Search Results - "Klinken, Jan Bert"

Detrimental effects of constant light exposure and high‐fat diet on circadian energy metabolism and insulin sensitivity by Coomans, Claudia P., Berg, Sjoerd A. A., Houben, Thijs, Klinken, Jan‐Bert, Berg, Rosa, Pronk, Amanda C. M., Havekes, Louis M., Romijn, Johannes A., Dijk, Ko Willems, Biermasz, Nienke R., Meijer, Johanna H.

“…Circadian rhythm disturbances are observed in, e.g., aging and neurodegenerative diseases and are associated with an increased incidence of obesity and…”
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The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men by Nahon, Kimberly J., Janssen, Laura G. M., Sardjoe Mishre, Aashley S. D., Bilsen, Manu P., Eijk, Jari A., Botani, Kani, Overduin, Lisanne A., Ruiz, Jonatan R., Burakiewicz, Jedrzej, Dzyubachyk, Oleh, Webb, Andrew G., Kan, Hermien E., Berbée, Jimmy F. P., Klinken, Jan‐Bert, Dijk, Ko Willems, Weeghel, Michel, Vaz, Frédéric M., Coskun, Tamer, Jazet, Ingrid M., Kooijman, Sander, Martinez‐Tellez, Borja, Boon, Mariëtte R., Rensen, Patrick C. N.

“…Aim To compare the effects of cold exposure and the β3‐adrenergic receptor agonist mirabegron on plasma lipids, energy expenditure and brown adipose tissue…”
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Alterations in ether lipid metabolism and the consequences for the mouse lipidome by Lackner, Katharina, Sailer, Sabrina, van Klinken, Jan-Bert, Wever, Eric, Pras-Raves, Mia L., Dane, Adrie D., Honsho, Masanori, Abe, Yuichi, Keller, Markus A., Golderer, Georg, Werner-Felmayer, Gabriele, Fujiki, Yukio, Vaz, Frédéric M., Werner, Ernst R., Watschinger, Katrin

“…Alkylglycerol monooxygenase (AGMO) and plasmanylethanolamine desaturase (PEDS1) are enzymes involved in ether lipid metabolism. While AGMO degrades plasmanyl…”
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Apolipoprotein A5 deficiency aggravates high‐fat diet‐induced obesity due to impaired central regulation of food intake by Berg, Sjoerd A. A., Heemskerk, Mattijs M., Geerling, Janine J., Klinken, Jan‐Bert, Schaap, Frank G., Bijland, Silvia, Berbée, Jimmy F. P., Harmelen, Vanessa J. A., Pronk, Amanda C. M, Schreurs, Marijke, Havekes, Louis M., Rensen, Patrick C. N, Dijk, Ko Willems

“…Mutations in apolipoprotein A5 (APOA5) have been associated with hypertriglyceridemia in humans and mice. This has been attributed to a stimulating role for…”
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Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease by Lee, Richard G, Balasubramaniam, Shanti, Stentenbach, Maike, Kralj, Tom, McCubbin, Tim, Padman, Benjamin, Smith, Janine, Riley, Lisa G, Priyadarshi, Archana, Peng, Liuyu, Nuske, Madison R, Webster, Richard, Peacock, Ken, Roberts, Philip, Stark, Zornitza, Lemire, Gabrielle, Ito, Yoko A, Boycott, Kym M, Geraghty, Michael T, van Klinken, Jan Bert, Ferdinandusse, Sacha, Zhou, Ying, Walsh, Rebecca, Marcellin, Esteban, Thorburn, David R, Rosciolli, Tony, Fletcher, Janice, Rackham, Oliver, Vaz, Frédéric M, Reid, Gavin E, Filipovska, Aleksandra

“…Mitochondrial diseases are a group of inherited diseases with highly varied and complex clinical presentations. Here, we report four individuals, including two…”
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A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes by Liu, Jun, van Klinken, Jan Bert, Semiz, Sabina, van Dijk, Ko Willems, Verhoeven, Aswin, Hankemeier, Thomas, Harms, Amy C, Sijbrands, Eric, Sheehan, Nuala A, van Duijn, Cornelia M, Demirkan, Ayşe

“…Mendelian randomization (MR) provides us the opportunity to investigate the causal paths of metabolites in type 2 diabetes and glucose homeostasis. We…”
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Tracer‐based lipidomics enables the discovery of disease‐specific candidate biomarkers in mitochondrial β‐oxidation disorders by Schwantje, Marit, Mosegaard, Signe, Knottnerus, Suzan J. G., Klinken, Jan Bert, Wanders, Ronald J., Lenthe, Henk, Hermans, Jill, IJlst, Lodewijk, Denis, Simone W., Jaspers, Yorrick R. J., Fuchs, Sabine A., Houtkooper, Riekelt H., Ferdinandusse, Sacha, Vaz, Frédéric M.

“…Carnitine derivatives of disease‐specific acyl‐CoAs are the diagnostic hallmark for long‐chain fatty acid β‐oxidation disorders (lcFAOD), including carnitine…”
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A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals by Deelen, Joris, Kettunen, Johannes, Fischer, Krista, van der Spek, Ashley, Trompet, Stella, Kastenmüller, Gabi, Boyd, Andy, Zierer, Jonas, van den Akker, Erik B., Ala-Korpela, Mika, Amin, Najaf, Demirkan, Ayse, Ghanbari, Mohsen, van Heemst, Diana, Ikram, M. Arfan, van Klinken, Jan Bert, Mooijaart, Simon P., Peters, Annette, Salomaa, Veikko, Sattar, Naveed, Spector, Tim D., Tiemeier, Henning, Verhoeven, Aswin, Waldenberger, Melanie, Würtz, Peter, Davey Smith, George, Metspalu, Andres, Perola, Markus, Menni, Cristina, Geleijnse, Johanna M., Drenos, Fotios, Beekman, Marian, Jukema, J. Wouter, van Duijn, Cornelia M., Slagboom, P. Eline

“…Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics…”
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Hepatic triglyceride content is intricately associated with numerous metabolites and biochemical pathways by Faquih, Tariq O., Klinken, Jan Bert, Li‐Gao, Ruifang, Noordam, Raymond, Heemst, Diana, Boone, Sebastiaan, Sheridan, Patricia A., Michelotti, Gregory, Lamb, Hildo, Mutsert, Renée, Rosendaal, Frits R., Hylckama Vlieg, Astrid, Dijk, Ko Willems, Mook‐Kanamori, Dennis O.

“…Background and Aims Non‐alcoholic fatty liver disease (NAFLD) is characterized by the pathological accumulation of triglycerides in hepatocytes and is…”
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Adverse generational changes in obesity development converge at midlife without increased cardiometabolic risk by Ibi, Dorina, Rietman, M. Liset, Picavet, H. S. J., Klinken, Jan Bert, Dijk, Ko Willems, Dollé, Martijn E. T., Verschuren, W.M. Monique

“…Objective Obesity is becoming a global public health problem, but it is unclear how it impacts different generations over the life course. Here, a descriptive…”
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Reduced Feed Intake, Rather than Increased Energy Losses, Explains Variation in Growth Rates of Normal-Birth-Weight Piglets by van Erp, Rik J J, van Hees, Hubert M J, Zijlstra, Ruurd T, van Kempen, Theo A T G, van Klinken, Jan Bert, Gerrits, Walter J J

“…Substantial variation in growth rates exists in normal-birth-weight piglets, possibly due to differences in energy efficiency. Within this population, slow…”
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CD36 is important for adipocyte recruitment and affects lipolysis by Vroegrijk, Irene O.C.M., Klinken, Jan Bert, Diepen, Janna A., den Berg, Sjoerd A.A., Febbraio, Maria, Steinbusch, Laura K.M., Glatz, Jan F.C., Havekes, Louis M., Voshol, Peter J., Rensen, Patrick C.N., Dijk, Ko Willems, Harmelen, Vanessa

“…Objective: The scavenger receptor CD36 facilitates the cellular uptake of long‐chain fatty acids. As CD36‐deficiency attenuates the development of high fat…”
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Four-dimensional lipidomics profiling in X-linked adrenoleukodystrophy using trapped ion mobility mass spectrometry by Jaspers, Yorrick R.J., Meyer, Sven W., Pras-Raves, Mia L., Dijkstra, Inge M.E., Wever, Eric J.M., Dane, Adrie D., van Klinken, Jan-Bert, Salomons, Gajja S., Houtkooper, Riekelt H., Engelen, Marc, Kemp, Stephan, Van Weeghel, Michel, Vaz, Frédéric M.

“…Lipids play pivotal roles in an extensive range of metabolic and physiological processes. In recent years, the convergence of trapped ion mobility spectrometry…”
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Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation by Held, Ntsiki M., Kuipers, Eline N., van Weeghel, Michel, van Klinken, Jan Bert, Denis, Simone W., Lombès, Marc, Wanders, Ronald J., Vaz, Frédéric M., Rensen, Patrick C. N., Verhoeven, Arthur J., Boon, Mariëtte R., Houtkooper, Riekelt H.

“…Activation of brown adipose tissue (BAT) contributes to total body energy expenditure through energy dissipation as heat. Activated BAT increases the clearance…”
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Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B by Heemskerk, Mattijs M, van den Berg, Sjoerd A A, Pronk, Amanda C M, van Klinken, Jan-Bert, Boon, Mariëtte R, Havekes, Louis M, Rensen, Patrick C N, van Dijk, Ko Willems, van Harmelen, Vanessa

“…The lipid-lowering effect of niacin has been attributed to the inhibition of cAMP production in adipocytes, thereby inhibiting intracellular lipolysis and…”
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Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses by Demirkan, Ayşe, Henneman, Peter, Verhoeven, Aswin, Dharuri, Harish, Amin, Najaf, van Klinken, Jan Bert, Karssen, Lennart C, de Vries, Boukje, Meissner, Axel, Göraler, Sibel, van den Maagdenberg, Arn M J M, Deelder, André M, C 't Hoen, Peter A, van Duijn, Cornelia M, van Dijk, Ko Willems

“…Metabolite quantitative traits carry great promise for epidemiological studies, and their genetic background has been addressed using Genome-Wide Association…”
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Estimation of activity related energy expenditure and resting metabolic rate in freely moving mice from indirect calorimetry data by Van Klinken, Jan Bert, van den Berg, Sjoerd A A, Havekes, Louis M, Willems Van Dijk, Ko

“…Physical activity (PA) is a main determinant of total energy expenditure (TEE) and has been suggested to play a key role in body weight regulation. However,…”
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Angiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue by van Eenige, Robin, In het Panhuis, Wietse, Schönke, Milena, Jouffe, Céline, Devilee, Thomas H., Siebeler, Ricky, Streefland, Trea C.M., Sips, Hetty C.M., Pronk, Amanda C.M., Vorderman, Ruben H.P., Mei, Hailiang, van Klinken, Jan Bert, van Weeghel, Michel, Uhlenhaut, Nina H., Kersten, Sander, Rensen, Patrick C.N., Kooijman, Sander

“…Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking…”
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Western diet triggers cardiac dysfunction in heterozygous Mybpc3-targeted knock-in mice: A two-hit model of hypertrophic cardiomyopathy by Nollet, Edgar E., Algül, Sila, Goebel, Max, Schlossarek, Saskia, van der Wel, Nicole N., Jans, Judith J.M., van de Wiel, Mark A., Knol, Jaco C., Pham, Thang V., Piersma, Sander R., de Goeij-de Haas, Richard, Hermans, Jill, van Klinken, Jan Bert, van Weeghel, Michel, Houtkooper, Riekelt H., Carrier, Lucie, Jimenez, Connie R., Kuster, Diederik W.D., van der Velden, Jolanda

“…Phenotypic expression of hypertrophic cardiomyopathy (HCM) and disease course are associated with unfavorable metabolic health. We investigated if Western diet…”
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Prediction of murine liver kinetics from plasma lipoprotein distributions by Tiemann, Christian, Berg, Sjoerd, Klinken, Jan Bert, Dijk, Ko Willems, Jeneson, Jeroen, Hilbers, Peter, Riel, Natal

“…The role of liver in lipid metabolism has been studied extensively. However, due to the complexity of in vivo liver measurements, many experimental efforts…”
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