Search Results - "Klinger, Alexandra"

The Molecular Basis for Species-specific Activation of Human TRPA1 Protein by Protons Involves Poorly Conserved Residues within Transmembrane Domains 5 and 6 by de la Roche, Jeanne, Eberhardt, Mirjam J., Klinger, Alexandra B., Stanslowsky, Nancy, Wegner, Florian, Koppert, Wolfgang, Reeh, Peter W., Lampert, Angelika, Fischer, Michael J.M., Leffler, Andreas

“…The surveillance of acid-base homeostasis is concerted by diverse mechanisms, including an activation of sensory afferents. Proton-evoked activation of rodent…”
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Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores by Sobolewski, Peter, Kandel, Judith, Klinger, Alexandra L, Eckmann, David M

“…Gas embolism is a serious complication of decompression events and clinical procedures, but the mechanism of resulting injury remains unclear. Previous work…”
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A Synchrotron-Based Hydroxyl Radical Footprinting Analysis of Amyloid Fibrils and Prefibrillar Intermediates with Residue-Specific Resolution by Klinger, Alexandra L, Kiselar, Janna, Ilchenko, Serguei, Komatsu, Hiroaki, Chance, Mark R, Axelsen, Paul H

“…Structural models of the fibrils formed by the 40-residue amyloid-β (Aβ40) peptide in Alzheimer’s disease typically consist of linear polypeptide segments,…”
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Inherited pain: sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivation by Eberhardt, Mirjam, Nakajima, Julika, Klinger, Alexandra B, Neacsu, Cristian, Hühne, Kathrin, O'Reilly, Andrias O, Kist, Andreas M, Lampe, Anne K, Fischer, Kerstin, Gibson, Jane, Nau, Carla, Winterpacht, Andreas, Lampert, Angelika

“…Inherited erythromelalgia (IEM) causes debilitating episodic neuropathic pain characterized by burning in the extremities. Inherited "paroxysmal extreme pain…”
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Sea-Anemone Toxin ATX-II Elicits A-Fiber-Dependent Pain and Enhances Resurgent and Persistent Sodium Currents in Large Sensory Neurons by Klinger, Alexandra B, Eberhardt, Mirjam, Link, Andrea S, Namer, Barbara, Kutsche, Lisa K, Schuy, E Theresa, Sittl, Ruth, Hoffmann, Tali, Alzheimer, Christian, Huth, Tobias, Carr, Richard W, Lampert, Angelika

“…Background: Gain-of-function mutations of the nociceptive voltage-gated sodium channel Nav1.7 lead to inherited pain syndromes, such as paroxysmal extreme pain…”
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Mutagenesis of the NaChBac sodium channel discloses a functional role for a conserved S6 asparagine by O’Reilly, Andrias O., Lattrell, Anja, Miles, Andrew J., Klinger, Alexandra B., Nau, Carla, Wallace, B. A., Lampert, Angelika

“…Asparagine is conserved in the S6 transmembrane segments of all voltage-gated sodium, calcium, and TRP channels identified to date. A broad spectrum of…”
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Pefluorocarbon inhibition of bubble induced Ca2+ transients in an in vitro model of vascular gas embolism by Klinger, Alexandra L, Kandel, Judith, Pichette, Benjamin, Eckmann, David M

“…Endothelial injury resulting from deleterious interaction of gas microbubbles occurs in many surgical procedures and other medical interventions. The symptoms…”
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Mechanotransductional basis of endothelial cell response to intravascular bubbles by Klinger, Alexandra L, Pichette, Benjamin, Sobolewski, Peter, Eckmann, David M

“…Vascular air embolism resulting from too rapid decompression is a well-known risk in deep-sea diving, aviation and space travel. It is also a common…”
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Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors by Eberhardt, Esther, Havlicek, Steven, Schmidt, Diana, Link, Andrea S., Neacsu, Cristian, Kohl, Zacharias, Hampl, Martin, Kist, Andreas M., Klinger, Alexandra, Nau, Carla, Schüttler, Jürgen, Alzheimer, Christian, Winkler, Jürgen, Namer, Barbara, Winner, Beate, Lampert, Angelika

“…Human pluripotent stem cells (hPSCs) offer the opportunity to generate neuronal cells, including nociceptors. Using a chemical-based approach, we generated…”
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Structural determination of estrogen-related receptor γ in the presence of phenol derivative compounds by Abad, Marta C., Askari, Hossein, O’Neill, John, Klinger, Alexandra L., Milligan, Cynthia, Lewandowski, Frank, Springer, Barry, Spurlino, John, Rentzeperis, Dionisios

“…We screened the ligand-binding domain of estrogen-related receptor (ERR) γ in ThermoFluor ®, in an effort to develop chemical tools and decipher the biology of…”
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Inhibition of Carbonic Anhydrase-II by Sulfamate and Sulfamide Groups:  An Investigation Involving Direct Thermodynamic Binding Measurements by Klinger, Alexandra L, McComsey, David F, Smith-Swintosky, Virginia, Shank, Richard P, Maryanoff, Bruce E

“…This paper examines the relative effectiveness of bioisosteric sulfamate and sulfamide derivatives for inhibition of human carbonic anhydrase-II (CA-II) by…”
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A MurF Inhibitor That Disrupts Cell Wall Biosynthesis in Escherichia coli by Baum, Ellen Z, Crespo-Carbone, Steven M, Klinger, Alexandra, Foleno, Barbara D, Turchi, Ignatius, Macielag, Mark, Bush, Karen

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Thermal stability landscape for Klenow DNA polymerase as a function of pH and salt concentration by Richard, Allison J., Liu, Chin-Chi, Klinger, Alexandra L., Todd, Matthew J., Mezzasalma, Tara M., LiCata, Vince J.

“…The thermal denaturation of Klenow DNA polymerase has been characterized over a wide variety of solution conditions to obtain a relative stability landscape…”
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Asymmetric Distribution of Cooperativity in the Binding Cascade of Normal Human Hemoglobin. 1. Cooperative and Noncooperative Oxygen Binding in Zn-Substituted Hemoglobin by Holt, Jo M, Klinger, Alexandra L, Yarian, Connie S, Keelara, Varsha, Ackers, Gary K

“…The complete binding cascade of human hemoglobin consists of eight partially ligated intermediates and 16 binding constants. Each intermediate binding constant…”
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Quantitative Hydroxyl Radical Footprinting Study Reveals Structural Details of the Disorder-to-Order Transition in Amyloid-Beta (1-42) Oligomerization by Kiselar, Janna, Nix, Andrew, Paravastu, Anant, Rosenberry, Terrone, Klinger, Alexandra

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Proton transfer from Asp-96 to the bacteriorhodopsin Schiff base is caused by a decrease of the pKa of Asp-96 which follows a protein backbone conformational change by Cao, Yi, Varo, Gyorgy, Klinger, Alexandra L, Czajkowsky, Daniel M, Braiman, Mark S, Needleman, Richard, Lanyi, Janos K

“…In the bacteriorhodopsin photocycle the transported proton crosses the major part of the hydrophobic barrier during the M to N reaction; in this step the…”
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Thermodynamic Studies on the Equilibrium Properties of a Series of Recombinant βW37 Hemoglobin Mutants by Kiger, Laurent, Klinger, Alexandra L, Kwiatkowski, Laura D, De Young, Alice, Doyle, Michael L, Holt, Jo M, Noble, Robert W, Ackers, Gary K

“…In human hemoglobin (Hb) the β37 tryptophan residue (βW37), located at the hinge region of the α1β2 interface, forms many contacts with α subunit residues of…”
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Quantitative Sequence Specific Protein Footprinting Reveals Structural Details of Amyloid‐β (1‐42) Peptide Oligomerization by Klinger, Alexandra L, Kiselar, Janna, Nix, Andrew J, Paravastu, Anant, Rosenberry, Terrone L

“…Abstract only Synchrotron based hydroxyl radical footprinting (HRF) was employed to study the formation of Aβ 42 oligomers, believed to be the neurotoxic…”
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Sequence Specific Radiolytic Footprinting Study of Monomer, Oligomeric and Fibrillar Amyloid Beta (1-42) by Klinger, Alexandra L., Kiselar, Janna, Paravastu, Anant, Rosenberry, Terrone

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Sequence Specific Quantitative Hydroxyl Radical Footprinting Reveals Structural Details of Amyloid-ß (1-42) Peptide Oligomerization by Kiselar, Janna, Nix, Andrew, Paravastu, Anant, Terrone, Rosenberry L., Klinger, Alexandra L.

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