Search Results - "Klier, Margit"

The impact of cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index by SLOTTA-HUSPENINA, Julia, KOCH, Ina, DE LEVAL, Laurence, KELLER, Gisela, KLIER, Margit, BINK, Karin, KREMER, Marcus, RAFFELD, Mark, FEND, Falko, QUINTANILLA-MARTINEZ, Leticia

“…Mantle cell lymphoma is a clinically heterogeneous disease characterized by overexpression of cyclin D1 protein. Blastoid morphology, high proliferation, and…”
Get full text

C/EBPβ expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway by ANASTASOV, Natasa, BONZHEIM, Irina, QUINTANILLA-MARTINEZ, Leticia, RUDELIUS, Martina, KLIER, Margit, DAU, Therese, ANGERMEIER, Daniela, DUYSTER, Justus, PITTALUGA, Stefania, FEND, Falko, RAFFELD, Mark

“…Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma is characterized by the t(2;5) chromosomal translocation, resulting in the expression…”
Get full text

Differential diagnosis of cyclin D2+ mantle cell lymphoma based on fluorescence in situ hybridization and quantitative real-time-PCR by QUINTANILLA-MARTINEZ, Leticia, SLOTTA-HUSPENINA, Julia, KOCH, Ina, KLIER, Margit, HSI, Eric D, DE LEVAL, Laurence, KLAPPER, Wolfram, GESK, Stefan, SIEBERT, Reiner, FEND, Falko

“…Mantle cell lymphoma is characterized by the t(11;14) chromosomal translocation, resulting in the overexpression of cyclin D1 (CycD1). Recently, cases of…”
Get full text

Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes by Fasshauer, Mathias, Klein, Johannes, Kralisch, Susan, Klier, Margit, Lössner, Ulrike, Blüher, Matthias, Paschke, Ralf

“…The fat-derived protein adiponectin is an important insulin-sensitizing adipocytokine which is downregulated in insulin resistance and obesity. Recently, two…”
Get full text

Identification of C/EBPβ target genes in ALK+ anaplastic large cell lymphoma (ALCL) by gene expression profiling and chromatin immunoprecipitation by Bonzheim, Irina, Irmler, Martin, Klier-Richter, Margit, Steinhilber, Julia, Anastasov, Nataša, Schäfer, Sabine, Adam, Patrick, Beckers, Johannes, Raffeld, Mark, Fend, Falko, Quintanilla-Martinez, Leticia

“…C/EBPβ (CCAAT enhancer binding protein) is a transcription factor that plays a crucial role in survival and transformation of ALK+ anaplastic large cell…”
Get full text

Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes by Fasshauer, Mathias, Klein, Johannes, Kralisch, Susan, Klier, Margit, Lossner, Ulrike, Bluher, Matthias, Paschke, Ralf

“…During the last 10 years, various adipocytokines have been described which influence insulin sensitivity profoundly and might, therefore, potentially link…”
Get full text

Serum amyloid A3 expression is stimulated by dexamethasone and interleukin-6 in 3T3-L1 adipocytes by Fasshauer, Mathias, Klein, Johannes, Kralisch, Susan, Klier, Margit, Lossner, Ulrike, Bluher, Matthias, Paschke, Ralf

“…A chronic increase in systemic levels of acute-phase reactants contributes to the development of insulin resistance and associated disorders such as…”
Get full text

Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes by Fasshauer, Mathias, Kralisch, Susan, Klier, Margit, Lossner, Ulrike, Bluher, Matthias, Klein, Johannes, Paschke, Ralf

“…Recently, it has been shown that adiponectin is an important insulin-sensitizing fat-derived protein which is downregulated in insulin resistance and obesity,…”
Get full text

Expanding the Spectrum of Tumors With EWSR::WT1 Gene Fusion by a Peritoneal Case That Is Not a Desmoplastic Small Round Cell Tumor by Keil, Felix, Dietmaier, Wolfgang, Fürst, Alois, Klier-Richter, Margit, Oberschmid, Barbara, Evert, Matthias

Get full text

NPM-ALK–dependent expression of the transcription factor CCAAT/enhancer binding protein β in ALK-positive anaplastic large cell lymphoma by Quintanilla-Martinez, Leticia, Pittaluga, Stefania, Miething, Cornelius, Klier, Margit, Rudelius, Martina, Davies-Hill, Theresa, Anastasov, Natasa, Martinez, Antonio, Vivero, Angelica, Duyster, Justus, Jaffe, Elaine S., Fend, Falko, Raffeld, Mark

“…CCAAT/enhancer binding protein β (C/EBPβ) is one of a 6-member family of C/EBPs. These transcription factors are involved in the regulation of various aspects…”
Get full text

PTEN Regulates SYK-Directed AKT Activation in MCL by Rudelius, Martina, Pittaluga, Stefania, Sebasigari, Denise, Davies-Hill, Theresa, Klier, Margit, Quintanilla-Martinez, Leticia, Fend, Falko, Tabe, Yoko, Raffeld, Mark

“…Abstract 2941 Poster Board II-917 Mantle cell lymphoma (MCL) can be divided into two clinicopathologic subtypes, a common or “typical” form, and an aggressive…”
Get full text

Targeting CDK4 in Mantle Cell Lymphoma (MCL) Cell Lines by Specific Lentiviral shRNA Mediated Knockdown Has Profound Effects on Cell Growth and Cell Cycle but Minimal Effects on Apoptosis by Klier, Margit, Bonzheim, Irina, Anastasov, Natasa, Angermeier, Daniela, Raffeld, Mark, Fend, Falko, Quintanilla-Martinez, Leticia

“…Introduction: The hallmark of MCL is overexpression of cyclin D1 due to the t(11;14). Cyclin D1 accelerates the transition of lymphoma cells from G1 to S phase…”
Get full text

Gene Expression Profiling Reveals a Crucial Role for C/EBPbeta in Proliferation Pathways of ALK+ ALCL Cell Lines by Bonzheim, Irina, Irmler, Martin, Anastasov, Natasa, Klier, Margit, Beckers, Johannes, Pittaluga, Stefania, Fend, Falko, Raffeld, Mark, Quintanilla-Martinez, Leticia

“…Introduction: ALK+ anaplastic large cell lymphomas (ALCL) overexpress C/EBPβ, as a consequence of NPM-ALK kinase activity. C/EBPβ is a leucine zipper…”
Get full text

Functional Analysis of Cyclin D1 in Mantle Cell Lymphoma (MCL) by Specific Lentiviral shRNA Mediated Knockdown by Klier, Margit, Anastasov, Natasa, Angermeier, Daniela, Raffeld, Mark, Fend, Falko, Quintanilla-Martinez, Leticia

“…Introduction: Cyclin D1 overexpression is the hallmark of MCL. However, the importance of cyclin D1 for the maintenance of MCL still remains to be defined…”
Get full text

Interleukin-6 is a positive regulator of tumor necrosis factor α-induced adipose-related protein in 3T3-L1 adipocytes by Fasshauer, Mathias, Kralisch, Susan, Klier, Margit, Lossner, Ulrike, Bluher, Matthias, Chambaut-Guérin, Anne-Marie, Klein, Johannes, Paschke, Ralf

“…Tumor necrosis factor (TNF) α-induced adipose-related protein (TIARP) is a novel TNFα-stimulated protein in adipocytes. Besides TNFα, interleukin (IL)-6 has…”
Get full text

Efficient shRNA delivery into B and T lymphoma cells using lentiviral vector-mediated transfer by Anastasov, Nataša, Klier, Margit, Koch, Ina, Angermeier, Daniela, Höfler, Heinz, Fend, Falko, Quintanilla-Martinez, Leticia

“…RNA interference is a powerful tool for the functional analysis of proteins by specific gene knockdown. In this study, we devised a rapid and efficient way to…”
Get full text

Critical evaluation of molecular tumour board outcomes following 2 years of clinical practice in a Comprehensive Cancer Centre by Scheiter, Alexander, Hierl, Frederik, Lüke, Florian, Keil, Felix, Heudobler, Daniel, Einhell, Sabine, Klier-Richter, Margit, Konstandin, Nikola P., Weber, Florian, Scheiter, Andrea, Kandulski, Arne, Schlosser, Sophie, Cosma, Lidia-Sabina, Tews, Hauke, Weiss, Andreas R. R., Grube, Matthias, Bumes, Elisabeth, Hau, Peter, Proescholdt, Martin, Steger, Felix, Troeger, Anja, Haferkamp, Sebastian, Reibenspies, Lucas E., Schnabel, Marco J., Schulz, Christian, Drexler, Konstantin, Hatzipanagiotou, Maria E., Seitz, Stephan, Klinkhammer-Schalke, Monika, Unberath, Philipp, Calvisi, Diego F., Pukrop, Tobias, Dietmaier, Wolfgang, Evert, Matthias, Utpatel, Kirsten

“…Background Recently, molecular tumour boards (MTBs) have been integrated into the clinical routine. Since their benefit remains debated, we assessed MTB…”
Get full text

C/EBPβ Expression in ALK+ Anaplastic Large Cell Lymphomas (ALCL) Is Regulated by Stat3 Signaling Pathway by Anastasov, Natasa, Rudelius, Martina, Klier, Margit, Dau, Therese, Angermeier, Daniela, Pittaluga, Stefania, Duyster, Justus, Fend, Falko, Raffeld, Mark, Quintanilla-Martinez, Leticia

“…Background: ALK+ ALCL is characterized by the t(2;5) chromosomal translocation, resulting in the expression of a fusion protein called NPM-ALK. We recently…”
Get full text

Wnt/β-Catenin-Pathway Alterations and Homologous Recombination Deficiency in Cholangiocarcinoma Cell Lines and Clinical Samples: Towards Specific Vulnerabilities by Scheiter, Alexander, Hierl, Frederik, Winkel, Ingrid, Keil, Felix, Klier-Richter, Margit, Coulouarn, Cédric, Lüke, Florian, Kandulski, Arne, Evert, Matthias, Dietmaier, Wolfgang, Calvisi, Diego F., Utpatel, Kirsten

“…Cholangiocarcinoma (CCA) features a dismal prognosis with limited treatment options. Genomic studies have unveiled several promising targets in this disease,…”
Get full text

NPM-ALK-dependent expression of the transcription factor CCΑΑT/enhancer binding protein β in ALK-positive anaplastic large cell lymphoma by QUINTANILLA-MARTINEZ, Leticia, PITTALUGA, Stefania, JAFFE, Elaine S, FEND, Falko, RAFFELD, Mark, MIETHING, Cornelius, KLIER, Margit, RUDELIUS, Martina, DAVIES-HILL, Theresa, ANASTASOV, Natasa, MARTINEZ, Antonio, VIVERO, Angelica, DUYSTER, Justus

Get full text