Search Results - "Kling, Lothar"

A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies by Stracke, Jan, Emrich, Thomas, Rueger, Petra, Schlothauer, Tilman, Kling, Lothar, Knaupp, Alexander, Hertenberger, Hubert, Wolfert, Andreas, Spick, Christian, Lau, Wilma, Drabner, Georg, Reiff, Ulrike, Koll, Hans, Papadimitriou, Apollon

“…Preserving the chemical and structural integrity of therapeutic antibodies during manufacturing and storage is a major challenge during pharmaceutical…”
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Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies by Schlothauer, Tilman, Rueger, Petra, Stracke, Jan Olaf, Hertenberger, Hubert, Fingas, Felix, Kling, Lothar, Emrich, Thomas, Drabner, Georg, Seeber, Stefan, Auer, Johannes, Koch, Stefan, Papadimitriou, Apollon

“…The neonatal Fc receptor (FcRn) is important for the metabolic fate of IgG antibodies in vivo. Analysis of the interaction between FcRn and IgG in vitro might…”
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Clinical chemistry of human FcRn transgenic mice by Stein, Carsten, Kling, Lothar, Proetzel, Gabriele, Roopenian, Derry C., de Angelis, Martin Hrabě, Wolf, Eckhard, Rathkolb, Birgit

“…Mice genetically engineered to express human FcRn are valuable models for the evaluation of therapeutic antibodies in the context of human FcRn in vivo…”
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Effects of angiotensin II on bone cells in vitro by Lamparter, Steffen, Kling, Lothar, Schrader, Michael, Ziegler, Reinhard, Pfeilschifter, Johannes

“…Other than its known effects on the cardiovascular system, angiotensin II (Ang II) stimulates cell growth in several cell types. In this study, we examined…”
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DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity by Sustmann, Claudio, Dickopf, Steffen, Regula, Jörg T, Kettenberger, Hubert, Mølhøj, Michael, Gassner, Christian, Weininger, Diana, Fenn, Sebastian, Manigold, Tobias, Kling, Lothar, Künkele, Klaus-Peter, Schwaiger, Manfred, Bossenmaier, Birgit, Griese, Julia J, Hopfner, Karl-Peter, Graff-Meyer, Alexandra, Stahlberg, Henning, Ringler, Philippe, Lauer, Matthias E, Brinkmann, Ulrich, Schaefer, Wolfgang, Klein, Christian

“…High specificity accompanied with the ability to recruit immune cells has made recombinant therapeutic antibodies an integral part of drug development. Here we…”
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Development of tetravalent IgG1 dual targeting IGF-1R–EGFR antibodies with potent tumor inhibition by Croasdale, Rebecca, Wartha, Katharina, Schanzer, Juergen M., Kuenkele, Klaus-Peter, Ries, Carola, Mayer, Klaus, Gassner, Christian, Wagner, Martina, Dimoudis, Nikolaos, Herter, Sylvia, Jaeger, Christiane, Ferrara, Claudia, Hoffmann, Eike, Kling, Lothar, Lau, Wilma, Staack, Roland F., Heinrich, Julia, Scheuer, Werner, Stracke, Jan, Gerdes, Christian, Brinkmann, Ulrich, Umana, Pablo, Klein, Christian

“…► Enhanced EGFR downregulation mediated by the XGFR bispecific antibodies. ► Novel bispecific format related effects upon ADCC induction. ► Potent induction of…”
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PK modulation of haptenylated peptides via non-covalent antibody complexation by Hoffmann, Eike, Konkar, Anish, Dziadek, Sebastian, Josel, Hans-Peter, Conde-Knape, Karin, Kropp, Holger, Kling, Lothar, Stubenrauch, Kay, Thorey, Irmgard, Dengl, Stefan, Brinkmann, Ulrich

“…We applied noncovalent complexes of digoxigenin (Dig) binding antibodies with digoxigeninylated peptide derivatives to modulate their pharmacokinetic…”
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DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity by Sustmann, Claudio, Dickopf, Steffen, Regula, Jörg T., Kettenberger, Hubert, Mølhøj, Michael, Gassner, Christian, Weininger, Diana, Fenn, Sebastian, Manigold, Tobias, Kling, Lothar, Künkele, Klaus-Peter, Schwaiger, Manfred, Bossenmaier, Birgit, Griese, Julia J., Hopfner, Karl-Peter, Graff-Meyer, Alexandra, Stahlberg, Henning, Ringler, Philippe, Lauer, Matthias E., Brinkmann, Ulrich, Schaefer, Wolfgang, Klein, Christian

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Effect of the new matrix metalloproteinase inhibitor RO-28-2653 on mitochondrial function by Opalka, Jens R., Gellerich, Frank N., Kling, Lothar, Müller-Beckmann, Bernd, Zierz, Stephan

“…Matrix metalloproteinases (MMPs) have recently become interesting as potential anticancer drugs. RO-28-2653 is a promising compound because of its…”
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DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity by Sustmann, Claudio, Dickopf, Steffen, Regula, Jörg T., Kettenberger, Hubert, Mølhøj, Michael, Gassner, Christian, Weininger, Diana, Fenn, Sebastian, Manigold, Tobias, Kling, Lothar, Künkele, Klaus-Peter, Schwaiger, Manfred, Bossenmaier, Birgit, Griese, Julia J., Hopfner, Karl-Peter, Graff-Meyer, Alexandra, Stahlberg, Henning, Ringler, Philippe, Lauer, Matthias E., Brinkmann, Ulrich, Schaefer, Wolfgang, Klein, Christian

“…High specificity accompanied with the ability to recruit immune cells has made recombinant therapeutic antibodies an integral part of drug development. Here we…”
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A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies by Stracke, Jan, Emrich, Thomas, Rueger, Petra, Schlothauer, Tilman, Kling, Lothar, Knaupp, Alexander, Hertenberger, Hubert, Wolfert, Andreas, Spick, Christian, Lau, Wilma, Drabner, Georg, Reiff, Ulrike, Koll, Hans, Papadimitriou, Apollon

“…Preserving the chemical and structural integrity of therapeutic antibodies during manufacturing and storage is a major challenge during pharmaceutical…”
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Nonsteroidal cardiotonics. 3. New 4,5-dihydro-6-(1H-indol-5-yl)pyridazin-3(2H)-ones and related compounds with positive inotropic activities by Mertens, Alfred, Friebe, Walter Gunar, Mueller-Beckmann, Bernd, Kampe, Wolfgang, Kling, Lothar, Von der Saal, Wolfgang

“…A series of substituted indolyldihydropyridazinones and related compounds 1-18 were synthesized and evaluated for positive inotropic activity. In rats, most of…”
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Ca2+-sensitizing effect of BM 14.478 on skinned cardiac muscle fibres of guinea-pig papillary muscle by Freund, P, Müller-Beckmann, B, Strein, K, Kling, L, Rüegg, J C

“…A concentration-dependent increase in force development was obtained with BM 14.478 (10(-9)-5 X 10(-4) M) in skinned fibres of guinea-pig papillary muscles…”
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