Search Results - "Klinge, C M"

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene by Lu, Z, Liu, M, Stribinskis, V, Klinge, C M, Ramos, K S, Colburn, N H, Li, Y

“…MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively control expression of target genes in animals and plants. The microRNA-21 gene ( mir-21 )…”
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Estrogen receptor interaction with estrogen response elements by Klinge, C M

“…The estrogen receptor (ER) is a ligand-activated enhancer protein that is a member of the steroid/nuclear receptor superfamily. Two genes encode mammalian ER:…”
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Estrogen receptor interaction with co-activators and co-repressors by Klinge, Carolyn M

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Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors α and β by coactivators and corepressors by Klinge, C M, Jernigan, S C, Mattingly, K A, Risinger, K E, Zhang, J

“…One mechanism by which ligand-activated estrogen receptors α and β (ERα and ERβ) stimulate gene transcription is through direct ER interaction with specific…”
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Response element sequence modulates estrogen receptor alpha and beta affinity and activity by Kulakosky, PC, McCarty, MA, Jernigan, SC, Risinger, KE, Klinge, CM

“…The relationship between estrogen receptor (ER)-estrogen response element (ERE) binding affinity and estradiol (E(2))-induced transcription has not been…”
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Role of estrogen receptor ligand and estrogen response element sequence on interaction with chicken ovalbumin upstream promoter transcription factor (COUP-TF) by Klinge, Carolyn M.

“…Estrogen-responsive genes are regulated by altering the balance of estrogen receptor (ER) interaction with transcription activators and inhibitors. Here we…”
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Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta by Bowers, J L, Tyulmenkov, V V, Jernigan, S C, Klinge, C M

“…Epidemiological evidence indicates that phytoestrogens inhibit cancer formation and growth, reduce cholesterol levels, and show benefits in treating…”
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Estrogen receptor binding to estrogen response elements slows ligand dissociation and synergistically activates reporter gene expression by Klinge, Carolyn M

“…Estradiol (E 2)-liganded estrogen receptor (ER) bound to three or four tandem copies of a consensus ERE (EREc38) in a cooperative manner. E 2-ER binding to one…”
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Short Heterodimer Partner (SHP) Orphan Nuclear Receptor Inhibits the Transcriptional Activity of Aryl Hydrocarbon Receptor (AHR)/AHR Nuclear Translocator (ARNT) by Klinge, Carolyn M., Jernigan, Sarah C., Risinger, Kelly E., Lee, Jennie E., Tyulmenkov, Valentyn V., Falkner, K.Cameron, Prough, Russell A.

“…SHP (short heterodimer partner) is an orphan nuclear receptor lacking a DNA binding domain that interacts with nuclear receptors (NR) including thyroid…”
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A mathematical approach to predict the affinity of estrogen receptors α and β binding to DNA by Tyulmenkov, Valentyn V, Klinge, Carolyn M

“…Estrogen receptors α and β (ERα and ERβ) bind to specific DNA sequences, estrogen response elements (EREs), usually located in the promoters of…”
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Chicken Ovalbumin Upstream Promoter-Transcription Factor Interacts with Estrogen Receptor, Binds to Estrogen Response Elements and Half-Sites, and Inhibits Estrogen-induced Gene Expression by Klinge, Carolyn M., Silver, Bethany F., Driscoll, Mark D., Sathya, Ganesan, Bambara, Robert A., Hilf, Russell

“…Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) was identified as a low abundance protein in bovine uterus that co-purified with estrogen…”
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Estrogen Receptors α and β Exhibit Different Estradiol and Estrogen Response Element Binding in the Presence of Nonspecific DNA by Tyulmenkov, Valentyn V., Klinge, Carolyn M.

“…Estrogen receptors (ER) α and β bind estradiol (E2) and estrogen response element (ERE) DNA sequences with high affinities. The different migration of ER–ERE…”
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Estrogen response element binding induces alterations in estrogen receptor-alpha conformation as revealed by susceptibility to partial proteolysis by Ramsey, TL, Klinge, CM

“…Genes whose expression is highly induced by estradiol (E(2)) contain multiple estrogen response elements (EREs) in their promoters. Previously we reported that…”
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Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells by Thomas, T, Shah, N, Klinge, CM, Faaland, CA, Adihkarakunnathu, S, Gallo, MA, Thomas, TJ

“…We investigated the effects of polyamine biosynthesis inhibition on the estrogenic signaling pathway of MCF-7 breast cancer cells using a protein-protein…”
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Effects of multiple estrogen responsive elements, their spacing, and location on estrogen response of reporter genes by Sathya, G, Li, W, Klinge, C M, Anolik, J H, Hilf, R, Bambara, R A

“…Most highly estrogen-responsive genes possess multiple estrogen-responsive elements (EREs) that act synergistically to activate expression. Synergism between…”
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Stability of the ligand-estrogen receptor interaction depends on estrogen response element flanking sequences and cellular factors by Anolik, Jennifer H., Klinge, Carolyn M., Brolly, Colleen L., Bambara, Robert A., Hilf, Russell

“…To determine whether accessory proteins mediate the ligand- and DNA sequence-dependent specificity of estrogen receptor (ER) interaction with DNA, the binding…”
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hsp70 is not required for high affinity binding of purified calf uterine estrogen receptor to estrogen response element DNA in Vitro by Klinge, Carolyn M., Brolly, Colleen L., Bambara, Robert A., Hilf, Russell

“…Bovine estrogen receptor (ER) was purified to near homogeneity by estrogen response element (ERE) affinity chromatography, and its ERE binding ability was…”
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Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells by Lewis, JS, Thomas, TJ, Klinge, CM, Gallo, MA, Thomas, T

“…It has been suggested that alterations in estradiol (E(2)) metabolism, resulting in increased production of 16alpha-hydroxyestrone (16alpha-OHE(1)), is…”
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Dissociation of 4-hydroxytamoxifen, but not estradiol or tamoxifen aziridine, from the estrogen receptor as the receptor binds estrogen response element DNA by Klinge, Carolyn M., Traish, Abdulmaged M., Bambara, Robert A., Hilf, Russell

“…Estradiol-liganded estrogen receptor (E 2-ER) binds EREs with a stoichiometry of one E 2-ER dimer per estrogen response element (ERE). In contrast, although…”
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Antiandrogenic Activities of Diesel Exhaust Particle Extracts in PC3/AR Human Prostate Carcinoma Cells by Kizu, Ryoichi, Okamura, Kazumasa, Toriba, Akira, Mizokami, Atsushi, Burnstein, Kerry L., Klinge, Carolyn M., Hayakawa, Kazuichi

“…We collected diesel exhaust particles (DEPs) emitted from three diesel-engine vehicles—a car, a bus, and a truck—in daily use, and prepared DEP extracts…”
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