Search Results - "Kline, B C"

Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism by Prabhu, Varun V, Madhukar, Neel S, Gilvary, Coryandar, Kline, C Leah B, Oster, Sophie, El-Deiry, Wafik S, Elemento, Olivier, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Tarapore, Rohinton S, Deacon, Sean, Charter, Neil, Jung, Jinkyu, Park, Deric M, Gilbert, Mark R, Rusert, Jessica, Wechsler-Reya, Robert, Arrillaga-Romany, Isabel, Batchelor, Tracy T, Wen, Patrick Y, Oster, Wolfgang, Allen, Joshua E

“…Dopamine receptor D2 (DRD2) is a G protein-coupled receptor antagonized by ONC201, an anticancer small molecule in clinical trials for high-grade gliomas and…”
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Molecular probes for diagnosis of fungal infections by SANDHU, G. S, KLINE, B. C, STOCKMAN, L, ROBERTS, G. D

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Discovery and clinical introduction of first-in-class imipridone ONC201 by Allen, Joshua E, Kline, C Leah B, Prabhu, Varun V, Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L, Pottorf, Richard S, Nallaganchu, B Rao, Olson, Gary L, Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T, Talekar, Mala K, Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L, Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S

“…ONC201 is the founding member of a novel class of anti-cancer compounds called imipridones that is currently in Phase II clinical trials in multiple advanced…”
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Assessment of invasion frequencies of cultured HEp-2 cells by clinical isolates of Helicobacter pylori using an acridine orange assay by Wilkinson, S M, Uhl, J R, Kline, B C, Cockerill, F R

“…AIMS: Recent studies suggest that Helicobacter pylori is an invasive enteropathogen. However, the efficiency with which this pathogen invades mammalian cells…”
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Determination of 16S rRNA Sequences of Enterococci and Application to Species Identification of Nonmotile Enterococcus gallinarum Isolates by PATEL, R, PIPER, K. E, ROUSE, M. S, STECKELBERG, J. M, UHL, J. R, KOHNER, P, HOPKINS, M. K, COCKERILL, F. R, KLINE, B. C

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ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases by Kline, C Leah B, Van den Heuvel, A Pieter J, Allen, Joshua E, Prabhu, Varun V, Dicker, David T, El-Deiry, Wafik S

“…ONC201 (also called TIC10) is a small molecule that inactivates the cell proliferation- and cell survival-promoting kinases Akt and ERK and induces cell death…”
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Molecular detection and identification of Paracoccidioides brasiliensis by SANDHU, G. S, ALEFF, R. A, KLINE, B. C, DA SILVA LACAZ, C

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Recombinant Mycobacterium tuberculosis KatG(S315T) Is a Competent Catalase-Peroxidase with Reduced Activity toward Isoniazid by Wengenack, Nancy L., Uhl, James R., St. Amand, Allison L., Tomlinson, Andy J., Benson, Linda M., Naylor, Stephen, Kline, Bruce C., Cockerill, Frank R., Rusnak, Frank

“…The presence of KatG(S315T), a mutation frequently detected in clinical isolates of Mycobacterium tuberculosis, has been associated with loss of…”
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Rapid Identification Of A Point Mutation Of The Mycobacterium tuberculosis Catalase-Peroxidase (katG) Gene Associated With Isoniazid Resistance by Cockerill, Frank R., Uhl, James R., Temesgen, Zelalem, Zhang, Ying, Stockman, Leslie, Roberts, Glenn D., Williams, Diana L., Kline, Bruce C.

“…The complete catalase-peroxidase (katG) gene DNA sequence was determined for 15 strains of Mycobacterium tuberculosis with a wide range of susceptibility to…”
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DNA Sequence Resembling vanA and vanB in the Vancomycin-Resistant Biopesticide Bacillus popilliae by Rippere, Karen, Patel, Robin, Uhl, James R., Piper, Kerryl E., Steckelberg, James M., Kline, Bruce C., Cockerill, Franklin R., Yousten, Allan A.

“…The origin of high-level vancomycin resistance in enterococci is unknown. Biopesticidal powders containing spores of Bacillus popilliae, which is…”
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Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies by Prabhu, Varun V, Talekar, Mala K, Lulla, Amriti R, Kline, C Leah B, Zhou, Lanlan, Hall, Junior, Van den Heuvel, A Pieter J, Dicker, David T, Babar, Jawad, Grupp, Stephan A, Garnett, Mathew J, McDermott, Ultan, Benes, Cyril H, Pu, Jeffrey J, Claxton, David F, Khan, Nadia, Oster, Wolfgang, Allen, Joshua E, El-Deiry, Wafik S

“…ONC201, founding member of the imipridone class of small molecules, is currently being evaluated in advancer cancer clinical trials. We explored single agent…”
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Dual asymmetric PCR: one-step construction of synthetic genes by Sandhu, G S, Aleff, R A, Kline, B C

“…We have developed a one-step process for constructing synthetic genes. Four adjacent oligonucleotides 17-100 bases in length having short overlaps of 15-17…”
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Control of the ccd operon in plasmid F by TAM, J. E, KLINE, B. C

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Correction: Discovery and clinical introduction of first-in-class imipridone ONC201 by Allen, Joshua E., Kline, C. Leah B., Prabhu, Varun V., Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L., Pottorf, Richard S., Nallaganchu, B. Rao, Olson, Gary L., Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T., Talekar, Mala K., Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L., Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S.

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In situ hybridization in paracoccidioidomycosis by DE BRITO, T, SANDHU, G. S, KLINE, B. C, ALEFF, R. A, SANDOVAL, M. P, SANTOS, R. T, BRANDAO, A. A. H, LACAZ, C. S

“…In situ hybridization (ISH) was performed using oral biopsies from patients with paracoccidioidomycosis and guinea pig testes inoculated with a culture of…”
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Chemiluminescent substrates increase sensitivity of antigen detection in western blots by Sandhu, G S, Eckloff, B W, Kline, B C

“…Replacement of colorimetric substrates in Western blots by chemiluminescent reagents enhances the sensitivity of detection by more than an order of magnitude…”
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A review of mini-F plasmid maintenance by Kline, B C

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Laboratory diagnosis of Pneumocystis carinii infections by PCR directed to genes encoding for mitochondrial 5S and 28S ribosomal RNA by Sandhu, GurpreetS, Kline, BruceC, Espy, MarkJ, Stockman, Leslie, Smith, ThomasF, Limper, AndrewH

“…PCR with 5S mitochondrial ribosomal RNA (5S) target is a sensitive and specific assay for the detection of Pneumocystis cariniiin clinical specimens from the…”
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Site-specific proteolysis of mini-F plasmid replication protein RepE destroys initiator function and generates an incompatibility substance by Kline, B C, Sandhu, G S, Eckloff, B W, Aleff, R A

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Rapid one-step characterization of recombinant vectors by direct analysis of transformed Escherichia coli colonies by Sandhu, G S, Precup, J W, Kline, B C

“…We have developed a polymerase chain reaction (PCR) based procedure for rapidly analyzing recombinant vectors in whole bacterial cells. No purification,…”
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