Search Results - "Klickstein, L. B."

A transgenic mouse model for studying the clearance of blood‐borne pathogens via human complement receptor 1 (CR1) by Repik, A., Pincus, S. E., Ghiran, I., Nicholson‐Weller, A., Asher, D. R., Cerny, A. M., Casey, L. S., Jones, S. M., Jones, S. N., Mohamed, N., Klickstein, L. B., Spitalny, G., Finberg, R. W.

“…Summary Complement receptor 1 (CR1) on the surface of human erythrocytes facilitates intravascular clearance of complement‐opsonized pathogens. The need for…”
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Antibody CR1-2B11 recognizes a non-polymorphic epitope of human CR1 (CD35) by Chen, C.-H, Ghiran, I, Beurskens, F.J.M, Weaver, G, Vincent, J.A, Nicholson-Weller, A, Klickstein, L.B

“…Measurement of erythrocyte [red blood cells (RBC)] complement receptor type 1 (CR1, CD35) has the potential to serve as a sensitive assessment of complement…”
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Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes by MATSUMOTO, A. K, MARTIN, D. R, CARTER, R. H, KLICKSTEIN, L. B, AHEARN, J. M, FEARON, D. T

“…The CD21/CD19/TAPA-1 complex of B lymphocytes amplifies signal transduction through membrane immunoglobulin (mIg), recruits phosphatidylinositol 3-kinase…”
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Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis by KLICKSTEIN, L. B, BARTOW, T. J, MILETIC, V, RABSON, L. D, SMITH, J. A, FEARON, D. T

“…Complementary DNA clones encoding the NH2-terminal region of human CR1 have been isolated and sequenced. The deduced complete amino acid sequence of the F…”
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Expression and Function of C1q Receptors and C1q Binding Proteins at the Cell Surface by Ghiran, Ionita, Tyagi, Shiv-Raj, Klickstein, Lloyd B., Nicholson-Weller, Anne

“…C1q is the recognition unit of the first component of complement that binds not only IgG and IgM containing immune complexes, but also recognizes foreign…”
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Lack of age‐associated LFA‐1 up‐regulation and impaired ICAM‐1 binding in lymphocytes from patients with Down syndrome by Lin, S.‐J., Wang, J.‐Y., Klickstein, L. B., Chuang, K.‐P., Chen, J.‐Y., Lee, J.‐F., Shieh, C.‐C.

“…To investigate the role of LFA‐1 in the immune defects in DS patients, we analysed lymphocytes from DS patients in LFA‐1 expression and LFA‐1 mediated cell…”
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Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1 by DE FOUGEROLLES, A. R, KLICKSTEIN, L. B, SPRINGER, T. A

“…Based on protein sequence, we have isolated a cDNA for intercellular adhesion molecule 3 (ICAM-3), the most recently defined counter-receptor for lymphocyte…”
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A Dominant Jurkat T Cell Mutation That Inhibits LFA-1-Mediated Cell Adhesion Is Associated with Increased Cell Growth by Cherry, Lisa K, Weber, Kim S. C, Klickstein, Lloyd B

“…LFA-1 exists in a low avidity state on resting leukocytes and is believed to adopt a high avidity state when the cells are exposed to a stimulus. Current…”
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Complement receptor 1/CD35 is a receptor for mannan-binding lectin by Ghiran, I, Barbashov, S F, Klickstein, L B, Tas, S W, Jensenius, J C, Nicholson-Weller, A

“…Mannan-binding lectin (MBL), a member of the collectin family, is known to have opsonic function, although identification of its cellular receptor has been…”
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Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis by Klickstein, L B, Shapleigh, C, Goetzl, E J

“…The predominant lipoxygenase products of arachidonic acid were extracted and purified from synovial fluid and sonicates of synovial tissue of patients with…”
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Human C3b/C4b receptor (CR1): demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristic of C3/C4 binding proteins by KLICKSTEIN, L. B, WONG, W. W, SMITH, J. A, WEIS, J. H, WILSON, J. G, FEARON, D. T

“…The function of CR1 on B lymphocytes is less defined, although treatment of these cells with antibody to CR1 enhanced their response to suboptimal doses of PWM…”
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Cloning and Sequence Analysis of a Rat Liver cDNA Encoding Acyl-peptide Hydrolase by Kobayashi, K, Lin, L W, Yeadon, J E, Klickstein, L B, Smith, J A

“…Acyl-peptide hydrolase catalyzes the removal of an Nα-acetylated amino acid residue from an Nα-acetylated peptide. Two overlapping degenerate oligonucleotide…”
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Calreticulin Is at the Surface of Circulating Neutrophils and Uses CD59 as an Adaptor Molecule by Ghiran, Ionita, Klickstein, Lloyd B., Nicholson-Weller, Anne

“…Calreticulin, which has been proposed to be a C1q receptor on neutrophils, has neither a transmembrane domain nor a GPI-anchor attachment site and must utilize…”
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A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32 by Weis, JH, Morton, CC, Bruns, GA, Weis, JJ, Klickstein, LB, Wong, WW, Fearon, DT

“…The alternative or classical pathways for complement system component C3 may be triggered by microorganisms and antigen-antibody complexes. In particular, an…”
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Mapping of the epstein-barr virus and C3dg binding sites to a common domain on complement receptor type 2 by LOWELL, C. A, KLICKSTEIN, L. B, CARTER, R. H, MITCHELL, J. A, FEARON, D. T, AHEARN, J. M

“…Complement receptor type 2 (CR2;CD21), a member of the superfamily of proteins containing short consensus repeats (SCRs), is the B cell receptor for both the…”
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Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1 by CARROLL, M. C, ALICOT, E. M, KATZMAN, P. J, KLICKSTEIN, L. B, SMITH, J. A, FEARON, D. T

“…The organization and physical linkage of four members of a major complement locus, the RCA locus, have been determined using the technique of pulsed field…”
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Identification of a Partial cDNA Clone for the Human Receptor for Complement Fragments C3b/C4b by Wong, Winnie W., Klickstein, Lloyd B., Smith, John A., Weis, John H., Fearon, Douglas T.

“…Redundant oligonucleotides were synthesized based on amino acid sequences of tryptic peptides from the purified receptor for human complement fragments C3b/C4b…”
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Structure of the human CR1 gene: molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele by WONG, W. W, CAHILL, J. M, ROSEN, M. D, KENNEDY, C. A, BONACCIO, E. T, MORRIS, M. J, WILSON, J. G, KLICKSTEIN, L. B, FEARON, D. T

“…Structural and quantitative polymorphisms have been described in human CR1. In the former, the S allotype is larger than the F allotype by 40-50 kD, the size…”
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Complement Receptor Type 1 (CR1, CD35) Is a Receptor for C1q by Klickstein, Lloyd B, Barbashov, Sergei F, Liu, Tun, Jack, Richard M, Nicholson-Weller, Anne

“…Molecular definition of the cellular receptor for the collagen domain of C1q has been elusive. We now report that C1q binds specifically to human CR1 (CD35),…”
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The granulocyte-angiotensin system. Angiotensin I-converting activity of cathepsin G by Klickstein, L B, Kaempfer, C E, Wintroub, B U

“…Cathepsin G, an Mr = 26,000-29,000 cationic human neutrophil lysosomal serine protease, releases angiotensin II from angiotensinogen and was, therefore,…”
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