Search Results - "Kline, Allen D"

The effect of relaxation on the epitope mapping by saturation transfer difference NMR by Yan, Jiangli, Kline, Allen D., Mo, Huaping, Shapiro, Michael J., Zartler, Edward R.

“…The effect of longitudinal relaxation of ligand protons on saturation transfer difference (STD) was investigated by using a known binding system, dihydrofolate…”
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Complete Relative Stereochemistry of Multiple Stereocenters Using Only Residual Dipolar Couplings by Yan, Jiangli, Delaglio, Frank, Kaerner, Andreas, Kline, Allen D, Mo, Huaping, Shapiro, Michael J, Smitka, Tim A, Stephenson, Gregory A, Zartler, Edward R

“…Residual dipolar couplings (RDCs), in combination with molecular order matrix calculations, were used to unambiguously determine the complete relative…”
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A Novel Method for the Determination of Stereochemistry in Six-Membered Chairlike Rings Using Residual Dipolar Couplings by Yan, Jiangli, Kline, Allen D, Mo, Huaping, Shapiro, Michael J, Zartler, Edward R

“…A novel method for the determination of the relative stereochemistry of six-membered chairlike ring molecules by residual dipolar couplings is presented. C−H…”
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Monitoring the Ligand Binding Mode by Proton NMR Chemical Shift Differences by Subramaniam, Srisunder, Briggs, Stephen L., Kline, Allen D.

“…The ligand free–bound shift difference is established as a valuable binding mode monitor. Using bovine pancreatic trypsin, an indole inhibitor series and…”
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Epitope Mapping of Ligand−Receptor Interactions by Diffusion NMR by Yan, Jiangli, Kline, Allen D, Mo, Huaping, Zartler, Edward R, Shapiro, Michael J

“…A novel method based on diffusion NMR for the epitope mapping of ligand binding is presented. The intermolecular NOE builds up during a long diffusion period…”
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RAMPED-UP NMR:  Multiplexed NMR-Based Screening for Drug Discovery by Zartler, Edward R, Hanson, Jeffrey, Jones, Bryan E, Kline, Allen D, Martin, George, Mo, Huaping, Shapiro, Michael J, Wang, Rong, Wu, Haiping, Yan, Jiangli

“…The crucial step in drug discovery is the identification of a lead compound from a vast chemical library by any number of screening techniques. NMR-based…”
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ID NMR Methods in ligand-receptor interactions by Zartler, Edward R, Yan, Jiangli, Mo, Huaping, Kline, Allen D, Shapiro, Michael J

“…The drug discovery process often involves the screening of compound libraries to identify drug candidates capable of binding to target macromolecules. New…”
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High resolution MRI reveals reduced hippocampal volume in apoE4 targeted replacement mice by Hunter, Jesse M, Cockman, Michael D, Kline, Allen D, Surridge, Scott, Rothstein, Emily C, Liu, Hong, Zhu, Mingming, Shannon, Harlan, Trowbridge, Melissa, Peterson, Daniel A, Peterson, Letia D, Sullivan, Patrick M, Krishnamurthy, Krish, Hutton, Micheal L, Paul, Steven M

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Amide proton exchange in the .alpha.-amylase polypeptide inhibitor Tendamistat studied by two-dimensional proton nuclear magnetic resonance by Wang, Qiwen, Kline, Allen D, Wuethrich, Kurt

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The absolute sign of J coupling constants determined using the order matrix calculation by Yan, Jiangli, Kline, Allen D., Mo, Huaping, Shapiro, Michael J., Zartler, Edward R.

“…A novel methodology using the order matrix calculation to determine the absolute sign of spin–spin couplings based on the structure of organic compounds is…”
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Leptin is a four-helix bundle: secondary structure by NMR by Kline, Allen D, Becker, Gerald W, Churgay, Lisa M, Landen, Bryan E, Martin, Debra K, Muth, William L, Rathnachalam, Radhakrishnan, Richardson, John M, Schoner, Brigitte, Ulmer, Maverick, Hale, John E

“…Leptin is a signaling protein that in its mutant forms has been associated with obesity and Type II diabetes. The lack of sequence similarity has precluded…”
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Non-Peptide RGD Surrogates Which Mimic a Gly-Asp β-Turn:  Potent Antagonists of Platelet Glycoprotein IIb−IIIa by Fisher, Matthew J, Gunn, Bruce, Harms, Cathy S, Kline, Allen D, Mullaney, Jeffrey T, Nunes, Anne, Scarborough, Robert M, Arfsten, Ann E, Skelton, Marshall A, Um, Suzane L, Utterback, Barbara G, Jakubowski, Joseph A

“…Cyclic heptapeptide 1, which contains an Arg-Gly-Asp sequence, has good affinity for the platelet receptor GPIIb−IIIa and was chosen for study by 1H NMR…”
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Conformation of A82846B, a glycopeptide antibiotic, complexed with its cell wall fragment: An asymmetric homodimer determined using NMR spectroscopy by Prowse, Will G, Kline, Allen D, Skelton, Marshall A, Loncharich, Richard J

“…Proton NMR assignments were determined for the asymmetric dimer complex of A82846B with the pentapeptide cell-wall fragment. A total of 683 experimental…”
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Complete sequence-specific proton NMR assignments for human insulin by Kline, Allen D, Justice, Richard M

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P2‐352: High resolution MRI reveals reduced hippocampal volume in apoE4 targeted replacement mice by Hunter, Jesse M., Cockman, Michael D., Kline, Allen D., Surridge, Scott, Rothstein, Emily C., Liu, Hong, Zhu, Mingming, Shannon, Harlan, Trowbridge, Melissa, Peterson, Daniel A., Peterson, Letia D., Sullivan, Patrick M., Krishnamurthy, Krish, Hutton, Micheal L., Paul, Steven M.

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Determination of the complete three-dimensional structure of the alpha-amylase inhibitor tendamistat in aqueous solution by nuclear magnetic resonance and distance geometry by Kline, A D, Braun, W, Wüthrich, K

“…The complete three-dimensional structure of the alpha-amylase inhibitor Tendamistat in aqueous solution was determined by 1H nuclear magnetic resonance and…”
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Complete sequence-specific H NMR assignments for human insulin by KLINE, A. D, JUSTICE, R. M

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Comparison of the high-resolution structures of the alpha-amylase inhibitor tendamistat determined by nuclear magnetic resonance in solution and by X-ray diffraction in single crystals by Billeter, M, Kline, A D, Braun, W, Huber, R, Wüthrich, K

“…The three-dimensional structure of the alpha-amylase inhibitor Tendamistat determined by nuclear magnetic resonance in aqueous solution is compared with the…”
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Glutamine-derived aldehydes for the inhibition of human rhinovirus 3C protease by Kaldor, Stephen W., Hammond, Marlys, Dressman, Bruce A., Labus, Jean M., Chadwell, Frederick W., Kline, Allen D., Heinz, Beverly A.

“…Peptide aldehydes have been synthesized and evaluated as inhibitors of human rhinovirus 3C protease. Those inhibitors containing a C-terminal glutamine…”
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Dihydroisoquinolone RGD mimics. Exploration of the aspartate isostere by Fisher, Matthew J., Gunn, Bruce P., Harms, Cathy S., Kline, Allen D., Mullaney, Jeffrey T., Scarborough, Robert M., Skelton, Marshall A., Um, Suzane L., Utterback, Barbara G., Jakubowski, Joseph A.

“…Disubstituted 3,4-dihydroisoquinolones that contain an ether-linked benzamidine at C 6 and a β-substituted aspartate mimic at C 2 offer enhanced affinity for…”
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