Search Results - "Klickstein, LB"

Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis by Klickstein, L B, Shapleigh, C, Goetzl, E J

“…The predominant lipoxygenase products of arachidonic acid were extracted and purified from synovial fluid and sonicates of synovial tissue of patients with…”
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Complement receptor 1/CD35 is a receptor for mannan-binding lectin by Ghiran, I, Barbashov, S F, Klickstein, L B, Tas, S W, Jensenius, J C, Nicholson-Weller, A

“…Mannan-binding lectin (MBL), a member of the collectin family, is known to have opsonic function, although identification of its cellular receptor has been…”
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Calreticulin Is at the Surface of Circulating Neutrophils and Uses CD59 as an Adaptor Molecule by Ghiran, Ionita, Klickstein, Lloyd B., Nicholson-Weller, Anne

“…Calreticulin, which has been proposed to be a C1q receptor on neutrophils, has neither a transmembrane domain nor a GPI-anchor attachment site and must utilize…”
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RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes by Klickstein, Lloyd B, Cherry, Lisa K, Li, Xiaoyu, Schwab, Pascale, Lim, Bing

“…Lymphocyte function-associated antigen 1 (LFA-1) is relatively nonadhesive on resting lymphocytes; however, the mechanisms underlying changes in its…”
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Complement Receptor Type 1 (CR1, CD35) Is a Receptor for C1q by Klickstein, Lloyd B, Barbashov, Sergei F, Liu, Tun, Jack, Richard M, Nicholson-Weller, Anne

“…Molecular definition of the cellular receptor for the collagen domain of C1q has been elusive. We now report that C1q binds specifically to human CR1 (CD35),…”
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The Integrin α-Subunit Leg Extends at a Ca2+-Dependent Epitope in the Thigh/Genu Interface upon Activation by Xie, Can, Shimaoka, Motomu, Xiao, Tsan, Schwab, Pascale, Klickstein, Lloyd B., Springer, Timothy A.

“…Two activation-dependent Abs to the integrin α L-subunit were used to study conformational rearrangement of α Lβ 2 on the cell surface. Activation lowered the…”
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C1q-binding proteins and C1q receptors by Nicholson-Weller, Anne, Klickstein, Lloyd B

“…Aggregated or immobilized complement C1q induces cellular responses in many different cell types. C1q-induced cellular responses may be involved in host…”
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A Comparison of Type I Collagen, Fibronectin, and Vitronectin in Supporting Adhesion of Mechanically Strained Osteoblasts by Lacouture, Mario E., Schaffer, Jonathan L., Klickstein, Lloyd B.

“…We used an adhesion assay for cells cultured under high dynamic strain to measure human osteoblast‐like HOS cell adherence to immobilized type I collagen,…”
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C1q and C4b Bind Simultaneously to CR1 and Additively Support Erythrocyte Adhesion by Tas, Sander W, Klickstein, Lloyd B, Barbashov, Sergei F, Nicholson-Weller, Anne

“…Previously, we showed that soluble C1q bound specifically to CR1 on transfected cells. If the CR1-C1q interaction were to participate in immune complex…”
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Dual Role of H-Ras in Regulation of Lymphocyte Function Antigen-1 Activity by Stromal Cell-derived Factor-1α: Implications for Leukocyte Transmigration by Weber, Kim S.C., Ostermann, Georg, Zernecke, Alma, Schröder, Andreas, Klickstein, Lloyd B., Weber, Christian

“…We investigated the role of H-Ras in chemokine-induced integrin regulation in leukocytes. Stimulation of Jurkat T cells with the CXC chemokine stromal…”
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A transgenic mouse model for studying the clearance of blood‐borne pathogens via human complement receptor 1 (CR1) by Repik, A., Pincus, S. E., Ghiran, I., Nicholson‐Weller, A., Asher, D. R., Cerny, A. M., Casey, L. S., Jones, S. M., Jones, S. N., Mohamed, N., Klickstein, L. B., Spitalny, G., Finberg, R. W.

“…Summary Complement receptor 1 (CR1) on the surface of human erythrocytes facilitates intravascular clearance of complement‐opsonized pathogens. The need for…”
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Chemokine‐induced monocyte transmigration requires cdc42‐mediated cytoskeletal changes by Weber, Kim S. C., Klickstein, Lloyd B., Weber, Peter C., Weber, Christian

“…The ras‐related small GTPases of the rho family coordinate the assembly of complex cytoskeletal structures crucial for cell motility and polarization. Cdc42…”
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Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes by MATSUMOTO, A. K, MARTIN, D. R, CARTER, R. H, KLICKSTEIN, L. B, AHEARN, J. M, FEARON, D. T

“…The CD21/CD19/TAPA-1 complex of B lymphocytes amplifies signal transduction through membrane immunoglobulin (mIg), recruits phosphatidylinositol 3-kinase…”
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Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN by Weber, Kim S C, Alon, Ronen, Klickstein, Lloyd B

“…Intercellular adhesion molecule (ICAM)-2 is highly expressed on platelets and endothelium and is a counter-receptor for the leukocyte integrin, lymphocyte…”
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Expression and Function of C1q Receptors and C1q Binding Proteins at the Cell Surface by Ghiran, Ionita, Tyagi, Shiv-Raj, Klickstein, Lloyd B., Nicholson-Weller, Anne

“…C1q is the recognition unit of the first component of complement that binds not only IgG and IgM containing immune complexes, but also recognizes foreign…”
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Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1 by DE FOUGEROLLES, A. R, KLICKSTEIN, L. B, SPRINGER, T. A

“…Based on protein sequence, we have isolated a cDNA for intercellular adhesion molecule 3 (ICAM-3), the most recently defined counter-receptor for lymphocyte…”
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A Dominant Jurkat T Cell Mutation That Inhibits LFA-1-Mediated Cell Adhesion Is Associated with Increased Cell Growth by Cherry, Lisa K, Weber, Kim S. C, Klickstein, Lloyd B

“…LFA-1 exists in a low avidity state on resting leukocytes and is believed to adopt a high avidity state when the cells are exposed to a stimulus. Current…”
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Localization of the Binding Site on Intercellular Adhesion Molecule-3 (ICAM-3) for Lymphocyte Function-associated Antigen 1 (LFA-1) by Klickstein, L B, York, M R, Fougerolles, A R, Springer, T A

“…Intercellular adhesion molecule 3 (ICAM-3; CD50) is the predominant counter-receptor on resting T cells and monocytes for the leukocyte integrin, lymphocyte…”
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Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis by KLICKSTEIN, L. B, BARTOW, T. J, MILETIC, V, RABSON, L. D, SMITH, J. A, FEARON, D. T

“…Complementary DNA clones encoding the NH2-terminal region of human CR1 have been isolated and sequenced. The deduced complete amino acid sequence of the F…”
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Human C3b/C4b receptor (CR1): demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristic of C3/C4 binding proteins by KLICKSTEIN, L. B, WONG, W. W, SMITH, J. A, WEIS, J. H, WILSON, J. G, FEARON, D. T

“…The function of CR1 on B lymphocytes is less defined, although treatment of these cells with antibody to CR1 enhanced their response to suboptimal doses of PWM…”
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