Search Results - "Kleppisch, Thomas"

Signaling through cGMP-Dependent Protein Kinase I in the Amygdala Is Critical for Auditory-Cued Fear Memory and Long-Term Potentiation by Paul, Cindy, Schoberl, Florian, Weinmeister, Pascal, Micale, Vincenzo, Wotjak, Carsten T, Hofmann, Franz, Kleppisch, Thomas

“…Long-term potentiation (LTP) of inputs relaying sensory information from cortical and thalamic neurons to principal neurons in the lateral amygdala (LA) is…”
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An essential role of Cav1.2 L‐type calcium channel for urinary bladder function by Wegener, Jörg W., Schulla, Verena, Lee, Tae‐Seong, Koller, Angela, Feil, Susanne, Feil, Robert, Kleppisch, Thomas, Klugbauer, Norbert, Moosmang, Sven, Welling, Andrea, Hofmann, Franz

“…ABSTRACT Mice deficient in the smooth muscle Cav1.2 calcium channel (SMACKO, smooth muscle α1c‐ subunit calcium channel knockout) have a severely reduced…”
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cGMP signalling in the mammalian brain: role in synaptic plasticity and behaviour by Kleppisch, Thomas, Feil, Robert

“…The second messenger cyclic guanosine 3',5'-monophosphate (cGMP) plays a crucial role in the control of cardiovascular and gastrointestinal homeostastis, but…”
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NO/cGMP-dependent modulation of synaptic transmission by Feil, Robert, Kleppisch, Thomas

“…Nitric oxide (NO) is a multifunctional messenger in the CNS that can signal both in antero- and retrograde directions across synapses. Many effects of NO are…”
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Frequency modulation of Ca2+ sparks is involved in regulation of arterial diameter by cyclic nucleotides by Porter, V A, Bonev, A D, Knot, H J, Heppner, T J, Stevenson, A S, Kleppisch, T, Lederer, W J, Nelson, M T

“…Forskolin, which elevates cAMP levels, and sodium nitroprusside (SNP) and nicorandil, which elevate cGMP levels, increased, by two- to threefold, the frequency…”
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Role of Hippocampal Cav1.2 Ca2+ Channels in NMDA Receptor-Independent Synaptic Plasticity and Spatial Memory by Moosmang, Sven, Haider, Nicole, Klugbauer, Norbert, Adelsberger, Helmuth, Langwieser, Nicolas, Muller, Jochen, Stiess, Michael, Marais, Else, Schulla, Verena, Lacinova, Lubica, Goebbels, Sandra, Nave, Klaus-Armin, Storm, Daniel R, Hofmann, Franz, Kleppisch, Thomas

“…Current knowledge about the molecular mechanisms of NMDA receptor (NMDAR)-independent long-term potentiation (LTP) in the hippocampus and its function for…”
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Phosphodiesterases in the central nervous system by Kleppisch, Thomas

“…Phosphodiesterases (PDEs) represent important cornerstones of cGMP signaling in various tissues. Since the discovery of PDE activity in 1962, it has become…”
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Calmodulin Kinase II Is Involved in Voltage-dependent Facilitation of the L-type Cav1.2 Calcium Channel by Lee, Tae-Seong, Karl, Rosi, Moosmang, Sven, Lenhardt, Peter, Klugbauer, Norbert, Hofmann, Franz, Kleppisch, Thomas, Welling, Andrea

“…Calcium-dependent facilitation of L-type calcium channels has been reported to depend on the function of calmodulin kinase II. In contrast, the mechanism for…”
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HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path by Matt, Lucas, Michalakis, Stylianos, Hofmann, Franz, Hammelmann, Verena, Ludwig, Andreas, Biel, Martin, Kleppisch, Thomas

“…Neuronal hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to modulate spontaneous activity, resting membrane potential, input…”
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Calmodulin Kinase II Is Involved in Voltage-dependent Facilitation of the L-type Cav1.2 Calcium Channel: IDENTIFICATION OF THE PHOSPHORYLATION SITES by Lee, Tae-Seong, Karl, Rosi, Moosmang, Sven, Lenhardt, Peter, Klugbauer, Norbert, Hofmann, Franz, Kleppisch, Thomas, Welling, Andrea

“…Calcium-dependent facilitation of L-type calcium channels has been reported to depend on the function of calmodulin kinase II. In contrast, the mechanism for…”
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Cav1.2 calcium channels modulate the spiking pattern of hippocampal pyramidal cells by Lacinova, Lubica, Moosmang, Sven, Langwieser, Nicole, Hofmann, Franz, Kleppisch, Thomas

“…Ca(v)1.2 L-type calcium channels support hippocampal synaptic plasticity, likely by facilitating dendritic Ca2+ influx evoked by action potentials (AP)…”
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Homeostatic switch in hebbian plasticity and fear learning after sustained loss of Cav1.2 calcium channels by Langwieser, Nicole, Christel, Carl J, Kleppisch, Thomas, Hofmann, Franz, Wotjak, Carsten T, Moosmang, Sven

“…Ca(2+) influx through postsynaptic Ca(v)1.x L-type voltage-gated channels (LTCCs) is particularly effective in activating neuronal biochemical signaling…”
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Formation of Postsynaptic-Like Membranes during Differentiation of Embryonic Stem Cellsin Vitro by Rohwedel, Jürgen, Kleppisch, Thomas, Pich, Uta, Guan, Kaomei, Jin, Shan, Zuschratter, Werner, Hopf, Carsten, Hoch, Werner, Hescheler, Jürgen, Witzemann, Veit, Wobus, Anna M.

“…To analyze the formation of neuromuscular junctions, mouse pluripotent embryonic stem (ES) cells were differentiated via embryoid bodies into skeletal muscle…”
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Gα q -Deficient Mice Lack Metabotropic Glutamate Receptor-Dependent Long-Term Depression But Show Normal Long-Term Potentiation in the Hippocampal CA1 Region by Kleppisch, Thomas, Voigt, Viktor, Allmann, Rüdiger, Offermanns, Stefan

“…Long-term potentiation (LTP) and depression (LTD) are potential cellular mechanisms involved in learning and memory. Group I metabotropic glutamate receptors…”
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Mechanisms of NO/cGMP-Dependent Vasorelaxation by Sausbier, Matthias, Schubert, Rudolf, Voigt, Viktor, Hirneiss, Christoph, Pfeifer, Alexander, Korth, Michael, Kleppisch, Thomas, Ruth, Peter, Hofmann, Franz

“…ABSTRACT—Both cGMP-dependent and -independent mechanisms have been implicated in the regulation of vascular tone by NO. We analyzed acetylcholine (ACh)- and…”
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Function of cGMP-dependent protein kinases in the nervous system by Feil, Robert, Hofmann, Franz, Kleppisch, Thomas

“…The second messenger cyclic guanosine-3',5'-monophosphate (cGMP) mediates many effects of nitric oxide in the nervous system. cGMP may act through various…”
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cGMP-dependent protein kinase Type I promotes CREB/CRE-mediated gene expression in neurons of the lateral amygdala by Paul, Cindy, Stratil, Christopher, Hofmann, Franz, Kleppisch, Thomas

“…The process transforming newly learned information into stable long-term memory is called memory consolidation and, like the underlying long-term synaptic…”
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Impairment of long‐term facilitation (LTF) of respiratory motor outputs following intermittent hypoxia and response to hypercapnia in HCN2‐deficient mice by Dutschmann, Mathias, Ludwig, Andreas, Kleppisch, Thomas

“…HCN2 channels are hyperpolarization‐activated cyclic nucleotide‐gated channels proposed to function as pacemaker channels the sinoatrial node. The role of HCN…”
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Ca sub(v1.2 calcium channels modulate the spiking pattern of hippocampal pyramidal cells) by Lacinova, Lubica, Moosmang, Sven, Langwieser, Nicole, Hofmann, Franz, Kleppisch, Thomas

“…Ca sub(v1.2 L-type calcium channels support hippocampal synaptic plasticity, likely by facilitating dendritic Ca) super(2)+ influx evoked by action potentials…”
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Ca sub(v)1.2 calcium channels modulate the spiking pattern of hippocampal pyramidal cells by Lacinova, Lubica, Moosmang, Sven, Langwieser, Nicole, Hofmann, Franz, Kleppisch, Thomas

“…Ca sub(v)1.2 L-type calcium channels support hippocampal synaptic plasticity, likely by facilitating dendritic Ca super(2+) influx evoked by action potentials…”
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