Search Results - "Kline, Crystal F."

SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia by Musa, Hassan, Kline, Crystal F, Sturm, Amy C, Murphy, Nathaniel, Adelman, Sara, Wang, Chaojian, Yan, Haidun, Johnson, Benjamin L, Csepe, Thomas A, Kilic, Ahmet, Higgins, Robert S D, Janssen, Paul M L, Fedorov, Vadim V, Weiss, Raul, Salazar, Christina, Hund, Thomas J, Pitt, Geoffrey S, Mohler, Peter J

“…Nav channels are essential for metazoan membrane depolarization, and Nav channel dysfunction is directly linked with epilepsy, ataxia, pain, arrhythmia,…”
Get full text

βIV-Spectrin and CaMKII facilitate Kir6.2 regulation in pancreatic beta cells by Kline, Crystal F., Wright, Patrick J., Koval, Olha M., Zmuda, Erik J., Johnson, Benjamin L., Anderson, Mark E., Hai, Tsonwin, Hund, Thomas J., Mohler, Peter J.

“…Identified over a dozen years ago in the brain and pancreatic islet, β IV-spectrin is critical for the local organization of protein complexes throughout the…”
Get full text

Common human ANK2 variant confers in vivo arrhythmia phenotypes by Musa, Hassan, PhD, Murphy, Nathaniel P., BS, Curran, Jerry, PhD, Higgins, John D., BS, Webb, Tyler R, Makara, Michael A., PhD, Wright, Patrick, BS, Lancione, Peter J., BS, Lubbers, Ellen R., BS, Healy, Jane A., BS, Smith, Sakima A., MD, Bennett, Vann, MD, PhD, Hund, Thomas J., PhD, Kline, Crystal F., PhD, Mohler, Peter J., PhD

“…Background Human ANK2 (ankyrin-B) loss-of-function variants are directly linked with arrhythmia phenotypes. However, in atypical non–ion channel arrhythmia…”
Get full text

Dual role of KATP channel C-terminal motif in membrane targeting and metabolic regulation by Kline, Crystal F, Kurata, Harley T, Hund, Thomas J, Cunha, Shane R, Koval, Olha M, Wright, Patrick J, Christensen, Matthew, Anderson, Mark E, Nichols, Colin G, Mohler, Peter J

“…The coordinated sorting of ion channels to specific plasma membrane domains is necessary for excitable cell physiology. KATP channels, assembled from…”
Get full text

Altered Expression of Zonula occludens-1 Affects Cardiac Na + Channels and Increases Susceptibility to Ventricular Arrhythmias by El Refaey, Mona, Coles, Sara, Musa, Hassan, Stevens, Tyler L, Wallace, Michael J, Murphy, Nathaniel P, Antwi-Boasiako, Steve, Young, Lindsay J, Manring, Heather R, Curran, Jerry, Makara, Michael A, Sas, Kelli, Han, Mei, Koenig, Sara N, Skaf, Michel, Kline, Crystal F, Janssen, Paul M L, Accornero, Federica, Borzok, Maegen A, Mohler, Peter J

“…Zonula occludens-1 (ZO-1) is an intracellular scaffolding protein that orchestrates the anchoring of membrane proteins to the cytoskeleton in epithelial and…”
Get full text

Regulation of Cardiac ATP-sensitive Potassium Channel Surface Expression by Calcium/Calmodulin-dependent Protein Kinase II by Sierra, Ana, Zhu, Zhiyong, Sapay, Nicolas, Sharotri, Vikas, Kline, Crystal F., Luczak, Elizabeth D., Subbotina, Ekaterina, Sivaprasadarao, Asipu, Snyder, Peter M., Mohler, Peter J., Anderson, Mark E., Vivaudou, Michel, Zingman, Leonid V., Hodgson-Zingman, Denice M.

“…Cardiac ATP-sensitive potassium (KATP) channels are key sensors and effectors of the metabolic status of cardiomyocytes. Alteration in their expression impacts…”
Get full text

Use of Whole Exome Sequencing for the Identification of Ito‐Based Arrhythmia Mechanism and Therapy by Sturm, Amy C., Kline, Crystal F., Glynn, Patric, Johnson, Benjamin L., Curran, Jerry, Kilic, Ahmet, Higgins, Robert S. D., Binkley, Philip F., Janssen, Paul M. L., Weiss, Raul, Raman, Subha V., Fowler, Steven J., Priori, Silvia G., Hund, Thomas J., Carnes, Cynthia A., Mohler, Peter J.

“…Background Identified genetic variants are insufficient to explain all cases of inherited arrhythmia. We tested whether the integration of whole exome…”
Get full text

Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence by Mohler, Peter J, Healy, Jane A, Xue, Hui, Puca, Annibale A, Kline, Crystal F, Allingham, R Rand, Kranias, Evangelia G, Rockman, Howard A, Bennett, Vann

“…Here we report the unexpected finding that specific human ANK2 variants represent a new example of balanced human variants. The prevalence of certain ANK2…”
Get full text

A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice by Hund, Thomas J, Koval, Olha M, Li, Jingdong, Wright, Patrick J, Qian, Lan, Snyder, Jedidiah S, Gudmundsson, Hjalti, Kline, Crystal F, Davidson, Nathan P, Cardona, Natalia, Rasband, Matthew N, Anderson, Mark E, Mohler, Peter J

“…Ion channel function is fundamental to the existence of life. In metazoans, the coordinate activities of voltage-gated Na(+) channels underlie cellular…”
Get full text

Ankyrin regulates KATP channel membrane trafficking and gating in excitable cells by Kline, Crystal F., Hund, Thomas J., Mohler, Peter J.

“…KATP channels play critical roles in many cellular functions by coupling cell metabolic status to electrical activity. First discovered in cardiomyocytes 1,…”
Get full text

Defining the molecular signatures of human right heart failure by Williams, Jordan L., Cavus, Omer, Loccoh, Emefah C., Adelman, Sara, Daugherty, John C., Smith, Sakima A., Canan, Benjamin, Janssen, Paul M.L., Koenig, Sara, Kline, Crystal F., Mohler, Peter J., Bradley, Elisa A.

“…Right ventricular failure (RVF) varies significantly from the more common left ventricular failure (LVF). This study was undertaken to determine potential…”
Get full text

Ankyrin-B Regulates Cav2.1 and Cav2.2 Channel Expression and Targeting by Kline, Crystal F., Scott, John, Curran, Jerry, Hund, Thomas J., Mohler, Peter J.

“…N-type and P/Q-type calcium channels are documented players in the regulation of synaptic function; however, the mechanisms underlying their expression and…”
Get full text

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia by Smith, Sakima A, Sturm, Amy C, Curran, Jerry, Kline, Crystal F, Little, Sean C, Bonilla, Ingrid M, Long, Victor P, Makara, Michael, Polina, Iuliia, Hughes, Langston D, Webb, Tyler R, Wei, Zhiyi, Wright, Patrick, Voigt, Niels, Bhakta, Deepak, Spoonamore, Katherine G, Zhang, Chuansheng, Weiss, Raul, Binkley, Philip F, Janssen, Paul M, Kilic, Ahmet, Higgins, Robert S, Sun, Mingzhai, Ma, Jianjie, Dobrev, Dobromir, Zhang, Mingjie, Carnes, Cynthia A, Vatta, Matteo, Rasband, Matthew N, Hund, Thomas J, Mohler, Peter J

“…The cardiac cytoskeleton plays key roles in maintaining myocyte structural integrity in health and disease. In fact, human mutations in cardiac cytoskeletal…”
Get full text

Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome by Swayne, Leigh Anne, Murphy, Nathaniel P, Asuri, Sirisha, Chen, Lena, Xu, Xiaoxue, McIntosh, Sarah, Wang, Chao, Lancione, Peter J, Roberts, Jason D, Kerr, Charles, Sanatani, Shubhayan, Sherwin, Elizabeth, Kline, Crystal F, Zhang, Mingjie, Mohler, Peter J, Arbour, Laura T

“…BACKGROUND—Long QT syndrome confers susceptibility to ventricular arrhythmia, predisposing to syncope, seizures, and sudden death. While rare globally, long QT…”
Get full text

Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart by Little, Sean C, Curran, Jerry, Makara, Michael A, Kline, Crystal F, Ho, Hsiang-Ting, Xu, Zhaobin, Wu, Xiangqiong, Polina, Iuliia, Musa, Hassan, Meadows, Allison M, Carnes, Cynthia A, Biesiadecki, Brandon J, Davis, Jonathan P, Weisleder, Noah, Györke, Sandor, Wehrens, Xander H, Hund, Thomas J, Mohler, Peter J

“…Protein phosphatase 2A (PP2A) is a serine/threonine-selective holoenzyme composed of a catalytic, scaffolding, and regulatory subunit. In the heart, PP2A…”
Get more information

Defective interactions of protein partner with ion channels and transporters as alternative mechanisms of membrane channelopathies by Kline, Crystal F., Mohler, Peter J.

“…The past twenty years have revealed the existence of numerous ion channel mutations resulting in human pathology. Ion channels provide the basis of diverse…”
Get full text

Ankyrin-B Regulates Kir6.2 Membrane Expression and Function in Heart by Li, Jingdong, Kline, Crystal F., Hund, Thomas J., Anderson, Mark E., Mohler, Peter J.

“…Ankyrin polypeptides are critical for normal membrane protein expression in diverse cell types, including neurons, myocytes, epithelia, and erythrocytes…”
Get full text

Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells by Neshatian, Leila, Strege, Peter R, Rhee, Poong-Lyul, Kraichely, Robert E, Mazzone, Amelia, Bernard, Cheryl E, Cima, Robert R, Larson, David W, Dozois, Eric J, Kline, Crystal F, Mohler, Peter J, Beyder, Arthur, Farrugia, Gianrico

“…Human jejunum smooth muscle cells (SMCs) and interstitial cells of Cajal (ICCs) express the SCN5A-encoded voltage-gated, mechanosensitive sodium channel…”
Get more information

Dysfunction of the β2-spectrin-based pathway in human heart failure by Smith, Sakima A, Hughes, Langston D, Kline, Crystal F, Kempton, Amber N, Dorn, Lisa E, Curran, Jerry, Makara, Michael, Webb, Tyler R, Wright, Patrick, Voigt, Niels, Binkley, Philip F, Janssen, Paul M L, Kilic, Ahmet, Carnes, Cynthia A, Dobrev, Dobromir, Rasband, Matthew N, Hund, Thomas J, Mohler, Peter J

“…β2-Spectrin is critical for integrating membrane and cytoskeletal domains in excitable and nonexcitable cells. The role of β2-spectrin for vertebrate function…”
Get more information

Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria by Curran, Jerry, Musa, Hassan, Kline, Crystal F., Makara, Michael A., Little, Sean C., Higgins, John D., Hund, Thomas J., Band, Hamid, Mohler, Peter J.

“…Proper trafficking of membrane-bound ion channels and transporters is requisite for normal cardiac function. Endosome-based protein trafficking of…”
Get full text