Search Results - "Klingbeil, Kristina M"

Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives by Perni, Robert B, Wentland, Mark P, Huang, Jianhua I, Powles, Ronald G, Aldous, Suzanne, Klingbeil, Kristina M, Peverly, A. Danielle, Robinson, Ronald G, Corbett, Thomas H, Jones, Julie L, Mattes, Kenneth C, Rake, James B, Coughlin, Susan A

“…Two new series of antitumor agents, 4-aminomethylthioxanthenones (6 − 50) and 5-aminomethylbenzothiopyranoindazoles (51 − 61), are described and compared…”
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Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161) by COUGHLIN, S. A, DANZ, D. W, RAKE, J. B, ROBINSON, R. G, KLINGBEIL, K. M, WENTLAND, M. P, CORBETT, T. H, WAUD, W. R, ZWELLING, L. A, ALTSCHULER, E, BALES, E

“…(S)-10-(2,6-Dimethyl-4-pyridinyl) 9-fluoro-3-methyl-7-oxo 2,3-dihydro-7H-pyrido[1,2,3-de] [1,4]benzothiazine-6-carboxylic acid (WIN 58161) is an…”
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The antitumor activity of novel pyrazoloquinoline derivatives by Wentland, Mark P., Aldous, Suzanne C., Gruett, Monte D., Perni, Robert B., Powles, Ronald G., Danz, Deborah W., Klingbeil, Kristina M., Peverly, A.Danielle, Robinson, Ronald G., Corbett, Thomas H., Rake, James B., Coughlin, Susan A.

“…Mammalian topoisomerase II inhibition activity has been identified in a series of novel pyrazoloquinoline derivatives; potency for two analogues containing…”
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3-benzyl-quinolones: Novel, potent inhibitors of mammalian topoisomerase II by Eissenstat, Michael A., Kuo, Gee-Hong, Weaver, John D., Wentland, Mark P., Robinson, Ronald G., Klingbeil, Kristina M., Danz, Deborah W., Corbett, Thomas H., Coughlin, Susan A.

“…Replacement of the 3-carboxy group of quinolone topoisomerase II inhibitors by hydroxy substituted benzyl groups resulted in potent topoisomerase II…”
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Cyclic variations of SR 233377 (WIN 33377) and effects on antitumor activity by Wentland, Mark P., Perni, Robert B., Huang, Jianhua I., Powles, Ronald G., Aldous, Suzanne C., Klingbeil, Kristina M., Danielle Peverly, A., Robinson, Ronald G., Corbett, Thomas H., Jones, Julie L., Rake, James B., Coughlin, Susan A.

“…Novel derivatives of SR 233377 ( 1, WIN 33377) where a pyrazolo ring fusion has been incorporated at the 1- and 9-positions of the thioxanthone ring displayed…”
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Potent mammalian topoisomerase II inhibitors: 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-substituted-quinolines by Kuo, Gee-Hong, Eissenstat, Michael A., Wentland, Mark P., Robinson, Ron G., Klingbeil, Kristina M., Danz, Debbie W., Coughlin, Susan A.

“…A series of novel 4-substituted-1,4-dihydro-quinolines 3 were prepared and found to exhibit moderate to excellent mammalian topo II inhibitory activity. Among…”
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Mechanism of action and antitumor activity of ( S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H-pyridol [1,2,3- de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161) by Coughlin, Susan A., Danz, Deborah W., Robinson, Ronald G., Klingbeil, Kristina M., Wentland, Mark P., Corbett, Thomas H., Waud, William R., Zwelling, Leonard A., Altschuler, Elizabeth, Bales, Elise, Rake, James B.

“…( S)-10-(2,6-Dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H-pyrido[1,2,3 de][1,4] benzothiazine-6-carboxylic acid (WIN 58161) is an…”
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