Search Results - "Klima, Jason C"

De novo design of tunable, pH-driven conformational changes by Boyken, Scott E, Benhaim, Mark A, Busch, Florian, Jia, Mengxuan, Bick, Matthew J, Choi, Heejun, Klima, Jason C, Chen, Zibo, Walkey, Carl, Mileant, Alexander, Sahasrabuddhe, Aniruddha, Wei, Kathy Y, Hodge, Edgar A, Byron, Sarah, Quijano-Rubio, Alfredo, Sankaran, Banumathi, King, Neil P, Lippincott-Schwartz, Jennifer, Wysocki, Vicki H, Lee, Kelly K, Baker, David

“…The ability of naturally occurring proteins to change conformation in response to environmental changes is critical to biological function. Although there have…”
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De novo design of immunoglobulin-like domains by Chidyausiku, Tamuka M., Mendes, Soraia R., Klima, Jason C., Nadal, Marta, Eckhard, Ulrich, Roel-Touris, Jorge, Houliston, Scott, Guevara, Tibisay, Haddox, Hugh K., Moyer, Adam, Arrowsmith, Cheryl H., Gomis-Rüth, F. Xavier, Baker, David, Marcos, Enrique

“…Antibodies, and antibody derivatives such as nanobodies, contain immunoglobulin-like (Ig) β-sandwich scaffolds which anchor the hypervariable antigen-binding…”
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Incorporation of sensing modalities into de novo designed fluorescence-activating proteins by Klima, Jason C., Doyle, Lindsey A., Lee, Justin Daho, Rappleye, Michael, Gagnon, Lauren A., Lee, Min Yen, Barros, Emilia P., Vorobieva, Anastassia A., Dou, Jiayi, Bremner, Samantha, Quon, Jacob S., Chow, Cameron M., Carter, Lauren, Mack, David L., Amaro, Rommie E., Vaughan, Joshua C., Berndt, Andre, Stoddard, Barry L., Baker, David

“…Through the efforts of many groups, a wide range of fluorescent protein reporters and sensors based on green fluorescent protein and its relatives have been…”
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Inhibition of a malaria host–pathogen interaction by a computationally designed inhibitor by Tobin, Autumn R., Crow, Rachel, Urusova, Darya V., Klima, Jason C., Tolia, Niraj H., Strauch, Eva‐Maria

“…Malaria is a substantial global health burden with 229 million cases in 2019 and 450,000 deaths annually. Plasmodium vivax is the most widespread…”
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Pharmacological investigation of the bioluminescence signaling pathway of the dinoflagellate Lingulodinium polyedrum: evidence for the role of stretch-activated ion channels by Jin, Kelly, Klima, Jason C., Deane, Grant, Dale Stokes, Malcolm, Latz, Michael I.

“…Dinoflagellate bioluminescence serves as a whole‐cell reporter of mechanical stress, which activates a signaling pathway that appears to involve the opening of…”
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Design of De Novo Mini Fluorescence Activating Proteins as pH and Calcium Biosensors by Klima, Jason C

“…Recent advances in de novo protein design have enabled the design of mini fluorescence activating proteins (mFAPs): mini β-barrel topologies that bind and…”
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