Search Results - "Klijn, Jan G"

Long-Term Risk of Cardiovascular Disease in 10-Year Survivors of Breast Cancer by Hooning, Maartje J., Botma, Akke, Aleman, Berthe M. P., Baaijens, Margreet H. A., Bartelink, Harry, Klijn, Jan G. M., Taylor, Carolyn W., van Leeuwen, Flora E.

“…Background Radiotherapy for breast cancer as delivered in the 1970s has been associated with increased risk of cardiovascular disease, but recent studies of…”
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Strong Time Dependence of the 76-Gene Prognostic Signature for Node-Negative Breast Cancer Patients in the TRANSBIG Multicenter Independent Validation Series by DESMEDT, Christine, PIETTE, Fanny, BERGH, Jonas, LIDEREAU, Rosette, ELLIS, Paul, HARRIS, Adrian L, KLIJN, Jan G. M, FOEKENS, John A, CARDOSO, Fatima, PICCART, Martine J, BUYSE, Marc, SOTIRIOU, Christos, LOI, Sherene, YIXIN WANG, LALLEMAND, Frangoise, HAIBE-KAINS, Benjamin, VIALE, Giuseppe, DELORENZI, Mauro, YI ZHANG, SAGHATCHIAN D'ASSIGNIES, Mahasti

“…Purpose: Recently, a 76-gene prognostic signature able to predict distant metastases in lymph node–negative (N − ) breast cancer patients was reported. The…”
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Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer by Foekens, John A, Sieuwerts, Anieta M, Smid, Marcel, Look, Maxime P, de Weerd, Vanja, Boersma, Antonius W.M, Klijn, Jan G.M, Wiemer, Erik A.C, Martens, John W.M

“…In this study, we quantified 249 mature micro-RNA (miRNA) transcripts in estrogen receptor-positive (ER⁺) primary breast tumors of patients with lymph…”
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Definition of Clinically Distinct Molecular Subtypes in Estrogen Receptor–Positive Breast Carcinomas Through Genomic Grade by LOI, Sherene, HAIBE-KAINS, Benjamin, KLIJN, Jan G. M, LARSIMONT, Denis, BUYSE, Marc, BONTEMPI, Gianluca, DELORENZI, Mauro, PICCART, Martine J, SOTIRIOU, Christos, DESMEDT, Christine, LALLEMAND, Francoise, TUTT, Andrew M, GILLET, Cheryl, ELLIS, Paul, HARRIS, Adrian, BERGH, Jonas, FOEKENS, John A

“…A number of microarray studies have reported distinct molecular profiles of breast cancers (BC), such as basal-like, ErbB2-like, and two to three luminal-like…”
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Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer by Hollestelle, Antoinette, Peeters, Justine K., Smid, Marcel, Timmermans, Mieke, Verhoog, Leon C., Westenend, Pieter J., Heine, Anouk A. J., Chan, Alan, Sieuwerts, Anieta M., Wiemer, Erik A. C., Klijn, Jan G. M., van der Spek, Peter J., Foekens, John A., Schutte, Mieke, den Bakker, Michael A., Martens, John W. M.

“…Epithelial to mesenchymal transition (EMT) is typically defined by the acquisition of a spindle cell morphology in combination with loss of E-cadherin and…”
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Genes Associated With Breast Cancer Metastatic to Bone by SMID, Marcel, YIXIN WANG, KLIJN, Jan G. M, SIEUWERTS, Anieta M, YI ZHANG, ATKINS, David, MARTENS, John W. M, FOEKENS, John A

“…The biology of tumors relapsing to bone is poorly understood. In this study, we initiated a search for genes that are implicated in tumors relapsing to bone in…”
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DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients by Nimmrich, Inko, Sieuwerts, Anieta M., Meijer-van Gelder, Marion E., Schwope, Ina, Bolt-de Vries, Joan, Harbeck, Nadia, Koenig, Thomas, Hartmann, Oliver, Kluth, Antje, Dietrich, Dimo, Magdolen, Viktor, Portengen, Henk, Look, Maxime P., Klijn, Jan G. M., Lesche, Ralf, Schmitt, Manfred, Maier, Sabine, Foekens, John A., Martens, John W. M.

“…Background In this study, we evaluated if PITX2 DNA methylation is a marker for disease recurrence in lymph node-negative (LNN), steroid hormone…”
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Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes by Riaz, Muhammad, Berns, Els M. J. J., Sieuwerts, Anieta M., Ruigrok-Ritstier, Kirsten, de Weerd, Vanja, Groenewoud, Arwin, Uitterlinden, Andrè G., Look, Maxime P., Klijn, Jan G. M., Sleijfer, Stefan, Foekens, John A., Martens, John W. M.

“…To understand the biology of low-risk breast cancer alleles, and to investigate whether these loci also contribute to disease progression that was once…”
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Prophylactic mastectomy in BRCA1/2 mutation carriers and women at risk of hereditary breast cancer: long-term experiences at the Rotterdam Family Cancer Clinic by Heemskerk-Gerritsen, Bernadette A M, Brekelmans, Cecile T M, Menke-Pluymers, Marian B E, van Geel, Albert N, Tilanus-Linthorst, Madeleine M A, Bartels, Carina C M, Tan, Murly, Meijers-Heijboer, Hanne E J, Klijn, Jan G M, Seynaeve, Caroline

“…BRCA1/2 mutation carriers and women from a hereditary breast(/ovarian) cancer family have a highly increased risk of developing breast cancer (BC)…”
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Assessment of false-negative cases of breast MR imaging in women with a familial or genetic predisposition by Obdeijn, Inge-Marie A, Loo, Claudette E, Rijnsburger, Adriana J, Wasser, Martin N. J. M, Bergers, Elisabeth, Kok, Theo, Klijn, Jan G. M, Boetes, Carla

“…In order to assess the characteristics of malignant breast lesions those were not detected during screening by MR imaging. In the Dutch MRI screening study…”
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Copy Number Alterations that Predict Metastatic Capability of Human Breast Cancer by YI ZHANG, MARTENS, John W. M, YU, Jack X, JIANG, John, SIEUWERTS, Anieta M, SMID, Marcel, KLIJN, Jan G. M, YIXIN WANG, FOEKENS, John A

“…We have analyzed the DNA copy numbers for over 100,000 single-nucleotide polymorphism loci across the human genome in genomic DNA from 313 lymph node-negative…”
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Efficacy of MRI and Mammography for Breast-Cancer Screening in Women with a Familial or Genetic Predisposition by Kriege, Mieke, Brekelmans, Cecile T.M, Boetes, Carla, Besnard, Peter E, Zonderland, Harmine M, Obdeijn, Inge Marie, Manoliu, Radu A, Kok, Theo, Peterse, Hans, Tilanus-Linthorst, Madeleine M.A, Muller, Sara H, Meijer, Sybren, Oosterwijk, Jan C, Beex, Louk V.A.M, Tollenaar, Rob A.E.M, de Koning, Harry J, Rutgers, Emiel J.T, Klijn, Jan G.M

“…In a comparison of mammography with magnetic resonance imaging (MRI) for screening women at high risk for breast cancer, MRI was more sensitive but less…”
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Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer by Yu, Jack X, Sieuwerts, Anieta M, Zhang, Yi, Martens, John W M, Smid, Marcel, Klijn, Jan G M, Wang, Yixin, Foekens, John A

“…Published prognostic gene signatures in breast cancer have few genes in common. Here we provide a rationale for this observation by studying the prognostic…”
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BRCA1 Mutation and Young Age Predict Fast Breast Cancer Growth in the Dutch, United Kingdom, and Canadian Magnetic Resonance Imaging Screening Trials by Tilanus-Linthorst, Madeleine M A, Obdeijn, Inge-Marie, Hop, Wim C J, Causer, Petrina A, Leach, Martin O, Warner, Ellen, Pointon, Linda, Hill, Kimberley, Klijn, Jan G M, Warren, Ruth M L, Gilbert, Fiona J

“…Purpose: Magnetic resonance imaging (MRI) screening enables early detection of breast cancers in women with an inherited predisposition. Interval cancers…”
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Sensitivity to First-Line Chemotherapy for Metastatic Breast Cancer in BRCA1 and BRCA2 Mutation Carriers by KRIEGE, Mieke, SEYNAEVE, Caroline, VAN DEN OUWELAND, Ans, VAN GEEL, Bert, HOONING, Maartje J, BREKELMANS, Cecile T. M, KLIJN, Jan G. M, MEIJERS-HEIJBOER, Hanne, COLLEE, J. Margriet, MENKE-PLUYMERS, Marian B. E, BARTELS, Carina C. M, TILANUS-LINTHORST, Madeleine M. A, BLOM, Jannet, HUIJSKENS, Elisabeth, JAGER, Agnes

“…Preclinical as well as a few small retrospective, neoadjuvant studies suggest that breast cancer (cells) without functional BRCA1 or BRCA2 protein have an…”
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CHEK2 1100delC and male breast cancer in the Netherlands by Wasielewski, Marijke, den Bakker, Michael A, van den Ouweland, Ans, Meijer-van Gelder, Marion E, Portengen, Henk, Klijn, Jan G. M, Meijers-Heijboer, Hanne, Foekens, John A, Schutte, Mieke

“…Mutations in the breast cancer susceptibility genes BRCA1, BRCA2, and CHEK2 are known risk factors for female breast cancer. Mutations in BRCA1 and BRCA2 also…”
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Roles of Radiotherapy and Chemotherapy in the Development of Contralateral Breast Cancer by HOONING, Maartje J, ALEMAN, Berthe M. P, HAUPTMANN, Michael, BAAIJENS, Margreet H. A, KLIJN, Jan G. M, NOYON, Ruth, STOVALL, Marilyn, VAN LEEUWEN, Flora E

“…Few studies have examined whether modern radiotherapy and chemotherapy affect the risk of contralateral breast cancer (CBC), and results are inconclusive. We…”
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Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines by WASIELEWSKI, Marijke, ELSTRODT, Fons, KLIJN, Jan G. M, BERNS, Els M. J. J, SCHUTTE, Mieke

“…The p53 tumor suppressor gene is frequently mutated in breast cancer. Here, we used direct sequencing to screen the complete coding sequence of the p53 gene…”
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Four human breast cancer cell lines with biallelic inactivating α-catenin gene mutations by Hollestelle, Antoinette, Elstrodt, Fons, Timmermans, Mieke, Sieuwerts, Anieta M, Klijn, Jan G. M, Foekens, John A, den Bakker, Michael A, Schutte, Mieke

“…Mutations of E-cadherin have been identified in half of lobular breast cancers and diffuse-type gastric cancers, two tumor subtypes with remarkably similar…”
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HOXB13-to-IL17BR Expression Ratio Is Related With Tumor Aggressiveness and Response to Tamoxifen of Recurrent Breast Cancer: A Retrospective Study by JANSEN, Maurice P. H. M, SIEUWERTS, Anieta M, LOOK, Maxime P, RITSTIER, Kirsten, MEIJER-VAN GELDER, Marion E, VAN STAVEREN, Iris L, KLIJN, Jan G. M, FOEKENS, John A, BERNS, Els M. J. J

“…A HOXB13-to-IL17BR expression ratio was previously identified to predict clinical outcome of breast cancer patients treated with adjuvant tamoxifen. However,…”
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