Search Results - "Klika, Karel D"

Applications of fluorine-containing amino acids for drug design by Mei, Haibo, Han, Jianlin, Klika, Karel D., Izawa, Kunisuke, Sato, Tatsunori, Meanwell, Nicholas A., Soloshonok, Vadim A.

“…Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to two general trends in the modern pharmaceutical industry. Firstly, the…”
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The self-disproportionation of enantiomers (SDE): a menace or an opportunity? by Han, Jianlin, Kitagawa, Osamu, Wzorek, Alicja, Klika, Karel D, Soloshonok, Vadim A

“…Herein we report on the well-documented, yet not widely known, phenomenon of the self-disproportionation of enantiomers (SDE): the spontaneous fractionation of…”
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Linker Modification Strategies To Control the Prostate-Specific Membrane Antigen (PSMA)-Targeting and Pharmacokinetic Properties of DOTA-Conjugated PSMA Inhibitors by Benešová, Martina, Bauder-Wüst, Ulrike, Schäfer, Martin, Klika, Karel D, Mier, Walter, Haberkorn, Uwe, Kopka, Klaus, Eder, Matthias

“…Since prostate-specific membrane antigen (PSMA) is up-regulated in nearly all stages of prostate cancer (PCa), PSMA can be considered as a viable diagnostic…”
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Recommended Tests for the Self-Disproportionation of Enantiomers (SDE) to Ensure Accurate Reporting of the Stereochemical Outcome of Enantioselective Reactions by Han, Jianlin, Wzorek, Alicja, Klika, Karel D., Soloshonok, Vadim A.

“…The purpose of this review is to highlight the necessity of conducting tests to gauge the magnitude of the self-disproportionation of enantiomers (SDE)…”
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A Call for a Change in Policy Regarding the Necessity for SDE Tests to Validate the Veracity of the Outcome of Enantioselective Syntheses, the Inherent Chiral State of Natural Products, and Other Cases Involving Enantioenriched Samples by Han, Jianlin, Dembinski, Roman, Soloshonok, Vadim A., Klika, Karel D.

“…We wish to draw attention to an important issue concerning scientific practice with regard to enhancing the quality of publications in Molecules (as well as…”
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The self‐disproportionation of enantiomers (SDE): The effect of scaling down, potential problems versus prospective applications, possible new occurrences, and unrealized opportunities? by Han, Jianlin, Wzorek, Alicja, Soloshonok, Vadim A., Klika, Karel D.

“…This commentary discusses an important, though not widely appreciated, chiral phenomenon of molecular chirality that effectively always occurs whenever…”
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Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy? by Kvacskay, Peter, Yao, Nina, Schnotz, Jürgen-Heinz, Scarpone, Roberta, Carvalho, Rui de Albuquerque, Klika, Karel D, Merkt, Wolfgang, Tretter, Theresa, Lorenz, Hanns-Martin, Tykocinski, Lars-Oliver

“…A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T…”
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Terminology Related to the Phenomenon 'Self-Disproportionation of Enantiomers' (SDE) by Soloshonok, Vadim A., Klika, Karel D.

“…Terms related to the phenomenon self‐disproportion of enantiomers (SDE) are discussed, particularly with respect to recently suggested alternative terms. Of…”
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Synthesis, Characterization and Biological Investigations of Half-Sandwich Ruthenium(II) Complexes Containing Benzimidazole Moiety by Rogala, Patrycja, Jabłońska-Wawrzycka, Agnieszka, Czerwonka, Grzegorz, Kazimierczuk, Katarzyna, Gałczyńska, Katarzyna, Michałkiewicz, Sławomir, Kalinowska-Tłuścik, Justyna, Karpiel, Marta, Klika, Karel D

“…Half-sandwich Ru(II) complexes belong to group of biologically active metallo-compounds with promising antimicrobial and anticancer activity. Herein, we report…”
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Multifunctional Polymer/Porous Boron Nitride Nanosheet Membranes for Superior Trapping Emulsified Oils and Organic Molecules by Liu, Dan, He, Li, Lei, Weiwei, Klika, Karel D., Kong, Lingxue, Chen, Ying

“…Effective oil/water separation and removal of organic molecules from water are of worldwide importance for water source protection. Multifunctional sorbent…”
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Anticancer potential of rhizome extract and a labdane diterpenoid from Curcuma mutabilis plant endemic to Western Ghats of India by Soumya, T., Lakshmipriya, T., Klika, Karel D., Jayasree, P. R., Manish Kumar, P. R.

“…Zingiberaceae plants are well known for their use in ethnomedicine. Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from…”
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Glyoxal in hyperglycaemic ischemic stroke - a cohort study by Rhein, Sina, Inderhees, Julica, Herrmann, Oliver, Othman, Alaa, Begemann, Kimberly, Fleming, Thomas, Nawroth, Peter P, Klika, Karel D, Isa, Rakad, König, Inke R, Royl, Georg, Schwaninger, Markus

“…Hyperglycaemia is frequent in acute ischemic stroke and denotes a bad prognosis, even in the absence of pre-existing diabetes. However, in clinical trials…”
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Signature of protein unfolding in chemical exchange saturation transfer imaging by Goerke, Steffen, Zaiss, Moritz, Kunz, Patrick, Klika, Karel D., Windschuh, Johannes D., Mogk, Axel, Bukau, Bernd, Ladd, Mark E., Bachert, Peter

“…Chemical exchange saturation transfer (CEST) allows the detection of metabolites of low concentration in tissue with nearly the sensitivity of MRI with water…”
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The self-disproportionation of the enantiomers (SDE) of methyl n-pentyl sulfoxide via achiral, gravity-driven column chromatography: a case study by Wzorek, Alicja, Klika, Karel D, Drabowicz, Józef, Sato, Azusa, Aceña, José Luis, Soloshonok, Vadim A

“…This work explores the self-disproportionation of enantiomers (SDE) of chiral sulfoxides via achiral, gravity-driven column chromatography using methyl…”
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Structure-based design, and development of amidinyl, amidoximyl and hydroxamic acid based organic molecules as novel antimalarial drug candidates by Adebayo, Glory P, Oduselu, Gbolahan O, Aderohunmu, Damilola V, Klika, Karel D, Olasehinde, Grace I, Ajani, Olayinka O, Adebiyi, Ezekiel

“…Malaria remains a significant global health concern causing numerous fatalities and the emergence of antimalarial drug resistance highlights the urgent need…”
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Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal by Weigand, Tim, Singler, Benjamin, Fleming, Thomas, Nawroth, Peter, Klika, Karel D., Thiel, Christian, Baelde, Hans, Garbade, Sven F., Wagner, Andreas H., Hecker, Markus, Yard, Benito A., Amberger, Albert, Zschocke, Johannes, Schmitt, Claus P., Peters, Verena

“…Background/Aims: Reactive dicarbonyl compounds, such as methylglyoxal (MG), contribute to diabetic complications. MG-scavenging capacities of carnosine and…”
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The Self-Disproportionation of Enantiomers (SDE) of α-Pinene via Evaporation off Silica Gel and Foam Fractionation—Validation of the Plausibility of SDE via Gas Chromatography (GC) for α-Pinene by Wzorek, Alicja, Soloshonok, Vadim A., Klika, Karel D.

“…α-Pinene is an intriguing monoterpene as it has been reported to undergo the self-disproportionation of enantiomers (SDE) phenomenon via gas chromatography…”
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Riproximin Exhibits Diversity in Sugar Binding, and Modulates some Metastasis-Related Proteins with Lectin like Properties in Pancreatic Ductal Adenocarcinoma by Sagini, Micah N, Klika, Karel D, Orry, Andrew, Zepp, Michael, Mutiso, Joshua, Berger, Martin R

“…Riproximin (Rpx) is a type II ribosome-inactivating protein with specific anti-proliferative activity. It was purified from Ximenia by affinity chromatography…”
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Enantiomeric Enrichments via the Self-Disproportionation of Enantiomers (SDE) by Achiral, Gravity-Driven Column Chromatography: a Case Study Using N-(1-Phenylethyl)acetamide for Optimizing the Enantiomerically Pure Yield and Magnitude of the SDE by Wzorek, Alicja, Sato, Azusa, Drabowicz, Józef, Soloshonok, Vadim A., Klika, Karel D.

“…This work explores the self‐disproportionation of enantiomers (SDE) via achiral, gravity‐driven column chromatography as typically used in laboratory settings…”
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Flurbiprofen: A Study of the Behavior of the Scalemate by Chromatography, Sublimation, and NMR by Kwiatkowska, Magdalena, Wzorek, Alicja, Kolbus, Anna, Urbaniak, Mariusz, Han, Jianlin, Soloshonok, Vadim A., Klika, Karel D.

“…2-(2-Fluoro-4-biphenyl) propionic acid (flurbiprofen), from the phenylalkanoic acid family of nonsteroidal anti-inflammatory drugs (NSAID’s), is currently on…”
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