Search Results - "Klemm, D J"

Cancer Moonshot Data and Technology Team: Enabling a National Learning Healthcare System for Cancer to Unleash the Power of Data by Hsu, ER, Klemm, JD, Kerlavage, AR, Kusnezov, D, Kibbe, WA

“…The Cancer Moonshot emphasizes the need to learn from the experiences of cancer patients to positively impact their outcomes, experiences, and qualities of…”
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Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy by Rosenwasser, L J, Klemm, D J, Dresback, J K, Inamura, H, Mascali, J J, Klinnert, M, Borish, L

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Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation by WADZINSKI, B. E, WHEAT, W. H, JASPERS, S, PERUSKI, L. F, LICKTEIG, R. L, JOHNSON, G. L, KLEMM, D. J

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Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules by Klemm, J D, Rould, M A, Aurora, R, Herr, W, Pabo, C O

“…The structure of an Oct-1 POU domain-octamer DNA complex has been solved at 3.0 A resolution. The POU-specific domain contacts the 5' half of this site…”
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Oct-1 POU domain-DNA interactions: cooperative binding of isolated subdomains and effects of covalent linkage by Klemm, J D, Pabo, C O

“…Structural and biochemical studies of Oct-1 POU domain-DNA interactions have raised important questions about cooperativity and the role of the linker…”
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The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP) by PARK, E. A, ROESLER, W. J, JINSONG LIU, KLEMM, D. J, GURNEY, A. L, THATCHER, J. D, SHUMAN, J, FRIEDMAN, A, HANSON, R. W

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CREB Activation Induces Adipogenesis in 3T3-L1 Cells by Reusch, Jane E. B., Colton, Lilliester A., Klemm, Dwight J.

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High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids by Strickland, I, Kisich, K, Hauk, P J, Vottero, A, Chrousos, G P, Klemm, D J, Leung, D Y

“…Neutrophils are markedly less sensitive to glucocorticoids than T cells, making it difficult to control inflammation in neutrophil-mediated diseases…”
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Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation by Klemm, D J, Leitner, J W, Watson, P, Nesterova, A, Reusch, J E, Goalstone, M L, Draznin, B

“…Insulin is a potent adipogenic hormone that triggers an induction of a series of transcription factors governing differentiation of pre-adipocytes into mature…”
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Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation by Wheat, W H, Roesler, W J, Klemm, D J

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Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta by Leung, D Y, Hamid, Q, Vottero, A, Szefler, S J, Surs, W, Minshall, E, Chrousos, G P, Klemm, D J

“…In many chronic inflammatory disorders, glucocorticoid (GC) insensitivity is a challenging clinical problem associated with life-threatening disease…”
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The effects of macroinvertebrate taxonomic resolution in large landscape bioassessments: an example from the Mid-Atlantic Highlands, U.S.A by Waite, Ian R., Herlihy, Alan T., Larsen, David P., Urquhart, N. Scott, Klemm, Donald J.

“…Summary 1. During late spring 1993–1995, the U.S. Environmental Protection Agency's Environmental Monitoring and Assessment Program (EMAP) sampled 490 wadeable…”
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DIMERIZATION AS A REGULATORY MECHANISM IN SIGNAL TRANSDUCTION by Klemm, Juli D, Schreiber, Stuart L, Crabtree, Gerald R

“…Dynamic protein-protein interactions are a key component of biological regulatory networks. Dimerization events-physical interactions between related…”
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Development and evaluation of a Macroinvertebrate Biotic Integrity Index (MBII) for regionally assessing Mid-Atlantic Highlands streams by KLEMM, Donald J, BLOCKSOM, Karen A, DAVIS, Wayne S, FULK, Florence A, HERLIHY, Alan T, HUGHES, Robert M, KAUFMANN, Philip R, PECK, David V, STODDARD, John L, THOENY, William T, GRIFFITH, Michael B

“…The Macroinvertebrate Biotic Integrity Index (MBII) was developed from data collected at 574 wadeable stream reaches in the Mid-Atlantic Highlands region…”
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cAMP Response Element-binding Protein Content Is a Molecular Determinant of Smooth Muscle Cell Proliferation and Migration by Klemm, Dwight J., Watson, Peter A., Frid, Maria G., Dempsey, Edward C., Schaack, Jerome, Colton, Lillester A., Nesterova, Albina, Stenmark, Kurt R., Reusch, Jane E.-B.

“…We hypothesized that cAMP response element-binding protein (CREB) could function as a molecular determinant of smooth muscle cell fate. In arterial sections…”
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Purification and properties of protoporphyrinogen oxidase from an anaerobic bacterium, Desulfovibrio gigas by KLEMM, D. J, BARTON, L. L

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X-ray Structure of the GCN4 Leucine Zipper, a Two-Stranded, Parallel Coiled Coil by O'Shea, Erin K., Klemm, Juli D., Kim, Peter S., Alber, Tom

“…The x-ray crystal structure of a peptide corresponding to the leucine zipper of the yeast transcriptional activator GCN4 has been determined at 1.8 angstrom…”
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Inhibition of cAMP-response Element-binding Protein Activity Decreases Protein Kinase B/Akt Expression in 3T3-L1 Adipocytes and Induces Apoptosis by Reusch, Jane E B, Klemm, Dwight J

“…White adipose tissue mass is governed by competing processes that control lipid synthesis and storage, the development of new adipocytes, and their survival…”
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Diabetes-related Changes in cAMP Response Element-binding Protein Content Enhance Smooth Muscle Cell Proliferation and Migration by Watson, Peter A., Nesterova, Albina, Burant, Charles F., Klemm, Dwight J., Reusch, Jane E.-B.

“…We hypothesized that diabetes and glucose-induced reactive oxygen species lead to depletion of cAMP response element-binding protein (CREB) content in the…”
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Purification and assay of a phosphatidylglycerol-stimulated protein kinase from murine leukemic cells and its perturbation in response to IL-3 and PMA treatment by Klemm, D J, Elias, L

“…Protein kinase P (PK-P), which has previously been detected from both human and murine leukemic cells, is characterized by distinctive patterns of phospholipid…”
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