Search Results - "Klinedinst, Susan"
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Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation
Published in Nature chemical biology (01-02-2013)“…An allosteric activator of Hsp70 mimics Hip and reduces neurotoxicity in a model for spinobulbar muscular atrophy by promoting ubiquitination and degradation…”
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Journal Article -
2
Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104
Published in eLife (19-09-2017)“…The kinesin-3 family member Unc-104/KIF1A is required for axonal transport of many presynaptic components to synapses, and mutation of this gene results in…”
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Journal Article -
3
Gata factor Pannier is required to establish competence for heart progenitor formation
Published in Development (Cambridge) (01-07-2003)“…Inductive signaling is of pivotal importance for developmental patterns to form. In Drosophila , the transfer of TGFβ (Dpp) and Wnt (Wg) signaling information…”
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Journal Article -
4
ATP-sensitive potassium (K(ATP)) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman
Published in Proceedings of the National Academy of Sciences - PNAS (08-08-2006)“…The homeobox transcription factor Tinman plays an important role in the initiation of heart development. Later functions of Tinman, including the target genes…”
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Journal Article -
5
A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones
Published in eLife (14-08-2015)“…Synaptic vesicles (SVs) fuse at active zones (AZs) covered by a protein scaffold, at Drosophila synapses comprised of ELKS family member Bruchpilot (BRP) and…”
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Journal Article -
6
Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling
Published in The Journal of neuroscience (31-07-2013)“…Mitogen-activated protein (MAP) kinase signaling cascades orchestrate diverse cellular activities with common molecular players. To achieve specific cellular…”
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Journal Article -
7
A xenobiotic-stress-activated transcription factor and its cognate target genes are preferentially expressed in root tip meristems
Published in Plant molecular biology (01-03-2000)“…In plants, as-1-type cis elements and their trans-acting factors confer tissue-specific and signal-responsive activities to the promoters of several…”
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Journal Article -
8
how functions in leg development during Drosophila metamorphosis
Published in Developmental dynamics (01-08-2006)“…The Drosophila how gene encodes a KH RNA binding protein with strong similarity to GLD‐1 from nematodes and QK1 from mice. Here, we investigate the function of…”
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Journal Article -
9
Influences that affect dangerous drinking of alcohol as reported by intercollegiate athletes at a small college in southeastern Pennsylvania
Published 01-01-2008“…This quantitative descriptive study collected data on the influences of alcohol use and dangerous alcohol use as reported by 205 Caucasian athletes who…”
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Dissertation -
10
The functions of the GATA factor pannier and its partner u-shaped in specifying the Drosophila heart
Published 01-01-2006“…In Drosophila, heart progenitors arise from bilaterally symmetric positions in the dorsal mesoderm which migrate toward the dorsal midline and fuse to form a…”
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Dissertation