Search Results - "Klimyuk, Victor"

Viral vectors for the expression of proteins in plants by Gleba, Yuri, Klimyuk, Victor, Marillonnet, Sylvestre

“…The use of plant viral vectors for the transient expression of heterologous proteins offers a useful tool for the large-scale production of proteins of…”
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Systemic Agrobacterium tumefaciens-mediated transfection of viral replicons for efficient transient expression in plants by Marillonnet, S, Thoeringer, C, Kandzia, R, Klimyuk, V, Gleba, Y

“…Plant biotechnology relies on two approaches for delivery and expression of heterologous genes in plants: stable genetic transformation and transient…”
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Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting viral vectors by Giritch, A, Marillonnet, S, Engler, C, Eldik, G. van, Botterman, J, Klimyuk, V, Gleba, Y

“…Plant viral vectors allow expression of heterologous proteins at high yields, but so far, they have been unable to express heterooligomeric proteins…”
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A randomized, double-blind, placebo-controlled, dose-escalating phase I trial to evaluate safety and immunogenicity of a plant-produced, bivalent, recombinant norovirus-like particle vaccine by Leroux-Roels, Isabel, Maes, Cathy, Joye, Jasper, Jacobs, Bart, Jarczowski, Franziska, Diessner, André, Janssens, Yorick, Waerlop, Gwenn, Tamminen, Kirsi, Heinimäki, Suvi, Blazevic, Vesna, Leroux-Roels, Geert, Klimyuk, Victor, Adachi, Hiroshi, Hiruta, Kazuyuki, Thieme, Frank

“…Noroviruses (NoV) are the leading cause of epidemic acute gastroenteritis in humans worldwide and a safe and effective vaccine is needed. Here, a phase I,…”
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Production of recombinant antigens and antibodies in Nicotiana benthamiana using 'magnifection' technology: GMP-compliant facilities for small- and large-scale manufacturing by Klimyuk, Victor, Pogue, Gregory, Herz, Stefan, Butler, John, Haydon, Hugh

“…This review describes the adaptation of the plant virus-based transient expression system, magnICON(®) for the at-scale manufacturing of pharmaceutical…”
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Immune responses in healthy adults elicited by a bivalent norovirus vaccine candidate composed of GI.4 and GII.4 VLPs without adjuvant by Waerlop, Gwenn, Janssens, Yorick, Jacobs, Bart, Jarczowski, Franziska, Diessner, André, Leroux-Roels, Geert, Klimyuk, Victor, Leroux-Roels, Isabel, Thieme, Frank

“…The development of an efficacious vaccine against norovirus is of paramount importance given its potential to reduce the global burden of norovirus-associated…”
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Immunoabsorbent Nanoparticles Based on a Tobamovirus Displaying Protein A by Werner, Stefan, Marillonnet, Sylvestre, Hause, Gerd, Klimyuk, Victor, Gleba, Yuri

“…Earlier attempts to express peptides longer than 20 aa on the surface of tobamoviruses such as tobacco mosaic virus have failed. Surprisingly, we found that a…”
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In planta Engineering of Viral RNA Replicons: Efficient Assembly by Recombination of DNA Modules Delivered by Agrobacterium by Marillonnet, Sylvestre, Giritch, Anatoli, Gils, Mario, Kandzia, Romy, Klimyuk, Victor, Gleba, Yuri, Zenk, Meinhart H.

“…We have developed an efficient, versatile, and user-friendly viral engineering and expression system that is based on in planta assembly of functional viral…”
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Immunization with Plant-Expressed Hemagglutinin Protects Chickens from Lethal Highly Pathogenic Avian Influenza Virus H5N1 Challenge Infection by KALTHOFF, Donata, GIRITCH, Anatoli, GEISLER, Katharina, BETTMANN, Ulrike, KLIMYUK, Victor, HEHNEN, Hans-Robert, GLEBA, Yuri, BEER, Martin

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Engineering viral expression vectors for plants: the ‘full virus’ and the ‘deconstructed virus’ strategies by Gleba, Yuri, Marillonnet, Sylvestre, Klimyuk, Victor

“…Plant viral vectors are being successfully developed and exploited for the industrial-scale expression of heterologous proteins and as a research tool for…”
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CD28 Aptamers as Powerful Immune Response Modulators by Pastor, Fernando, Soldevilla, Mario M, Villanueva, Helena, Kolonias, Despina, Inoges, Susana, de Cerio, Ascensión L, Kandzia, Romy, Klimyuk, Victor, Gleba, Yuri, Gilboa, Eli, Bendandi, Maurizio

“…CD28 is one of the main costimulatory receptors responsible for the proper activation of T lymphocytes. We have isolated two aptamers that bind to the CD28…”
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Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system by Santi, L, Giritch, A, Roy, C.J, Marillonnet, S, Klimyuk, V, Gleba, Y, Webb, R, Arntzen, C.J, Mason, H.S

“…Plague is still an endemic disease in different regions of the world. Increasing reports of incidence, the discovery of antibiotic resistance strains, and…”
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A novel function for a ubiquitous plant enzyme pectin methylesterase: The enhancer of RNA silencing by Dorokhov, Yuri L., Frolova, Olga Y., Skurat, Eugene V., Ivanov, Peter A., Gasanova, Tatjana V., Sheveleva, Anna A., Ravin, Nikolay V., Mäkinen, Kristiina M., Klimyuk, Victor I., Skryabin, Konstantin G., Gleba, Yuri Y., Atabekov, Joseph G.

“…Co-agroinjection of Nicotiana benthamiana leaves with the pectin methylesterase (proPME) gene and the TMV:GFP vector resulted in a stimulation of virus-induced…”
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A novel signal recognition particle targets light-harvesting proteins to the thylakoid membranes by Schuenemann, D. (Carnegie Institution of Washington, Stanford, CA.), Gupta, S, Persello-Cartieaux, F, Klimyuk, V.I, Jones, J.D.G, Nussaume, L, Hoffman, N.E

“…The mechanisms involved in the posttranslational targeting of membrane proteins are not well understood. The light-harvesting chlorophyll proteins (LHCP) of…”
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A Chromodomain Protein Encoded by the Arabidopsis CAO Gene Is a Plant-Specific Component of the Chloroplast Signal Recognition Particle Pathway That Is Involved in LHCP Targeting by Klimyuk, Victor I., Persello-Cartieaux, Fabienne, Havaux, Michel, Contard-David, Pascale, Schuenemann, Danja, Meiherhoff, Karin, Gouet, Patrice, Jonathan D. G. Jones, Hoffman, Neil E., Nussaume, Laurent

“…A recessive mutation in Arabidopsis, named chaos (for chlorophyll a/b binding protein harvesting-organelle specific; designated gene symbol CAO), was isolated…”
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Function Search in a Large Transcription Factor Gene Family in Arabidopsis: Assessing the Potential of Reverse Genetics to Identify Insertional Mutations in R2R3 MYB Genes by Meissner, Ruth C., Jin, Hailing, Cominelli, Eleonora, Denekamp, Marten, Fuertes, Antonio, Greco, Raffaella, Kranz, Harald D., Penfield, Steven, Petroni, Katia, Urzainqui, Ana, Martin, Cathie, Paz-Ares, Javier, Smeekens, Sjef, Tonelli, Chiara, Weisshaar, Bernd, Baumann, Elvira, Klimyuk, Victor, Marillonnet, Sylvestre, Patel, Kanu, Speulman, Elly, Tissier, Alain F., Bouchez, David, Jonathan J. D. Jones, Pereira, Andy, Wisman, Ellen, Bevan, Michael

“…More than 92 genes encoding MYB transcription factors of the R2R3 class have been described in Arabidopsis. The functions of a few members of this large gene…”
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AtDMC1, the Arabidopsis homologue of the yeast DMC1 gene: characterization, transposon‐induced allelic variation and meiosis‐associated expression by Klimyuk, Victor I., Jones, Jonathan D.G.

“…Based on homologies between the yeast DMC1 and the lily LIM15 meiosis‐specific genes, degenerate PCR primers were designed that amplified the Arabidopsis DMC1…”
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The structure of the rat vitamin B12 transporter TC and its complex with glutathionylcobalamin by Bokhove, Marcel, Kawamura, Takashi, Okumura, Hideo, Goto, Sawako, Kawano, Yoshiaki, Werner, Stefan, Jarczowski, Franziska, Klimyuk, Victor, Saito, Akihiko, Kumasaka, Takashi

“…Vitamin B12 (cobalamin or Cbl) functions as a cofactor in two important enzymatic processes in human cells, and life is not sustainable without it. B12 is…”
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Safety and immunogenicity studies in animal models support clinical development of a bivalent norovirus-like particle vaccine produced in plants by Tusé, Daniel, Malm, Maria, Tamminen, Kirsi, Diessner, André, Thieme, Frank, Jarczowski, Franziska, Blazevic, Vesna, Klimyuk, Victor

“…•Noroviruses (NoV) are the leading cause of epidemic acute gastroenteritis in humans.•There is currently no safe and effective preventative NoV vaccine on the…”
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Alkali treatment for rapid preparation of plant material for reliable PCR analysis by Klimyuk, Victor I., Carroll, Bernard J., Thomas, Colwyn M., Jones, Jonathan D.G.

“…Summary For plant genetics, it would be useful to monitor easily the segregation of different alleles using the polymerase chain reaction (PCR). Preparation of…”
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