Search Results - "Kline, C. Leah B."

Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism by Prabhu, Varun V, Madhukar, Neel S, Gilvary, Coryandar, Kline, C Leah B, Oster, Sophie, El-Deiry, Wafik S, Elemento, Olivier, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Tarapore, Rohinton S, Deacon, Sean, Charter, Neil, Jung, Jinkyu, Park, Deric M, Gilbert, Mark R, Rusert, Jessica, Wechsler-Reya, Robert, Arrillaga-Romany, Isabel, Batchelor, Tracy T, Wen, Patrick Y, Oster, Wolfgang, Allen, Joshua E

“…Dopamine receptor D2 (DRD2) is a G protein-coupled receptor antagonized by ONC201, an anticancer small molecule in clinical trials for high-grade gliomas and…”
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Discovery and clinical introduction of first-in-class imipridone ONC201 by Allen, Joshua E, Kline, C Leah B, Prabhu, Varun V, Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L, Pottorf, Richard S, Nallaganchu, B Rao, Olson, Gary L, Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T, Talekar, Mala K, Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L, Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S

“…ONC201 is the founding member of a novel class of anti-cancer compounds called imipridones that is currently in Phase II clinical trials in multiple advanced…”
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ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases by Kline, C Leah B, Van den Heuvel, A Pieter J, Allen, Joshua E, Prabhu, Varun V, Dicker, David T, El-Deiry, Wafik S

“…ONC201 (also called TIC10) is a small molecule that inactivates the cell proliferation- and cell survival-promoting kinases Akt and ERK and induces cell death…”
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Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies by Prabhu, Varun V, Talekar, Mala K, Lulla, Amriti R, Kline, C Leah B, Zhou, Lanlan, Hall, Junior, Van den Heuvel, A Pieter J, Dicker, David T, Babar, Jawad, Grupp, Stephan A, Garnett, Mathew J, McDermott, Ultan, Benes, Cyril H, Pu, Jeffrey J, Claxton, David F, Khan, Nadia, Oster, Wolfgang, Allen, Joshua E, El-Deiry, Wafik S

“…ONC201, founding member of the imipridone class of small molecules, is currently being evaluated in advancer cancer clinical trials. We explored single agent…”
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Correction: Discovery and clinical introduction of first-in-class imipridone ONC201 by Allen, Joshua E., Kline, C. Leah B., Prabhu, Varun V., Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L., Pottorf, Richard S., Nallaganchu, B. Rao, Olson, Gary L., Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T., Talekar, Mala K., Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L., Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S.

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Abstract A060: Targeting DRD2 dysregulation in recurrent glioblastoma with imipridone ONC201: predictive and pharmacodynamic clinical biomarker analyses by Prabhu, Varun Vijay, Madhukar, Neel, Kline, C. Leah B., Tarapore, Rohinton, El-Deiry, Wafik, Elemento, Olivier, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Zloza, Andrew, Benes, Cyril, Arrillaga, Isabel, Oster, Wolfgang, Allen, Joshua E.

“…Abstract Background: ONC201, an imipridone that is a selective antagonist of the G protein-coupled receptors dopamine receptor D2 (DRD2) and D3 (DRD3), has…”
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DRES-10. DRD5 IS A MODULATOR OF GLIOMA SUSCEPTIBILITY TO DRD2 ANTAGONISM BY ONC201 by Vijay Prabhu, Varun, Madhukar, Neel, Gilvary, Coryandar, Kline, C Leah B, Tarapore, Rohinton, El-Deiry, Wafik, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Benes, Cyril, Oster, Wolfgang, Elemento, Olivier, Allen, Joshua

“…Abstract ONC201 is the first selective antagonist of dopamine receptor D2 (DRD2) and D3 (DRD3) for clinical oncology that has exhibited preliminary clinical…”
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Abstract 3857: Selective targeting of dopamine receptor dysregulation in high grade gliomas with imipridone ONC201 by Prabhu, Varun Vijay, Madhukar, Neel, Kline, C. Leah B., Tarapore, Rohinton, El-Deiry, Wafik S., Rucker, Joseph, Doranz, Benjamin, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Benes, Cyril, Deacon, Sean, Charter, Neil, Free, R. Benjamin, Oster, Wolfgang, Sibley, David, Arrillaga, Isabel, Elemento, Olivier, Allen, Joshua E.

“…Abstract D2-like dopamine receptors (DRD2/3/4) are G protein-coupled receptors (GPCRs) that are overexpressed in glioblastoma (GBM) and their antagonism…”
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Single Agent and Synergistic Combinatorial Efficacy of First-in-Class Small Molecule Imipridone ONC201 in Hematological Malignancies In Vitro and In Vivo through Apoptosis Via the Integrated Stress Response Pathway by Prabhu, Varun Vijay, Talekar, Mala Kiran, Lulla, Amriti R, Kline, C. Leah B, Zhou, Lanlan, Hall, Junior, Van den Heuvel, A. Pieter J, Dicker, David T, Grupp, Stephan A, Garnett, Mathew, McDermott, Ultan, Benes, Cyril H, Pu, Jeffrey J, Claxton, David F, Oster, Wolfgang, Allen, Joshua E., El-Deiry, Wafik S.

“…▪ ONC201, founding member of the imipridone class of small molecules, is currently being evaluated in advancer cancer clinical trials. We explored single agent…”
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DDIS-08. THE SMALL MOLECULE IMIPRIDONE ONC201 IS ACTIVE IN GLIOBLASTOMA WITH DRD2 PATHWAY DYSREGULATION by Prabhu, Varun Vijay, Madhukar, Neel, Kline, C Leah B, Tarapore, Rohinton S, El-Deiry, Wafik, Elemento, Olivier, Rucker, Joseph, Doranz, Benjamin, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Benes, Cyril, Arrillaga-Romany, Isabel, Oster, Wolfgang, Allen, Joshua E

“…ONC201, an imipridone that is a selective antagonist of the G protein-coupled receptors dopamine receptor D2 (DRD2) and D3 (DRD3), has exhibited tumor…”
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Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies by Prabhu, Varun V., Talekar, Mala K., Lulla, Amriti R., Kline, C. Leah B., Zhou, Lanlan, Hall, Junior, Van den Heuvel, A. Pieter J., Dicker, David T., Babar, Jawad, Grupp, Stephan A., Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Pu, Jeffrey J., Claxton, David F., Khan, Nadia, Oster, Wolfgang, Allen, Joshua E., El-Deiry, Wafik S.

“…ONC201, founding member of the imipridone class of small molecules, is currently being evaluated in advancer cancer clinical trials. We explored single agent…”
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