleotides by Gursel, Ihsan, Gursel, Mayda, Ishii, Ken J, Klinman, Dennis M

“…Immunostimulatory CpG oligonucleotides (ODN) show promise as immune adjuvants, anti-allergens, and immunoprotective agents. Increasing the bioavailability and…”
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CpG motifs as immune adjuvants by Klinman, Dennis M., Barnhart, Kerry M., Conover, Jacqueline

“…Bacterial DNA contains immunostimulatory motifs that trigger an innate immune response characterized by the production of predominantly Th1-type cytokines…”
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Genomic DNA Released by Dying Cells Induces the Maturation of APCs by Ishii, Ken J, Suzuki, Koichi, Coban, Cevayir, Takeshita, Fumihiko, Itoh, Yasushi, Matoba, Hana, Kohn, Leonard D, Klinman, Dennis M

“…Mature APCs play a key role in the induction of Ag-specific immunity. This work examines whether genomic DNA released by dying cells provides a stimulus for…”
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Repeated Administration of Synthetic Oligodeoxynucleotides Expressing CpG Motifs Provides Long-Term Protection against Bacterial Infection by KLINMAN, D. M, CONOVER, J, COBAN, C

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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CpG motifs in bacterial DNA trigger direct B-cell activation by Krieg, Arthur M, Yi, Ae-Kyung, Matson, Sara, Waldschmidt, Thomas J, Bishop, Gail A, Teasdale, Rebecca, Koretzky, Gary A, Klinman, Dennis M

“…Unmethylated CpG dinucleotides are more frequent in the genomes of bacteria and viruses than of vertebrates. We report here that bacterial DNA and synthetic…”
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Hierarchical recognition of CpG motifs expressed by immunostimulatory oligodeoxynucleotides by KLINMAN, D. M., CURRIE, D.

“…SUMMARY Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs trigger human PBMC to proliferate and secrete Ig, cytokines and chemokines…”
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Immunotherapeutic uses of CpG oligodeoxynucleotides by Klinman, Dennis M

“…Synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory CpG motifs trigger an immunomodulatory cascade that involves B and T cells, natural…”
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Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway by Yi, AK, Klinman, DM, Martin, TL, Matson, S, Krieg, AM

“…Unmethylated CpG dinucleotides (CpG motif) in bacterial DNA or synthetic oligodeoxynucleotides (CpG DNA) rapidly activate murine B cells to secrete IL-6 and…”
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Response of peripheral blood mononuclear cells from lupus patients to stimulation by CpG oligodeoxynucleotides by Zeuner, R. A., Klinman, D. M., Illei, G., Yarboro, C., Ishii, K. J., Gursel, M., Verthelyi, D.

“…Objectives. Increased levels of hypomethylated CpG‐containing DNA in sera from patients with systemic lupus erythematosus (SLE) may contribute to the…”
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CpG Oligodeoxynucleotides and Interleukin-12 Improve the Efficacy of Mycobacterium bovis BCG Vaccination in Mice Challenged with M. tuberculosis by FREIDAG, B. L, MELTON, G. B, COLLINS, F, KLINMAN, D. M, CHEEVER, A, STOBIE, L, SUEN, W, SEDER, R. A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Polyclonal B cell activation in lupus-prone mice precedes and predicts the development of autoimmune disease by KLINMAN, D. M

“…Polyclonal B cell activation is an early feature of autoimmune disease in humans and mice with systemic lupus erythematosus. The contribution of polyclonal…”
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Efficacy, immunogenicity, safety, and use of live attenuated chickenpox vaccine by Krause, Philip R., Klinman, Dennis M.

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Protection against anthrax toxin by vaccination with a DNA plasmid encoding anthrax protective antigen by Gu, Mi-Li, Leppla, Stephen H, Klinman, Dennis M

“…A DNA vaccine encoding the immunogenic and biologically active portion of anthrax protective antigen (PA) was constructed. Spleen cells from BALB/c mice…”
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Disassociation of sex hormone levels and cytokine production in SLE patients by Verthelyi, D, Petri, M, Ylamus, M, Klinman, D M

“…This study examines whether changes in the cytokine milieu of patients with systemic lupus erythematosus (SLE) are associated with abnormal levels of sex…”
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