Search Results - "Klinker, Kenneth"

Clinical and Microbiologic Outcomes in Patients with Monomicrobial Stenotrophomonas maltophilia Infections by Nys, Cara, Cherabuddi, Kartik, Venugopalan, Veena, Klinker, Kenneth P

“…is an opportunistic pathogen observed in nosocomial infections. Due to biofilm production and resistance to numerous antimicrobials, eradication is difficult…”
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Beyond Vancomycin: The Tail of the Lipoglycopeptides by Klinker, Kenneth P., PharmD, Borgert, Samuel J., PharmD

“…Abstract Purpose The purpose of this comparative review is to provide clinical information on the semisynthetic lipoglycopeptides (telavancin, oritavancin, and…”
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Association Between Social Vulnerability and Streptococcus pneumoniae Antimicrobial Resistance in US Adults by Mohanty, Salini, Ye, Gang, Sheets, Charles, Cossrow, Nicole, Yu, Kalvin C, White, Meghan, Klinker, Kenneth P, Gupta, Vikas

“…Growing evidence indicates antimicrobial resistance disproportionately affects individuals living in socially vulnerable areas. This study evaluated the…”
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Towards precision medicine: Therapeutic drug monitoring–guided dosing of vancomycin and β-lactam antibiotics to maximize effectiveness and minimize toxicity by Cusumano, Jaclyn A, Klinker, Kenneth P, Huttner, Angela, Luther, Megan K, Roberts, Jason A, LaPlante, Kerry L

“…Abstract Purpose The goal of this review is to explore the role of antimicrobial therapeutic drug monitoring (TDM), especially in critically ill, obese, and…”
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Optimization of Voriconazole Therapy for the Treatment of Invasive Fungal Infections in Adults by Mangal, Naveen, Hamadeh, Issam S., Arwood, Meghan J., Cavallari, Larisa H., Samant, Tanay S., Klinker, Kenneth P., Bulitta, Jurgen, Schmidt, Stephan

“…Therapeutic concentrations of voriconazole in invasive fungal infections (IFIs) are ensured using a drug monitoring approach, which relies on attainment of…”
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Clinical and economic impact of antimicrobial stewardship interventions with the FilmArray blood culture identification panel by Pardo, Joe, Klinker, Kenneth P, Borgert, Samuel J, Butler, Brittany M, Giglio, Patricia G, Rand, Kenneth H

“…Abstract The purpose of this study was to evaluate the impact of the FilmArray Blood Culture Identification (BCID) Panel on the management of patients with…”
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Ampicillin for the treatment of complicated urinary tract infections caused by vancomycin–resistant Enterococcus spp (VRE): a single-center university hospital experience by Shah, Kairav J., Cherabuddi, Kartikeya, Shultz, Joseph, Borgert, Samuel, Ramphal, Reuben, Klinker, Kenneth P.

“…•Analysis of ampicillin for treatment of vancomycin-resistant Enterococcus spp (VRE) urinary tract infections.•Largest data set that evaluates this in-vitro…”
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Assessing antimicrobial stewardship initiatives: Clinical evaluation of cefepime or piperacillin/tazobactam in patients with bloodstream infections secondary to AmpC-producing organisms by McKamey, Lacie, Venugopalan, Veena, Cherabuddi, Kartikeya, Borgert, Samuel, Voils, Stacy, Shah, Kairav, Klinker, Kenneth P.

“…•Alternatives to carbapenems are of interest for treating AmpC-producing organisms.•Cefepime or piperacillin/tazobactam displayed high clinical cure in…”
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Association of SARS-CoV-2 status and antibiotic-resistant bacteria with inadequate empiric therapy in hospitalized patients: a US multicenter cohort evaluation (July 2019 - October 2021) by Bauer, Karri A, Puzniak, Laura A, Yu, Kalvin C, Klinker, Kenneth P, Watts, Janet A, Moise, Pamela A, Finelli, Lyn, Gupta, Vikas

“…Antibiotic usage and antibiotic resistance (ABR) patterns changed during the COVID-19 pandemic. Inadequate empiric antibiotic therapy (IET) is a significant…”
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Multicenter Observational Study of Ceftaroline Fosamil for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections by Zasowski, Evan J, Trinh, Trang D, Claeys, Kimberly C, Casapao, Anthony M, Sabagha, Noor, Lagnf, Abdalhamid M, Klinker, Kenneth P, Davis, Susan L, Rybak, Michael J

“…Novel therapies for methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) are needed in the setting of reduced antibiotic…”
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Acute kidney injury risk associated with piperacillin/tazobactam compared with cefepime during vancomycin therapy in hospitalised patients: a cohort study stratified by baseline kidney function by Jeon, Nakyung, Staley, Ben, Klinker, Kenneth P, Hincapie Castillo, Juan, Winterstein, Almut G

“…Highlights • Risk of AKI with vancomycin + piperacillin/tazobactam (VPT) versus vancomycin + cefepime (VC) was compared. • Elevated risk of AKI in hospitalised…”
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SCAN: A novel approach for vancomycin time-out by Manigaba, Kayihura, Borgert, Samuel J, Klinker, Kenneth P, Cherabuddi, Kartikeya, Venugopalan, Veena

“…To the Editor—Approximately 30%–50% of antimicrobials prescribed in hospitals are either inappropriate or unnecessary.1 The Joint Commission (TJC), Centers for…”
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Impact of the CYP2C19 genotype on voriconazole exposure in adults with invasive fungal infections by Hamadeh, Issam S, Klinker, Kenneth P, Borgert, Samuel J, Richards, Ashley I, Li, Wenhui, Mangal, Naveen, Hiemenz, John W, Schmidt, Stephan, Langaee, Taimour Y, Peloquin, Charles A, Johnson, Julie A, Cavallari, Larisa H

“…OBJECTIVESVoriconazole, a first-line agent for the treatment of invasive fungal infections (IFIs), is metabolized by CYP2C19. A significant proportion of…”
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Large Retrospective Evaluation of the Effectiveness and Safety of Ceftaroline Fosamil Therapy by CASAPAO, Anthony M, DAVIS, Susan L, RYBAK, Michael J, BARR, Viktorija O, KLINKER, Kenneth P, GOFF, Debra A, BARBER, Katie E, KAYE, Keith S, MYNATT, Ryan P, MOLLOY, Leah M, POGUE, Jason M

“…Ceftaroline has been approved for acute bacterial skin infections and community-acquired bacterial pneumonia. Limited clinical experience exists for use…”
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Survival in Patients with Candida glabrata Bloodstream Infection Is Associated with Fluconazole Dose by Eschenauer, Gregory A, Carver, Peggy L, Patel, Twisha S, Lin, Shu-Wen, Klinker, Kenneth P, Pai, Manjunath P, Lam, Simon W

“…Robust pharmacodynamic indices that align fluconazole dose or exposure with outcomes in invasive candidiasis due to remain elusive. The purpose of this…”
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Time to Positivity of Blood Cultures Supports Antibiotic De-escalation at 48 Hours by Pardo, Joe, Klinker, Kenneth P., Borgert, Samuel J., Trikha, Gaurav, Rand, Kenneth H., Ramphal, Reuben

“…Background: Appropriate de-escalation of empirical antimicrobial therapy is a fundamental component of antimicrobial stewardship. Concern for the late…”
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Antimicrobial Stewardship in the Emergency Department by Trinh, Trang D., Klinker, Kenneth P.

“…The literature contains robust evidence on the positive impact of antimicrobial stewardship programs (ASP) in the inpatient setting. With national policies…”
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Preventing the Post-Antibiotic Era by Training Future Pharmacists as Antimicrobial Stewards by Gallagher, Jason C., Justo, Julie Ann, Chahine, Elias B., Bookstaver, P. Brandon, Scheetz, Marc, Suda, Katie J., Fehrenbacher, Lynne, Klinker, Kenneth P., MacDougall, Conan

“…Antimicrobials enable modern medicine, but their efficacy is a limited resource. In the past 20 years, antimicrobial development has slowed dramatically while…”
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Real-World Experience with Echinocandin MICs against Candida Species in a Multicenter Study of Hospitals That Routinely Perform Susceptibility Testing of Bloodstream Isolates by ESCHENAUER, Gregory A, HONG NGUYEN, M, CHEN, Sharon, LAM, Simon W, POTOSKI, Brian A, CLARKE, Lloyd G, SHIELDS, Ryan K, CLANCY, Cornelius J, SHOHAM, Shmuel, VAZQUEZ, Jose A, MORRIS, Arthur J, PASCULLE, William A, KUBIN, Christine J, KLINKER, Kenneth P, CARVER, Peggy L, HANSON, Kimberly E

“…Reference broth microdilution methods of Candida echinocandin susceptibility testing are limited by interlaboratory variability in caspofungin MICs. Recently…”
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Antimicrobial stewardship and antibiograms: importance of moving beyond traditional antibiograms by Klinker, Kenneth P., Hidayat, Levita K., DeRyke, C. Andrew, DePestel, Daryl D., Motyl, Mary, Bauer, Karri A.

“…The rapid evolution of resistance, particularly among Gram-negative bacteria, requires appropriate identification of patients at risk followed by…”
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