Search Results - "Klingensmith, J."

The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness by Klingensmith, Nathan J., MD, Coopersmith, Craig M., MD

“…All elements of the gut - the epithelium, the immune system, and the microbiome - are impacted by critical illness and can, in turn, propagate a pathologic…”
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Mechanisms of Intestinal Barrier Dysfunction in Sepsis by Yoseph, Benyam P, Klingensmith, Nathan J, Liang, Zhe, Breed, Elise R, Burd, Eileen M, Mittal, Rohit, Dominguez, Jessica A, Petrie, Benjamin, Ford, Mandy L, Coopersmith, Craig M

“…ABSTRACTIntestinal barrier dysfunction is thought to contribute to the development of multiple organ dysfunction syndrome in sepsis. Although there are…”
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Effect of Remote Ischemic Preconditioning on Outcomes in Adult Cardiac Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Studies by Xie, Jianfeng, Zhang, Xiwen, Xu, Jingyuan, Zhang, Zhongheng, Klingensmith, Nathan J., Liu, Songqiao, Pan, Chun, Yang, Yi, Qiu, Haibo

“…BACKGROUND:Remote ischemic preconditioning (RIPC) has been demonstrated to prevent organ dysfunction in cardiac surgery patients. However, recent large,…”
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Political entrepreneurs and pork-barrel spending by Klingensmith, J. Zachary

“…Pork-barrel spending is the use of federal money for localized projects that yield only a narrow geographic benefit. It is a commonly held belief that…”
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Using tax dollars for re-election: the impact of pork-barrel spending on electoral success by Klingensmith, J. Zachary

“…Pork-barrel spending is the appropriation of federal money for use in projects that only benefit narrowly defined groups. In the past, researchers have…”
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Overexpression of BCL-2 in the Intestinal Epithelium Prevents Sepsis-Induced Gut Barrier Dysfunction via Altering Tight Junction Protein Expression by Otani, Shunsuke, Oami, Takehiko, Yoseph, Benyam P., Klingensmith, Nathan J., Chen, Ching-wen, Liang, Zhe, Coopersmith, Craig M.

“…ABSTRACTSepsis induces both intestinal hyperpermeability and epithelial apoptosis. While each has been implicated in mediating sepsis mortality, the…”
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Glycemic Control in Youth with Diabetes: The SEARCH for Diabetes in Youth Study by Petitti, Diana B., MD, MPH, Klingensmith, Georgeanna J., MD, Bell, Ronny A., PhD, MS, Andrews, Jeanette S., MS, Dabelea, Dana, MD, PhD, Imperatore, Giuseppina, MD, PhD, Marcovina, Santica, PhD, Pihoker, Catherine, MD, Standiford, Debra, MSN, CNP, Waitzfelder, Beth, PhD, Mayer-Davis, Elizabeth, PhD

“…Objective To assess correlates of glycemic control in a diverse population of children and youth with diabetes. Study design This was a cross-sectional…”
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Human red blood cells express the RNA sensor TLR7 by Metthew Lam, L. K., Oatman, Emily, Eckart, Kaitlyn A., Klingensmith, Nathan J., Flowers, Emily, Sayegh, Layal, Yuen, Julia, Clements, Rebecca L., Meyer, Nuala J., Jurado, Kellie A., Vaughan, Andrew E., Eisenbarth, Stephanie C., Mangalmurti, Nilam S.

“…Red blood cells (RBCs) express the nucleic acid-binding toll-like receptor 9 (TLR9) and bind CpG-containing DNA. However, whether human RBCs express other…”
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CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis by Ramonell, Kimberly M, Zhang, Wenxiao, Hadley, Annette, Chen, Ching-Wen, Fay, Katherine T, Lyons, John D, Klingensmith, Nathan J, McConnell, Kevin W, Coopersmith, Craig M, Ford, Mandy L

“…Sepsis is a dysregulated systemic response to infection involving many inflammatory pathways and the induction of counter-regulatory anti-inflammatory…”
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Demographic and Clinical Correlates of Diabetes-Related Quality of Life among Youth with Type 1 Diabetes by Lawrence, Jean M., ScD, MPH, MSSA, Yi-Frazier, Joyce P., PhD, Black, Mary Helen, PhD, Anderson, Andrea, MS, Hood, Korey, PhD, Imperatore, Giuseppina, MD, PhD, Klingensmith, Georgeanna J., MD, Naughton, Michelle, PhD, Mayer-Davis, Elizabeth J., PhD, Seid, Michael, PhD

“…Objectives To evaluate the reliability and cluster structure of the Pediatric Quality of Life Inventory Type 1 Diabetes Module 3.0 (PedsQL-T1DM) and associated…”
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Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis by Lorentz, C Adam, Liang, Zhe, Meng, Mei, Chen, Ching-Wen, Yoseph, Benyam P, Breed, Elise R, Mittal, Rohit, Klingensmith, Nathan J, Farris, Alton B, Burd, Eileen M, Koval, Michael, Ford, Mandy L, Coopersmith, Craig M

“…Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the peri-junctional…”
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Diabetic Ketoacidosis at Diabetes Onset: Still an All Too Common Threat in Youth by Klingensmith, Georgeanna J., MD, Tamborlane, William V., MD, Wood, Jamie, MD, Haller, Michael J., MD, Silverstein, Janet, MD, Cengiz, Eda, MD, Shanmugham, Satya, BS, Kollman, Craig, PhD, Wong-Jacobson, Siew, MPH, Beck, Roy W., MD, PhD

“…Objective To define the demographic and clinical characteristics of children at the onset of type 1 diabetes (T1D), with particular attention to the frequency…”
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Increased mortality in CD43-deficient mice during sepsis by Fay, Katherine T, Chihade, Deena B, Chen, Ching-Wen, Klingensmith, Nathan J, Lyons, John D, Ramonell, Kimberly, Liang, Zhe, Coopersmith, Craig M, Ford, Mandy L

“…CD43 is a large transmembrane protein involved in T cell activation. Previous studies of CD43-/- mice in viral models have demonstrated a role for CD43 in…”
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Initial Presentation of Type 2 Diabetes in Adolescents Predicts Durability of Successful Treatment with Metformin Monotherapy: Insights from the Pediatric Diabetes Consortium T2D Registry by Bacha, Fida, Cheng, Peiyao, Gal, Robin L, Kollman, Craig, Tamborlane, William V, Klingensmith, Georgeanna J, Manseau, Katherine, Wood, Jamie, Beck, Roy W

“…Many adolescents with type 2 diabetes (T2D) have rapid deterioration of glycemic control on metformin monotherapy within 2 years of diagnosis. Enrollment data…”
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Longitudinal Associations between Sex, Diabetes Self-Care, and Health-Related Quality of Life among Youth with Type 1 or Type 2 Diabetes Mellitus by Naughton, Michelle J., PhD, MPH, Yi-Frazier, Joyce P., PhD, Morgan, Timothy M., PhD, Seid, Michael, PhD, Lawrence, Jean M., ScD, MPH, MSSA, Klingensmith, Georgeanna J., MD, Waitzfelder, Beth, PhD, Standiford, Debra A., MSN, Loots, Beth, MPH, MSW

“…Objective To examine the longitudinal associations between sex, diabetes self-care, and the health-related quality of life (HRQL) of children and adolescents…”
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Height growth velocity, islet autoimmunity and type 1 diabetes development: the Diabetes Autoimmunity Study in the Young by Lamb, M. M, Yin, X, Zerbe, G. O, Klingensmith, G. J, Dabelea, D, Fingerlin, T. E, Rewers, M, Norris, J. M

“…Aims/hypothesis Larger childhood body size and rapid growth have been associated with increased type 1 diabetes risk. We analysed height, weight, BMI and…”
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Trends in High-Risk HLA Susceptibility Genes Among Colorado Youth With Type 1 Diabetes by Vehik, Kendra, Hamman, Richard F, Lezotte, Dennis, Norris, Jill M, Klingensmith, Georgeanna J, Rewers, Marian, Dabelea, Dana

“…OBJECTIVE:--Type 1 diabetes is associated with a wide spectrum of susceptibility and protective genotypes within the HLA class II system. It has been reported…”
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Reduced Bone Mineral Density Is Associated with Celiac Disease Autoimmunity in Children with Type 1 Diabetes by Simmons, Kimber M., MD, McFann, Kim, PhD, Taki, Iman, BS, Liu, Edwin, MD, Klingensmith, Georgeanna J., MD, Rewers, Marian J., MD, PhD, Frohnert, Brigitte I., MD, PhD

“…Objective To evaluate the association between bone mineral density (BMD), glycemic control (hemoglobin A1c [HbA1c]), and celiac autoimmunity in children with…”
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Randomized Nutrition Education Intervention to Improve Carbohydrate Counting in Adolescents with Type 1 Diabetes Study: Is More Intensive Education Needed? by Spiegel, Gail, MS, RD, Bortsov, Andrey, MD, PhD, Bishop, Franziska K., MS, Owen, Darcy, MS, RD, Klingensmith, Georgeanna J., MD, Mayer-Davis, Elizabeth J., PhD, RD, Maahs, David M., MD, PhD

“…Abstract Background Youth with type 1 diabetes do not count carbohydrates accurately, yet it is an important strategy in blood glucose control. Objective The…”
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Predictors of Loss to Follow-Up among Children with Type 2 Diabetes by Shoemaker, Ashley, Cheng, Peiyao, Gal, Robin L, Kollman, Craig, Tamborlane, William V, Klingensmith, Georgeanna J, Clements, Mark A, Hannon, Tamara S, Heptulla, Rubina, Less, Joane, Wood, Jamie

“…Youth with type 2 diabetes (T2D) have poor compliance with medical care. This study aimed to determine which demographic and clinical factors differ between…”
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