Search Results - "Klemsz, Michael J"

Inhibition of MEK signaling prevents SARS‐CoV2‐induced lung damage and improves the survival of infected mice by Xie, Jingwu, Klemsz, Michael J., Kacena, Melissa A., Sandusky, George, Zhang, Xiaoli, Kaplan, Mark H.

“…Coronavirus disease 2019 (COVID‐19) is the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Over 500 million confirmed cases of…”
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Osteoclast-mediated bone loss observed in a COVID-19 mouse model by Awosanya, Olatundun D., Dalloul, Christopher E., Blosser, Rachel J., Dadwal, Ushashi C., Carozza, Mariel, Boschen, Karen, Klemsz, Michael J., Johnston, Nancy A., Bruzzaniti, Angela, Robinson, Christopher M., Srour, Edward F., Kacena, Melissa A.

“…The consequences of SARS-CoV-2 infection on the musculoskeletal system represent a dangerous knowledge gap. Aging patients are at added risk for SARS-CoV-2…”
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Cathepsin E: A Novel Target for Regulation by Class II Transactivator by Yee, Christina S. K, Yao, Yongxue, Li, Ping, Klemsz, Michael J, Blum, Janice S, Chang, Cheong-Hee

“…The aspartic proteinase cathepsin E (CatE) has been implicated in Ag processing. In this study we report that CatE expression is negatively regulated by the…”
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Oral immunotherapy with type V collagen in idiopathic pulmonary fibrosis by Wilkes, David S, Chew, Terrence, Flaherty, Kevin R, Frye, Sarah, Gibson, Kevin F, Kaminski, Naftali, Klemsz, Michael J, Lange, Wade, Noth, Imre, Rothhaar, Katia

“…Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. IPF appears to be heterogeneous in pathobiology with ∼40% of IPF…”
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Regulation of the PU.1 gene by distal elements by Li, Youlin, Okuno, Yutaka, Zhang, Pu, Radomska, Hanna S., Chen, Hui-min, Iwasaki, Hiromi, Akashi, Koichi, Klemsz, Michael J., McKercher, Scott R., Maki, Richard A., Tenen, Daniel G.

“…The transcription factor PU.1 (also known as Spi-1) plays a critical role in the development of the myeloid lineages, and myeloid cells derived from PU.1−/−…”
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p38 activation through Toll-like receptors modulates IFN-γ-induced expression of the Tap-1 gene only in macrophages by Cecil, Alicia A., Klemsz, Michael J.

“…Although interferon‐γ (IFN‐γ) induces the transporter associated with antigen processing (Tap)‐1 expression in macrophages, cooperation with lipopolysaccharide…”
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PU.1 regulates glutathione peroxidase expression in neutrophils by Throm, Stacy L., Klemsz, Michael J.

“…Based on knockout models, the transcription factor PU.1 has been shown to be important for the maturation of neutrophils. As the list of genes PU.1 directly…”
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PU.1 Expression Delineates Heterogeneity in Primary Th2 Cells by Chang, Hua-Chen, Zhang, Shangming, Thieu, Vivian T., Slee, Roger B., Bruns, Heather A., Laribee, R. Nicholas, Klemsz, Michael J., Kaplan, Mark H.

“…Primary T helper 2 cells are heterogeneous, expressing subsets of cytokines at varying levels. Mechanisms controlling this spectrum of phenotypes are still…”
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Cutting edge: induction of the antigen-processing enzyme IFN-gamma-inducible lysosomal thiol reductase in melanoma cells Is STAT1-dependent but CIITA-independent by O'Donnell, Patrick W, Haque, Azizul, Klemsz, Michael J, Kaplan, Mark H, Blum, Janice S

“…Presentation and CD4(+) T cell responses to Ag in the context of MHC class II molecules require processing of native proteins into short peptide fragments…”
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Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons by Mann, Brandon A, Huang, Julia He, Li, Ping, Chang, Hua-Chen, Slee, Roger B, O'Sullivan, Audrey, Anita, Mathur, Yeh, Norman, Klemsz, Michael J, Brutkiewicz, Randy R, Blum, Janice S, Kaplan, Mark H

“…Blocking the function of Stat (signal transducer and activator of transcription) proteins, which are critical for antiviral responses, has evolved as a common…”
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Human papillomavirus type 16 E7 protein increases acetylation of histone H3 in human foreskin keratinocytes by Zhang, Benyue, Laribee, R. Nicholas, Klemsz, Michael J., Roman, Ann

“…Histone acetylation plays an important role in chromatin remodeling and transcription control. Acetylation of histones is regulated by histone…”
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Pillars article: the macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell, 1990. 61: 113-124 by Klemsz, Michael J, McKercher, Scott R, Celada, Antonio, Van Beveren, Charles, Maki, Richard A

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Loss of PU.1 Expression Following Inhibition of Histone Deacetylases by Laribee, R. Nicholas, Klemsz, Michael J

“…Altering chromatin structure by blocking histone deacetylase activity with specific inhibitors such as trichostatin A can result in an up-regulation of gene…”
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The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene by Klemsz, M J, McKercher, S R, Celada, A, Van Beveren, C, Maki, R A

“…We have isolated a cDNA clone, PU.1, that codes for a new tissue-specific DNA binding protein. Analysis of the binding site by methylation interference and…”
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Effect of PU.1 Phosphorylation on Interaction with NF-EM5 and Transcriptional Activation by Jagan M. R. Pongubala, Van Beveren, Charles, Nagulapalli, Sujatha, Klemsz, Michael J., McKercher, Scott R., Maki, Richard A., Atchison, Michael L.

“…PU.1 recruits the binding of a second B cell-restricted nuclear factor, NF-EM5, to a DNA site in the immunoglobulin κ 3′ enhancer. DNA binding by NF-EM5…”
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PU.1 Is a Lineage-specific Regulator of Tyrosine Phosphatase CD45 by Anderson, Karen L., Nelson, Stacy L., Perkin, Hugh B., Smith, Kent A., Klemsz, Michael J., Torbett, Bruce E.

“…The hematopoietic cell-specific etsfamily transcription factor PU.1 regulates many lymphoid and myeloid genes. We have determined that PU.1 is critical for…”
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Methylation of an ETS site in the intron enhancer of the keratin 18 gene participates in tissue-specific repression by Umezawa, Akihiro, Yamamoto, Hideyuki, Rhodes, Katherine, Klemsz, Michael J., Maki, Richard A., Oshima, Robert G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Histone H4 HDAC activity is necessary for expression of the PU.1 gene by Laribee, R. Nicholas, Klemsz, Michael J.

“…Although the current paradigm delegates histone deacetylases (HDACs) to the role of transcriptional co-repressors, we recently showed that HDAC activity was…”
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Poxvirus phosphatase alters interferon gamma regulated gene expression in macrophages by Hite, Andre, Klemsz, Michael J

“…Poxviruses including Variola (small pox), and Vaccinia, which is used to vaccinate against small pox have developed numerous methods for altering and/or…”
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Cloning and characterization of Exodus, a novel β-chemokine by HROMAS, R, GRAY, P. W, COOPER, S, BROXMEYER, H. E, KLEMSZ, M. J, CHANTRY, D, GODISKA, R, KRATHWOHL, M, FIFE, K, BELL, G. I, TAKEDA, J, ARONICA, S, GORDON, M

“…Chemokines are a family of related proteins that regulate leukocyte infiltration into inflamed tissue. Some chemokines such as MIP-1 alpha also inhibit…”
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