Search Results - "Klink, Magdalena"

The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer by Nowak, Marek, Klink, Magdalena

“…Tumor-associated macrophages (TAMs) constitute the main population of immune cells present in the ovarian tumor microenvironment. These cells are characterized…”
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The Potential Role of iNOS in Ovarian Cancer Progression and Chemoresistance by Kielbik, Michal, Szulc-Kielbik, Izabela, Klink, Magdalena

“…Inducible nitric oxide synthase (iNOS), the enzyme responsible for nitric oxide (NO) production, is not present in most cells under normal conditions. The…”
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Impact of Selected Signaling Proteins on SNAIL 1 and SNAIL 2 Expression in Ovarian Cancer Cell Lines in Relation to Cells' Cisplatin Resistance and EMT Markers Level by Kielbik, Michal, Szulc-Kielbik, Izabela, Klink, Magdalena

“…It has been increasingly recognized that SNAIL1 and SNAIL2, as major EMT-inducers, might also be involved in drug resistance of cancer cells. We sought to…”
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E-Cadherin Expression in Relation to Clinicopathological Parameters and Survival of Patients with Epithelial Ovarian Cancer by Kielbik, Michal, Szulc-Kielbik, Izabela, Klink, Magdalena

“…It is generally accepted that loss/reduction of E-cadherin expression on tumor cells promotes their migration, invasiveness, and metastasis. It is also an…”
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Calreticulin-Multifunctional Chaperone in Immunogenic Cell Death: Potential Significance as a Prognostic Biomarker in Ovarian Cancer Patients by Kielbik, Michal, Szulc-Kielbik, Izabela, Klink, Magdalena

“…Immunogenic cell death (ICD) is a type of death, which has the hallmarks of necroptosis and apoptosis, and is best characterized in malignant diseases…”
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Cholesterol oxidase is indispensable in the pathogenesis of Mycobacterium tuberculosis by Klink, Magdalena, Brzezinska, Marta, Szulc, Izabela, Brzostek, Anna, Kielbik, Michal, Sulowska, Zofia, Dziadek, Jaroslaw

“…Despite considerable research effort, the molecular mechanisms of Mycobacterium tuberculosis (Mtb) virulence remain unclear. Cholesterol oxidase (ChoD), an…”
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Adenosine Analogues as Opposite Modulators of the Cisplatin Resistance of Ovarian Cancer Cells by Bednarska-Szczepaniak, Katarzyna, Krzyżanowski, Damian, Klink, Magdalena, Nowak, Marek

“…Adenosine released by cancer cells in high amounts in the tumour microenvironment is one of the main immunosuppressive agents responsible for the escape of…”
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Cytotoxic effects of halophilic archaea metabolites on ovarian cancer cell lines by Kowalewicz-Kulbat, Magdalena, Krawczyk, Krzysztof T, Szulc-Kielbik, Izabela, Rykowski, Sebastian, Denel-Bobrowska, Marta, Olejniczak, Agnieszka B, Locht, Camille, Klink, Magdalena

“…Abstract Background Ovarian cancer is one of the most frequent and deadly gynaecological cancers, often resistant to platinum-based chemotherapy, the current…”
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Either non-homologous ends joining or homologous recombination is required to repair double-strand breaks in the genome of macrophage-internalized Mycobacterium tuberculosis by Brzostek, Anna, Szulc, Izabela, Klink, Magdalena, Brzezinska, Marta, Sulowska, Zofia, Dziadek, Jaroslaw

“…The intracellular pathogen Mycobacterium tuberculosis (Mtb) is constantly exposed to a multitude of hostile conditions and is confronted by a variety of…”
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Chemokine expression in patients with ovarian cancer or benign ovarian tumors by Nowak, Marek, Janas, Łukasz, Soja, Malwina, Głowacka, Ewa, Szyłło, Krzysztof, Misiek, Marcin, Klink, Magdalena

“…Chemokines play a crucial role in tumor growth and progression according to proangiogenic and immunosuppressive action. The aim of this study was to…”
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Mycobacterium tuberculosis Requires Cholesterol Oxidase to Disrupt TLR2 Signalling in Human Macrophages by Dziadek, Jaroslaw, Brzostek, Anna, Przygodzka, Patrycja, Kielbik, Michal, Szulc-Kielbik, Izabela, Klink, Magdalena

“…This study tested the hypothesis that Mycobacterium tuberculosis (Mtb) uses a cholesterol oxidase enzyme (ChoD) to suppress a toll-like receptor type 2-…”
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Severe inhibition of lipooligosaccharide synthesis induces TLR2-dependent elimination of Mycobacterium marinum from THP1-derived macrophages by Szulc-Kielbik, Izabela, Pawelczyk, Jakub, Kielbik, Michal, Kremer, Laurent, Dziadek, Jaroslaw, Klink, Magdalena

“…Although mycobacterial glycolipids are among the first-line molecules involved in host-pathogen interactions, their contribution in virulence remains…”
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Seasonal changes in activities of human neutrophils in vitro by Klink, Magdalena, Bednarska, Katarzyna, Blus, Edyta, Kielbik, Michal, Sulowska, Zofia

“…Objective and design We present a retrospective analysis of previously collected blood samples to determine whether the immune response of neutrophils depends…”
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Nitric oxide donors reduce the invasion ability of ovarian cancer cells in vitro by Kielbik, Michal, Szulc, Izabela, Brzezinska, Marta, Bednarska, Katarzyna, Przygodzka, Patrycja, Sulowska, Zofia, Nowak, Marek, Klink, Magdalena

“…The most important factors involved in tumor metastasis and angiogenesis are metalloproteinases (MMPs), vascular endothelial growth factor, and multifunctional…”
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Cholesterol Oxidase Binds TLR2 and Modulates Functional Responses of Human Macrophages by Dziadek, Jaroslaw, Sulowska, Zofia, Kielbik, Michal, Bednarska, Katarzyna, Klink, Magdalena

“…Cholesterol oxidase (ChoD) is considered to be an important virulence factor for Mycobacterium tuberculosis (Mtb), but its influence on macrophage activity is…”
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Antitumoral Activity Of Nitric Oxide-Releasing Compounds by Klink, Magdalena, Kielbik, Michal, Kielbik, Izabela Szulc, Przygodzka, Patrycja, Sulowska, Zofia

“…Despite significant improvements in the conventional anti-ovarian cancer therapies, tumor cell resistance to various cytostatic drugs remains a relevant…”
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Effect of nitric oxide donors on NADPH oxidase signaling pathway in human neutrophils in vitro by Klink, Magdalena, Jastrzembska, Katarzyna, Bednarska, Katarzyna, Banasik, Małgorzata, Sulowska, Zofia

“…Abstract The production of reactive oxygen species (ROS) in activated neutrophils is catalyzed by NADPH oxidase, a multiproteins complex. Various protein…”
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Snail transcription factors – Characteristics, regulation and molecular targets relevant in vital cellular activities of ovarian cancer cells by Kielbik, Michal, Szulc-Kielbik, Izabela, Klink, Magdalena

“…Snail transcription factors play essential roles in embryonic development and participate in many physiological processes. However, these genes have been…”
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The implication of IL-6 in the invasiveness and chemoresistance of ovarian cancer cells. Systematic review of its potential role as a biomarker in ovarian cancer patients by Szulc-Kielbik, Izabela, Kielbik, Michal, Nowak, Marek, Klink, Magdalena

“…Interleukin 6 (IL-6) is a pleiotropic cytokine that is strongly implicated in the development and progression of ovarian cancer. The most recognized actions of…”
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Snail transcription factors as key regulators of chemoresistance, stemness and metastasis of ovarian cancer cells by Kielbik, Michal, Przygodzka, Patrycja, Szulc-Kielbik, Izabela, Klink, Magdalena

“…Ovarian cancer is one of the deadliest gynecological malignancies among women. The reason for this outcome is the frequent acquisition of cancer cell…”
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