Search Results - "Klemm, Lars"

Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia by Swaminathan, Srividya, Klemm, Lars, Park, Eugene, Papaemmanuil, Elli, Ford, Anthony, Kweon, Soo-Mi, Trageser, Daniel, Hasselfeld, Brian, Henke, Nadine, Mooster, Jana, Geng, Huimin, Schwarz, Klaus, Kogan, Scott C, Casellas, Rafael, Schatz, David G, Lieber, Michael R, Greaves, Mel F, Müschen, Markus

“…Secondary mutations can drive the transformation of pre-leukemic clones that carry ETV6 - RUNX1 translocations. Müschen and colleagues show that repeated…”
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Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia by Shojaee, Seyedmehdi, Caeser, Rebecca, Buchner, Maike, Park, Eugene, Swaminathan, Srividya, Hurtz, Christian, Geng, Huimin, Chan, Lai N., Klemm, Lars, Hofmann, Wolf-Karsten, Qiu, Yi Hua, Zhang, Nianxiang, Coombes, Kevin R., Paietta, Elisabeth, Molkentin, Jeffery, Koeffler, H. Phillip, Willman, Cheryl L., Hunger, Stephen P., Melnick, Ari, Kornblau, Steven M., Müschen, Markus

“…Studying mechanisms of malignant transformation of human pre-B cells, we found that acute activation of oncogenes induced immediate cell death in the vast…”
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Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy by Hsieh, Yao-Te, Gang, Eun Ji, Geng, Huimin, Park, Eugene, Huantes, Sandra, Chudziak, Doreen, Dauber, Katrin, Schaefer, Paul, Scharman, Carlton, Shimada, Hiroyuki, Shojaee, Seyedmehdi, Klemm, Lars, Parameswaran, Reshmi, Loh, Mignon, Kang, Eun-Suk, Koo, Hong Hoe, Hofmann, Wolf-Karsten, Andrade, Jacob, Crooks, Gay M., Willman, Cheryl L., Müschen, Markus, Papayannopoulou, Thalia, Heisterkamp, Nora, Bönig, Halvard, Kim, Yong-Mi

“…Bone marrow (BM) provides chemoprotection for acute lymphoblastic leukemia (ALL) cells, contributing to lack of efficacy of current therapies. Integrin alpha4…”
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Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia by Park, Eugene, Gang, Eun Ji, Hsieh, Yao-Te, Schaefer, Paul, Chae, Sanna, Klemm, Lars, Huantes, Sandra, Loh, Mignon, Conway, Edward M., Kang, Eun-Suk, Hoe Koo, Hong, Hofmann, Wolf-Karsten, Heisterkamp, Nora, Pelus, Louis, Keerthivasan, Ganesan, Crispino, John, Kahn, Michael, Müschen, Markus, Kim, Yong-Mi

“…Relapse of drug-resistant acute lymphoblastic leukemia (ALL) has been associated with increased expression of survivin/BIRC5, an inhibitor of apoptosis…”
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The B Cell Mutator AID Promotes B Lymphoid Blast Crisis and Drug Resistance in Chronic Myeloid Leukemia by Klemm, Lars, Duy, Cihangir, Iacobucci, Ilaria, Kuchen, Stefan, von Levetzow, Gregor, Feldhahn, Niklas, Henke, Nadine, Li, Zhiyu, Hoffmann, Thomas K., Kim, Yong-mi, Hofmann, Wolf-Karsten, Jumaa, Hassan, Groffen, John, Heisterkamp, Nora, Martinelli, Giovanni, Lieber, Michael R., Casellas, Rafael, Müschen, Markus

“…Chronic myeloid leukemia (CML) is induced by BCR-ABL1 and can be effectively treated for many years with Imatinib until leukemia cells acquire drug resistance…”
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Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function by Trageser, Daniel, Iacobucci, Ilaria, Nahar, Rahul, Duy, Cihangir, von Levetzow, Gregor, Klemm, Lars, Park, Eugene, Schuh, Wolfgang, Gruber, Tanja, Herzog, Sebastian, Kim, Yong-mi, Hofmann, Wolf-Karsten, Li, Aihong, Storlazzi, Clelia Tiziana, Jäck, Hans-Martin, Groffen, John, Martinelli, Giovanni, Heisterkamp, Nora, Jumaa, Hassan, Müschen, Markus

“…B cell lineage acute lymphoblastic leukemia (ALL) arises in virtually all cases from B cell precursors that are arrested at pre-B cell receptor-dependent…”
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BCL6 is critical for the development of a diverse primary B cell repertoire by Duy, Cihangir, Yu, J Jessica, Nahar, Rahul, Swaminathan, Srividya, Kweon, Soo-Mi, Polo, Jose M, Valls, Ester, Klemm, Lars, Shojaee, Seyedmehdi, Cerchietti, Leandro, Schuh, Wolfgang, Jäck, Hans-Martin, Hurtz, Christian, Ramezani-Rad, Parham, Herzog, Sebastian, Jumaa, Hassan, Koeffler, H Phillip, de Alborán, Ignacio Moreno, Melnick, Ari M, Ye, B Hilda, Müschen, Markus

“…BCL6 protects germinal center (GC) B cells against DNA damage-induced apoptosis during somatic hypermutation and class-switch recombination. Although…”
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Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia by Gang, Eun Ji, Kim, Hye Na, Hsieh, Yao-Te, Ruan, Yongsheng, Ogana, Heather A., Lee, Solomon, Pham, Jennifer, Geng, Huimin, Park, Eugene, Klemm, Lars, Willman, Cheryl L., Carroll, William L., Mittelman, Steven D., Orgel, Etan, Oberley, Matthew J., Parekh, Chintan, Abdel-Azim, Hisham, Bhojwani, Deepa, Wayne, Alan S., De Arcangelis, Adèle, Georges-Labouesse, Elisabeth, Wayner, Elizabeth, Bonig, Halvard, Minasyan, Aspram, ten Hoeve, Johanna, Graeber, Thomas G., Müschen, Markus, Heisterkamp, Nora, Kim, Yong-Mi

“…Resistance to multimodal chemotherapy continues to limit the prognosis of acute lymphoblastic leukemia (ALL). This occurs in part through a process called…”
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CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies by Lee, Jae-Woong, Geng, Huimin, Chen, Zhengshan, Klemm, Lars, Cosgun, Kadriye Nehir, Xiao, Gang, Masouleh, Behzad, Hurtz, Christian, Parekh, Samir, Kornblau, Steven M., Melnick, Ari, Abbas, Abul, Paietta, Elisabeth, Müschen, Markus

“…Background and hypothesis: B cells critically depend on continuous survival and proliferation signals from a functional B cell receptor (BCR). In >50% of B…”
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Both CpG Methylation and Activation-Induced Deaminase Are Required for the Fragility of the Human bcl-2 Major Breakpoint Region: Implications for the Timing of the Breaks in the t(14;18) Translocation by Cui, Xiaoping, Lu, Zhengfei, Kurosawa, Aya, Klemm, Lars, Bagshaw, Andrew T., Tsai, Albert G., Gemmell, Neil, Müschen, Markus, Adachi, Noritaka, Hsieh, Chih-Lin, Lieber, Michael R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally by Huang, Huilin, Weng, Hengyou, Zhou, Keren, Wu, Tong, Zhao, Boxuan Simen, Sun, Mingli, Chen, Zhenhua, Deng, Xiaolan, Xiao, Gang, Auer, Franziska, Klemm, Lars, Wu, Huizhe, Zuo, Zhixiang, Qin, Xi, Dong, Yunzhu, Zhou, Yile, Qin, Hanjun, Tao, Shu, Du, Juan, Liu, Jun, Lu, Zhike, Yin, Hang, Mesquita, Ana, Yuan, Celvie L., Hu, Yueh-Chiang, Sun, Wenju, Su, Rui, Dong, Lei, Shen, Chao, Li, Chenying, Qing, Ying, Jiang, Xi, Wu, Xiwei, Sun, Miao, Guan, Jun-Lin, Qu, Lianghu, Wei, Minjie, Müschen, Markus, Huang, Gang, He, Chuan, Yang, Jianhua, Chen, Jianjun

“…DNA and histone modifications have notable effects on gene expression 1 . Being the most prevalent internal modification in mRNA, the N 6 -methyladenosine (m 6…”
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AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine by Tsai, Chiou-Tsun, Yang, Pei-Ming, Chern, Ting-Rong, Chuang, Shu-Hui, Lin, Jung-Hsin, Klemm, Lars, Müschen, Markus, Chen, Ching-Chow

“…Activation-induced cytidine deaminase (AID) was originally identified as an inducer of somatic hypermutation (SHM) and class switch recombination (CSR) in…”
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Separation of B- and T-Cell-Specific Signaling Molecules Prevents Oncogenic Transformation in Lymphoid Malignancies by Ketzer, Franz, Klemm, Lars, Robinson, Mark E, Loucks, Christian, Arce, David Fonseca, Cosgun, Kadriye Nehir, Kothari, Shalin, Müschen, Markus

“…Background and significance: Despite the highly homologous structure and function of proteins controlling signal transduction from the BCR and TCR, B- and…”
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B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies by Xiao, Gang, Chan, Lai N., Klemm, Lars, Braas, Daniel, Chen, Zhengshan, Geng, Huimin, Zhang, Qiuyi Chen, Aghajanirefah, Ali, Cosgun, Kadriye Nehir, Sadras, Teresa, Lee, Jaewoong, Mirzapoiazova, Tamara, Salgia, Ravi, Ernst, Thomas, Hochhaus, Andreas, Jumaa, Hassan, Jiang, Xiaoyan, Weinstock, David M., Graeber, Thomas G., Müschen, Markus

“…B cell activation during normal immune responses and oncogenic transformation impose increased metabolic demands on B cells and their ability to retain redox…”
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Genetic Knockin Approaches to Reconstructing DLBCL-Subtypes from Human Germinal Center B-Cells by Khanduja, Dhruv, Robinson, Mark E, Arce, David Fonseca, Klemm, Lars, Leveille, Etienne, Kothari, Shalin, Caeser, Rebecca, Hodson, Daniel James, Müschen, Markus

“…Background and Significance: The clinical and genetic heterogeneity of DLBCL has led to the recent classification of the disease into five genetically distinct…”
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Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies by Kume, Kohei, Chen, Zhengshan, Chan, Lai N., Robinson, Mark E., Leveille, Etienne, Lee, Jaewoong, Cosgun, Kadriye Nehir, Fonseca Arce, David, Khanduja, Dhruv, Klemm, Lars, Müschen, Markus

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Dependence of lymphopoiesis on efficient β-catenin degradation by Cosgun, Kadriye, Jumaa, Huda, Robinson, Mark, Klemm, Lars, Oulghazi, Salim, Fonseca-Arce, David, Xu, Liang, Xiao, Gang, Khanduja, Dhruv, Chan, Lai, Lee, Jaewoong, Kume, Kohei, Song, Joo, Chan, Wing-Chung, Chen, Jianjun, Taketo, Mark, Kothari, Shalin

“…Abstract Wnt/β-catenin pathway is tightly controlled by β-catenin destruction complex to regulate lineage specification and differentiation. Compared to…”
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IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells by Lee, Jaewoong, Robinson, Mark E., Ma, Ning, Artadji, Dewan, Ahmed, Mohamed A., Xiao, Gang, Sadras, Teresa, Deb, Gauri, Winchester, Janet, Cosgun, Kadriye Nehir, Geng, Huimin, Chan, Lai N., Kume, Kohei, Miettinen, Teemu P., Zhang, Ye, Nix, Matthew A., Klemm, Lars, Chen, Chun Wei, Chen, Jianjun, Khairnar, Vishal, Wiita, Arun P., Thomas-Tikhonenko, Andrei, Farzan, Michael, Jung, Jae U., Weinstock, David M., Manalis, Scott R., Diamond, Michael S., Vaidehi, Nagarajan, Müschen, Markus

“…Interferon-induced transmembrane protein 3 (IFITM3) has previously been identified as an endosomal protein that blocks viral infection 1 – 3 . Here we studied…”
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Targeting Unique Synthetic Lethal Interactions between PI3K and MYC in B-ALL by Xiao, Gang, Kume, Kohei, Geng, Huimin, Han, Than Than, Klemm, Lars, Müschen, Markus

“…Significance: Activating mutations of PIK3CA and other PI3K subunits are frequent in almost all types of cancer. Likewise, inactivating lesions of PTEN are…”
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CD25 As Feedback Regulator of Oncogenic TCR Signaling in T-Cell Lymphoma by Sun, Ruifeng, Lee, Jaewoong, Wartewig, Tim, Robinson, Mark E., Bigogno, Alberto, Fonseca Arce, David, Mirza, Abu-Sayeef, Takeda, Andrew, Klemm, Lars, Vykunta, Vivasvan, Shy, Brian, Marson, Alexander, Müschen, Markus

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