Search Results - "Kleppe, Laurel"

The thrombin receptor modulates astroglia‐neuron trophic coupling and neural repair after spinal cord injury by Kim, Ha Neui, Triplet, Erin M., Radulovic, Maja, Bouchal, Samantha, Kleppe, Laurel S., Simon, Whitney L., Yoon, Hyesook, Scarisbrick, Isobel A.

“…Excessive activation of the thrombin receptor, protease activated receptor 1 (PAR1) is implicated in diverse neuropathologies from neurodegenerative conditions…”
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Characterization of a Resident Population of Adventitial Macrophage Progenitor Cells in Postnatal Vasculature by Psaltis, Peter J, Puranik, Amrutesh S, Spoon, Daniel B, Chue, Colin D, Hoffman, Scott J, Witt, Tyra A, Delacroix, Sinny, Kleppe, Laurel S, Mueske, Cheryl S, Pan, Shuchong, Gulati, Rajiv, Simari, Robert D

“…RATIONALE:Macrophages regulate blood vessel structure and function in health and disease. The origins of tissue macrophages are diverse, with evidence for…”
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Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain by Yoon, Hyesook, Choi, Chan-Il, Triplet, Erin M, Langley, Monica R, Kleppe, Laurel S, Kim, Ha Neui, Simon, Whitney L, Scarisbrick, Isobel A

“…Myelin loss limits neurological recovery and myelin regeneration and is critical for restoration of function. We recently discovered that global knock-out of…”
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Blocking Kallikrein 6 promotes developmental myelination by Yoon, Hyesook, Triplet, Erin M., Simon, Whitney L., Choi, Chan‐Il, Kleppe, Laurel S., De Vita, Elena, Miller, Aubry K., Scarisbrick, Isobel A.

“…Kallikrein related peptidase 6 (Klk6) is a secreted serine protease highly expressed in oligodendrocytes and implicated in demyelinating conditions. To gain…”
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The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury by Triplet, Erin M., Kim, Ha Neui, Yoon, Hyesook, Radulovic, Maja, Kleppe, Laurel, Simon, Whitney L., Choi, Chan-il, Walsh, Patrick J., Dutton, James R., Scarisbrick, Isobel A.

“…Despite concerted efforts to identify CNS regeneration strategies, an incomplete understanding of how the needed molecular machinery is regulated limits…”
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Identification of a Monocyte-Predisposed Hierarchy of Hematopoietic Progenitor Cells in the Adventitia of Postnatal Murine Aorta by PSALTIS, Peter J, HARBUZARIU, Adriana, GULATI, Rajiv, SANDHU, Gurpreet S, SIMARI, Robert D, DELACROIX, Sinny, WITT, Tyra A, HOLROYD, Eric W, SPOON, Daniel B, HOFFMAN, Scott J, SHUCHONG PAN, KLEPPE, Laurel S, MUESKE, Cheryl S

“…Hematopoiesis originates from the dorsal aorta during embryogenesis. Although adult blood vessels harbor progenitor populations for endothelial and smooth…”
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Cell surface protein disulfide isomerase regulates natriuretic peptide generation of cyclic guanosine monophosphate by Pan, Shuchong, Chen, Horng H, Correia, Cristina, Dai, Haiming, Witt, Tyra A, Kleppe, Laurel S, Burnett, Jr, John C, Simari, Robert D

“…The family of natriuretic peptides (NPs), including atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and C-type natriuretic peptide (CNP),…”
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Autologous culture-modified mononuclear cells confer vascular protection after arterial injury by GULATI, Rajiv, JEVREMOVIC, Dragan, PETERSON, Timothy E, WITT, Tyra A, KLEPPE, Laurel S, MUESKE, Cheryl S, LERMAN, Amir, VILE, Richard G, SIMARI, Robert D

“…Bone marrow-derived cells have been shown to contribute to endothelial replacement after vascular injury. In vitro culture of peripheral blood mononuclear…”
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Biodesign of a renal-protective peptide based on alternative splicing of B-type natriuretic peptide by Pan, Shuchong, Chen, Horng H, Dickey, Deborah M, Boerrigter, Guido, Lee, Candace, Kleppe, Laurel S, Hall, Jennifer L, Lerman, Amir, Redfield, Margaret M, Potter, Lincoln R, Burnett, John C. Jr, Simari, Robert D

“…Alternative RNA splicing may provide unique opportunities to identify drug targets and therapeutics. We identified an alternative spliced transcript for B-type…”
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Tissue Factor Pathway Inhibitor Blocks Angiogenesis via Its Carboxyl Terminus by Holroyd, Eric W, Delacroix, Sinny, Larsen, Katarina, Harbuzariu, Adriana, Psaltis, Peter J, Wang, Ling, Pan, Shuchong, White, Thomas A, Witt, Tyra A, Kleppe, Laurel S, Mueske, Cheryl S, Mukhopadhyay, Debabrata, Simari, Robert D

“…OBJECTIVE—Tissue factor pathway inhibitor (TFPI) is the primary regulator of the tissue factor (TF) coagulation pathway. As such, TFPI may regulate the…”
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A Western diet impairs CNS energy homeostasis and recovery after spinal cord injury: Link to astrocyte metabolism by Kim, Ha Neui, Langley, Monica R., Simon, Whitney L., Yoon, Hyesook, Kleppe, Laurel, Lanza, Ian R., LeBrasseur, Nathan K., Matveyenko, Aleksey, Scarisbrick, Isobel A.

“…A diet high in fat and sucrose (HFHS), the so-called Western diet promotes metabolic syndrome, a significant co-morbidity for individuals with spinal cord…”
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The effect of vascular smooth muscle cell-targeted expression of tissue factor pathway inhibitor in a murine model of arterial thrombosis by Pan, Shuchong, Kleppe, Laurel S, Witt, Tyra A, Mueske, Cheryl S, Simari, Robert D

“…Tissue factor pathway inhibitor (TFPI) is a Kunitz-type protease inhibitor that regulates the extrinsic pathway of coagulation by inhibiting the factor…”
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Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis by Caplice, Noel M., Panetta, Carmelo, Peterson, Timothy E., Kleppe, Laurel S., Mueske, Cheryl S., Kostner, Gert M., Broze, George J., Simari, Robert D.

“…Lipoprotein (a) [Lp(a)] has been associated with both anti-fibrinolytic and atherogenic effects. However, no direct link currently exists between this…”
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Tissue factor pathway inhibitor overexpression inhibits hypoxia-induced pulmonary hypertension by White, Thomas A, Witt, Tyra A, Pan, Shuchong, Mueske, Cheryl S, Kleppe, Laurel S, Holroyd, Eric W, Champion, Hunter C, Simari, Robert D

“…Pulmonary hypertension (PH) is a commonly recognized complication of chronic respiratory disease. Enhanced vasoconstriction, pulmonary vascular remodeling, and…”
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Modulation of the vascular response to injury by autologous blood-derived outgrowth endothelial cells by Gulati, Rajiv, Jevremovic, Dragan, Witt, Tyra A, Kleppe, Laurel S, Vile, Richard G, Lerman, Amir, Simari, Robert D

“…Delivery of a heterogeneous population of cells with endothelial phenotype derived from peripheral blood has been shown to improve vascular responses after…”
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Caveolin-1 Can Regulate Vascular Smooth Muscle Cell Fate by Switching Platelet-Derived Growth Factor Signaling From a Proliferative to an Apoptotic Pathway by Peterson, Timothy E, Guicciardi, Maria E, Gulati, Rajiv, Kleppe, Laurel S, Mueske, Cheryl S, Mookadam, Martina, Sowa, Grzegorz, Gores, Gregory J, Sessa, William C, Simari, Robert D

“…BACKGROUND—Caveolin-1 is a regulator of signaling events originating from plasma membrane microdomains termed caveolae. This study was performed to determine…”
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Carotid Repair Using Autologous Adipose-Derived Endothelial Cells by FROEHLICH, Harald, GULATI, Rajiv, BOILSON, Barry, WITT, Tyra, HARBUZARIU, Adriana, KLEPPE, Laurel, DIETZ, Allan B, LERMAN, Amir, SIMARI, Robert D

“…Adipose tissue is an abundant source of endothelial cells as well as stem and progenitor cells which can develop an endothelial phenotype. It has been…”
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Use of blood outgrowth endothelial cells as virus-producing vectors for gene delivery to tumors by Jevremovic, Dragan, Gulati, Rajiv, Hennig, Ivo, Diaz, Rosa Maria, Cole, Caroline, Kleppe, Laurel, Cosset, Francois Loic, Simari, Robert D, Vile, Richard G

“…Cell-based delivery of therapeutic viruses has potential advantages over systemic viral administration, including attenuated neutralization and improved viral…”
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Tissue factor pathway inhibitor deficiency enhances neointimal proliferation and formation in a murine model of vascular remodelling by Singh, Ripudamanjit, Pan, Shuchong, Mueske, Cheryl S, Witt, Tyra A, Kleppe, Laurel S, Peterson, Timothy E, Caplice, Noel M, Simari, Robert D

“…Tissue factor (TF) is a small-molecular-weight glycoprotein that initiates the extrinsic coagulation pathway but may have important noncoagulation vascular…”
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Presence of tissue factor pathway inhibitor in human atherosclerotic plaques is associated with reduced tissue factor activity by CAPLICE, N. M, MUESKE, C. S, KLEPPE, L. S, SIMARI, R. D

“…Plaque disruption and exposure of subendothelial procoagulants such as tissue factor (TF) to circulating factor VII/VIIa (FVII/VIIa) lead to intravascular…”
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