Search Results - "Kligerman, Andrew D."

Effect of Treatment Media on the Agglomeration of Titanium Dioxide Nanoparticles: Impact on Genotoxicity, Cellular Interaction, and Cell Cycle by Prasad, Raju Y, Wallace, Kathleen, Daniel, Kaitlin M, Tennant, Alan H, Zucker, Robert M, Strickland, Jenna, Dreher, Kevin, Kligerman, Andrew D, Blackman, Carl F, DeMarini, David M

“…The widespread use of titanium dioxide (TiO2) nanoparticles in consumer products increases the probability of exposure to humans and the environment. Although…”
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Health effects of soy-biodiesel emissions: mutagenicity-emission factors by Mutlu, Esra, Warren, Sarah H., Matthews, Peggy P., King, Charly, Walsh, Leon, Kligerman, Andrew D., Schmid, Judith E., Janek, Daniel, Kooter, Ingeborg M., Linak, William P., Gilmour, M. Ian, DeMarini, David M.

“…Context: Soy biodiesel is the predominant biodiesel fuel used in the USA, but only a few, frequently conflicting studies have examined the potential health…”
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Cellular interactions and biological responses to titanium dioxide nanoparticles in HepG2 and BEAS-2B cells: Role of cell culture media by Prasad, Raju Y., Simmons, Steven O., Killius, Micaela G., Zucker, Robert M., Kligerman, Andrew D., Blackman, Carl F., Fry, Rebecca C., DeMarini, David M.

“…We showed previously that exposure of human lung cells (BEAS‐2B) to TiO2 nanoparticles (nano‐TiO2) produced micronuclei (MN) only when the final concentration…”
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Methylated Trivalent Arsenic Species Are Genotoxic by Mass, Marc J, Tennant, Alan, Roop, Barbara C, Cullen, William R, Styblo, Miroslav, Thomas, David J, Kligerman, Andrew D

“…The reactivities of methyloxoarsine (MAsIII) and iododimethylarsine (DMAsIII), two methylated trivalent arsenicals, toward supercoiled φX174 RFI DNA were…”
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Genotoxicity and metabolism of the source-water contaminant 1,1-dichloropropene: activation by GSTT1-1 and structure-activity considerations by Granville, Courtney A, Ross, Matthew K, Tornero-Velez, Rogelio, Hanley, Nancy M, Grindstaff, Rachel D, Gold, Avram, Richard, Ann M, Funasaka, Kunihiro, Tennant, Alan H, Kligerman, Andrew D, Evans, Marina V, DeMarini, David M

“…1,1-Dichloropropene (1,1-DCPe) is a contaminant of some source waters used to make drinking water. Because of this and the fact that no toxicological data were…”
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Superoxide dismutase protects cells from DNA damage induced by trivalent methylated arsenicals by Tennant, Alan H, Kligerman, Andrew D

“…Superoxide dismutase (SOD) catalyzes the conversion of superoxide to hydrogen peroxide. Heterozygous mice of strain B6;129S7-Sod1tm¹Leb/J were obtained from…”
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An evaluation of 25 selected ToxCast chemicals in medium-throughput assays to detect genotoxicity by Kligerman, Andrew D., Young, Robert R., Stankowski Jr, Leon F., Pant, Kamala, Lawlor, Tim, Aardema, Marilyn J., Houck, Keith A.

“…ToxCast is a multiyear effort to develop a cost‐effective approach for the US EPA to prioritize chemicals for toxicity testing. Initial evaluation of more than…”
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Cytogenetic insights into DNA damage and repair of lesions induced by a monomethylated trivalent arsenical by Kligerman, Andrew D., Malik, Shaukat I., Campbell, James A.

“…Arsenic is a human carcinogen, and only recently animal models have been developed that are useful in investigating its carcinogenic mode of action (MOA)…”
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Organoarsenicals. Uptake, metabolism, and toxicity by Dopp, Elke, Kligerman, Andrew D, Diaz-Bone, Roland A

“…Arsenic is categorized by the WHO as the most significant environmental contaminant of drinking water due to the prevalence of geogenic contamination of…”
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Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: Induction of chromosomal mutations but not gene mutations by Kligerman, Andrew D., Doerr, Carolyn L., Tennant, Alan H., Harrington-Brock, Karen, Allen, James W., Winkfield, Ernest, Poorman-Allen, Patricia, Kundu, Bijit, Funasaka, Kunihiro, Roop, Barbara C., Mass, Marc J., DeMarini, David M.

“…Arsenic is a prevalent human carcinogen whose mutagenicity has not been characterized fully. Exposure to either form of inorganic arsenic, AsIII or AsV, can…”
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Catalase has a key role in protecting cells from the genotoxic effects of monomethylarsonous acid: A highly active metabolite of arsenic by Muñiz Ortiz, Jorge G., Wallace, Kathleen A., Leinisch, Fabian, Kadiiska, Maria B., Mason, Ronald P., Kligerman, Andrew D.

“…Although it is widely known that arsenic‐contaminated drinking water causes many diseases, arsenic's exact mode of action (MOA) is not fully understood…”
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Arsenate and dimethylarsinic acid in drinking water did not affect DNA damage repair in urinary bladder transitional cells or micronuclei in bone marrow by Wang, Amy, Kligerman, Andrew D, Holladay, Steven D, Wolf, Douglas C, Robertson, John L

“…Arsenic is a human skin, lung, and urinary bladder carcinogen, and may act as a cocarcinogen in the skin and urinary bladder. Possible modes of action of…”
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Micronucleus studies in the peripheral blood and bone marrow of mice treated with jet fuels, JP-8 and Jet-A by Vijayalaxmi, Kligerman, Andrew D., Prihoda, Thomas J., Ullrich, Stephen E.

“…The potential adverse effects of dermal and inhalation exposure of jet fuels are important for health hazard evaluation in humans. The genotoxic potential of…”
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Measurement of DNA damage in rat urinary bladder transitional cells: Improved selective harvest of transitional cells and detailed Comet assay protocols by Wang, Amy, Robertson, John L., Holladay, Steven D., Tennant, Alan H., Lengi, Andrea J., Ahmed, S. Ansar, Huckle, William R., Kligerman, Andrew D.

“…Urinary bladder transitional epithelium is the main site of bladder cancer, and the use of transitional cells to study carcinogenesis/genotoxicity is…”
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Genotoxicity studies of three triazine herbicides: in vivo studies using the alkaline single cell gel (SCG) assay by Tennant, Alan H, Peng, Baocheng, Kligerman, Andrew D

“…Triazine herbicides are prevalent contaminants of groundwater in the agricultural regions of the United States. The literature on the genotoxicity of triazines…”
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Induction of DNA–protein crosslinks by dichloromethane in a V79 cell line transfected with the murine glutathione- S-transferase theta 1 gene by Hu, Yunping, Kabler, Sandra L., Tennant, Alan H., Townsend, Alan J., Kligerman, Andrew D.

“…Dichloromethane (DCM) is considered a probable human carcinogen. Laboratory studies have shown an increased incidence of lung and liver cancer in mice but not…”
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Cytogenetic studies of three triazine herbicides: II. In vivo micronucleus studies in mouse bone marrow by Kligerman, Andrew D., Doerr, Carolyn L., Tennant, Alan H., Peng, Baocheng

“…Atrazine, simazine, and cyanazine are widely used preemergence and postemergence triazine herbicides that have made their way into the potable water supply of…”
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Comparison of the genotoxic activities of the K-region dihydrodiol of benzo[ a]pyrene with benzo[ a]pyrene in mammalian cells: morphological cell transformation; DNA damage; and stable covalent DNA adducts by Nesnow, Stephen, Davis, Christine, Nelson, Garret B, Lambert, Guy, Padgett, William, Pimentel, Maria, Tennant, Alan H, Kligerman, Andrew D, Ross, Jeffrey A

“…Benzo[ a]pyrene (B[ a]P) is the most thoroughly studied polycyclic aromatic hydrocarbon (PAH). Many mechanisms have been suggested to explain its carcinogenic…”
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Cytogenetic studies of three triazine herbicides: I. In vitro studies by Kligerman, Andrew D, Doerr, Carolyn L, Tennant, Alan H, Zucker, Robert M

“…Atrazine, simazine, and cyanazine are widely used pre-emergence and post-emergence triazine herbicides that have made their way into the potable water supply…”
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An evaluation of the feasibility of using cytogenetic damage as a biomarker for alachlor exposure by Kligerman, Andrew D, Erexson, Gregory L

“…Alachlor is a widely used herbicide for which there is significant human exposure, principally through groundwater contamination and inhalation. Because…”
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