Search Results - "Klempan, T"

Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression by Klempan, T A, Sequeira, A, Canetti, L, Lalovic, A, Ernst, C, ffrench-Mullen, J, Turecki, G

“…The prefrontal cortex is believed to play a major role in depression and suicidal behavior through regulation of cognition, memory, recognition of emotion, and…”
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Patterns of gene expression in the limbic system of suicides with and without major depression by SEQUEIRA, A, KLEMPAN, T, CANETTI, L, FFRENCH-MULLEN, J, BENKELFAT, C, ROULEAU, G. A, TURECKI, G

“…The limbic system has consistently been associated with the control of emotions and with mood disorders. The goal of this study was to identify new molecular…”
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Stimulation of serotonergic 5-HT2A receptor signaling increases placental aromatase (CYP19) activity and expression in BeWo and JEG-3 human choriocarcinoma cells by Klempan, T, Hudon-Thibeault, A.-A, Oufkir, T, Vaillancourt, C, Sanderson, J.T

“…Abstract It is known that serotonin can influence the production and function of sex hormones, such as estrogens. Estrogens are critical for maintenance of…”
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Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3η gene by WONG, A. H. C, MACCIARDI, F, OAK, J, AZEVEDO, M-H, DOURADO, A, COELHO, I, MACEDO, A, VICENTE, A, VALENTE, J, FERREIRA, C. P, PATO, M. T, PATO, C. N, KLEMPAN, T, KENNEDY, J. L, VAN TOL, H. H. M, KAWCZYNSKI, W, BARR, C. L, LAKATOO, S, WONG, M, BUCKLE, C, TRAKALO, J, BOFFA, E

“…Although the genetic contribution to schizophrenia is substantial, positive findings in whole-genome linkage scans have not been consistently replicated. We…”
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Molecular Characterization of a MSRV-like Sequence Identified by RDA from Monozygotic Twin Pairs Discordant for Schizophrenia by Deb-Rinker, Paromita, Klempan, Timothy A., O'Reilly, Richard L., Torrey, E.Fuller, Singh, Shiva M.

“…Retroviral-related amplicons were used in modified RDA to identify four sequences from affected members of three pairs of monozygotic twins discordant for…”
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Search for unstable DNA in schizophrenia families with evidence for genetic anticipation by PETRONIS, A, BASSETT, A. S, HONER, W. G, VINCENT, J. B, TATUCH, Y, SASAKI, T, YING, D.-J, KLEMPAN, T. A, KENNEDY, J. L

“…Evidence for genetic anticipation has recently become an important subject of research in clinical psychiatric genetics. Renewed interest in anticipation was…”
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Frequency analysis of large CAG/CTG trinucleotide repeats in schizophrenia and bipolar affective disorder by Vincent, J B, Klempan, T, Parikh, S S, Sasaki, T, Meltzer, H Y, Sirugo, G, Cola, P, Petronis, A, Kennedy, J L

“…Much interest has recently been focussed on the possibility of the involvement of unstable DNA in the etiology of schizophrenia and bipolar affective disorder…”
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No evidence of expansion of CAG or GAA repeats in schizophrenia families and monozygotic twins by VINCENT, J. B, KALSI, G, GOTTESMAN, I. I, TORREY, E. F, PETRONIS, A, KENNEDY, J. L, KLEMPAN, T, TATUCH, Y, SHERRINGTON, R. P, BRESCHEL, T, MCINNIS, M. G, BRYNJOLFSSON, J, PETURSSON, H, GURLING, H. M. D

“…Many diseases caused by trinucleotide expansion exhibit increased severity and decreased age of onset (genetic anticipation) in successive generations…”
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Stimulation of serotonergic 5-HT 2A receptor signaling increases placental aromatase (CYP19) activity and expression in BeWo and JEG-3 human choriocarcinoma cells by Klempan, T., Hudon-Thibeault, A.-A., Oufkir, T., Vaillancourt, C., Sanderson, J.T.

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Search for retroviral related DNA polymorphisms using RAPD PCR in schizophrenia by Deb, Paromita, Klempan, Timothy A., O’Reilly, Richard L., Singh, Shiva M.

“…Random amplification of polymorphic DNA (RAPD) is widely used to detect polymorphisms in many organisms. Individual (or strain) specific amplified bands are…”
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A single-primer PCR-based retroviral-related DNA polymorphism shared by two distinct human populations by Deb, P, Klempan, T A, O'Reilly, R L, Singh, S M

“…Almost 10% of the human genome consists of DNA sequences that share homology with retroviruses. These sequences, which represent a stable component of the…”
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Suicide: a neurobiological point of view by Klempan, Tim, Turecki, Gustavo

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Association between schizophrenia and the syntaxin 1A gene by Wong, Albert H.C., Trakalo, Joseph, Likhodi, Olga, Yusuf, Muneeb, Macedo, Antonio, Azevedo, Maria-Helena, Klempan, Tim, Pato, Michele T., Honer, William G., Pato, Carlos N., Van Tol, Hubert H.M., Kennedy, James L.

“…Both microarray and candidate molecule studies have demonstrated that protein and mRNA expression of syntaxin and other genes involved in synaptic function are…”
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The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia by Müller, Daniel J., Klempan, Tim A., De Luca, Vincenzo, Sicard, Tricia, Volavka, Jan, Czobor, Pal, Sheitman, Brian B., Lindenmayer, Jean-Pierre, Citrome, Leslie, McEvoy, Joseph P., Lieberman, Jeffrey A., Honer, William G., Kennedy, James L.

“…The synaptosomal-associated protein of 25 kDa (SNAP-25) is an essential component of the core complex that mediates presynaptic vesicle trafficking. Thus,…”
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Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3eta gene by Wong, A H C, Macciardi, F, Klempan, T, Kawczynski, W, Barr, C L, Lakatoo, S, Wong, M, Buckle, C, Trakalo, J, Boffa, E, Oak, J, Azevedo, M-H, Dourado, A, Coelho, I, Macedo, A, Vicente, A, Valente, J, Ferreira, C P, Pato, M T, Pato, C N, Kennedy, J L, Van Tol, H H M

“…Although the genetic contribution to schizophrenia is substantial, positive findings in whole-genome linkage scans have not been consistently replicated. We…”
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Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3 gene by Wong, A H C, Macciardi, F, Klempan, T, Kawczynski, W, Barr, C L, Lakatoo, S, Wong, M, Buckle, C, Trakalo, J, Boffa, E, Oak, J, M-H Azevedo, Dourado, A, Coelho, I, Macedo, A, Vicente, A, Valente, J, Ferreira, C P, Pato, M T, Pato, C N, Kennedy, J L, H H M Van Tol

“…Although the genetic contribution to schizophrenia is substantial, positive findings in whole-genome linkage scans have not been consistently replicated. We…”
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Direct detection of expanded trinucleotide repeats using PCR and DNA hybridization techniques by Petronis, Arturas, Heng, Henry H. Q., Tatuch, Yuriy, Shi, Xiao-Mei, Klempan, Timothy A., Tsui, Lap-Chee, Ashizawa, Tetsuo, Surh, Linda C., Holden, Jeanette J. A., Kennedy, James L.

“…Recently, unstable trinucleotide repeats have been shown to be the etiologic factor in seven neuropsychiatric diseases, and they may play a similar role in…”
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NOTCH4 gene haplotype is associated with schizophrenia in African Americans by Luo, Xingguang, Klempan, Tim A, Lappalainen, Jaakko, Rosenheck, Robert A, Charney, Dennis S, Erdos, Joseph, van Kammen, Daniel P, Kranzler, Henry R, Kennedy, James L, Gelernter, Joel

“…The goal of this study was to investigate the relationship between the NOTCH4 gene and schizophrenia in African American (AA) and European American (EA)…”
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Molecular genetics of neurodevelopment and treatment response in psychosis by Kennedy, JL, Klempan, T, Mueller, D, Wong, A, Volavka, J, Czobor, P, Lieberman, J

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Direct detection of expanded trinucleotide repeats using PCR and DNR hybridization techniques by PETRONIS, A, HENG, H. H. Q, TATUCH, Y, SHI, X.-M, KLEMPAN, T. A, TSUI, L.-C, ASHIZAWA, T, SURH, L. C, HOLDEN, J. J. A, KENNEDY, J. L

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