Search Results - "Klimek, Bogna"
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Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
Published in Nature communications (12-02-2021)“…Self-reactive CD8 + T cells are important mediators of progressive tissue damage in autoimmune diseases, but the molecular program underlying these cells’…”
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Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
Published in Cell (04-10-2018)“…Inflammatory disorders of the CNS are frequently accompanied by synaptic loss, which is thought to involve phagocytic microglia and complement components…”
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Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells
Published in Immunity (Cambridge, Mass.) (15-05-2018)“…Infections are thought to trigger CD8+ cytotoxic T lymphocyte (CTL) responses during autoimmunity. However, the transcriptional programs governing the…”
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Cold exposure protects from neuroinflammation through immunologic reprogramming
Published in Cell metabolism (02-11-2021)“…Autoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immune-mediated diseases is unclear. Ly6Chi monocytes are…”
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Tissue-resident memory CD8 + T cells cooperate with CD4 + T cells to drive compartmentalized immunopathology in the CNS
Published in Science translational medicine (13-04-2022)“…In chronic inflammatory diseases of the central nervous system (CNS), immune cells persisting behind the blood-brain barrier are supposed to promulgate local…”
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Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity
Published in Genes and immunity (01-09-2022)“…Adaptive immune repertoires are composed by the ensemble of B and T-cell receptors within an individual, reflecting both past and current immune responses…”
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Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells
Published in Immunity (Cambridge, Mass.) (19-03-2019)Get full text
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