Search Results - "Klement, Giannoula Lakka"

Platelets actively sequester angiogenesis regulators by Lakka Klement, Giannoula, Yip, Tai-Tung, Cassiola, Flavia, Kikuchi, Lena, Cervi, David, Podust, Vladimir, Italiano, Joseph E., Wheatley, Erin, Abou-Slaybi, Abdo, Bender, Elise, Almog, Nava, Kieran, Mark W., Folkman, Judah

“…Clinical trials with antiangiogenic agents have not been able to validate plasma or serum levels of angiogenesis regulators as reliable markers of cancer…”
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Metronomic chemotherapy: An attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance by Kareva, Irina, Waxman, David J, Lakka Klement, Giannoula

“…Graphical Abstract…”
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Normal Wound Healing and Tumor Angiogenesis as a Game of Competitive Inhibition by Kareva, Irina, Abou-Slaybi, Abdo, Dodd, Oliver, Dashevsky, Olga, Klement, Giannoula Lakka

“…Both normal wound healing and tumor angiogenesis are mitigated by the sequential, carefully orchestrated release of growth stimulators and inhibitors. These…”
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Gibbs Energy and Gene Expression Combined as a New Technique for Selecting Drug Targets for Inhibiting Specific Protein–Protein Interactions by Rietman, Edward A, Siegelmann, Hava T, Klement, Giannoula Lakka, Tuszynski, Jack A

“…One of the most important aspects of successful cancer therapy is the identification of a target protein for inhibition interaction. Conventionally, this…”
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Center of Cancer Systems Biology Second Annual Workshop―Tumor Metronomics: Timing and Dose Level Dynamics by HAHNFELDT, Philip, HLATKY, Lynn, LAKKA KLEMENT, Giannoula

“…Metronomic chemotherapy, the delivery of doses in a low, regular manner so as to avoid toxic side effects, was introduced over 12 years ago in the face of…”
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Thermodynamic measures of cancer: Gibbs free energy and entropy of protein–protein interactions by Rietman, Edward A., Platig, John, Tuszynski, Jack A., Lakka Klement, Giannoula

“…Thermodynamics is an important driving factor for chemical processes and for life. Earlier work has shown that each cancer has its own molecular signaling…”
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Personalized therapy design for systemic lupus erythematosus based on the analysis of protein-protein interaction networks by Brant, Elizabeth J, Rietman, Edward A, Klement, Giannoula Lakka, Cavaglia, Marco, Tuszynski, Jack A

“…We analyzed protein expression data for Lupus patients, which have been obtained from publicly available databases. A combination of systems biology and…”
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A Systems Biology Analysis of Chronic Lymphocytic Leukemia by Pozzati, Giulia, Zhou, Jinrui, Hazan, Hananel, Klement, Giannoula Lakka, Siegelmann, Hava T., Tuszynski, Jack A., Rietman, Edward A.

“…Whole-genome sequencing has revealed that TP53, NOTCH1, ATM, SF3B1, BIRC3, ABL, NXF1, BCR, and ZAP70 are often mutated in CLL, but not consistently across all…”
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Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology by Pilatova, Katerina, Greplova, Kristina, Demlova, Regina, Bencsikova, Beatrix, Klement, Giannoula Lakka, Zdrazilova-Dubska, Lenka

“…With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4…”
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Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks by Benzekry, Sebastian, Tuszynski, Jack A, Rietman, Edward A, Lakka Klement, Giannoula

“…The ever-increasing expanse of online bioinformatics data is enabling new ways to, not only explore the visualization of these data, but also to apply novel…”
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Editorial: Precision/Personalized Pediatric Oncology and Immune Therapies: Rather Customize Than Randomize by Kýr, Michal, Klement, Giannoula Lakka, Zdrazilova-Dubska, Lenka, Demlova, Regina, Valik, Dalibor, Slaby, Ondrej, Slavc, Irene, Sterba, Jaroslav

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Individualization of Treatment Improves the Survival of Children With High-Risk Solid Tumors: Comparative Patient Series Analysis in a Real-Life Scenario by Kyr, Michal, Polaskova, Kristyna, Kuttnerova, Zuzana, Merta, Tomas, Neradil, Jakub, Berkovcova, Jitka, Horky, Ondrej, Jezova, Marta, Veselska, Renata, Klement, Giannoula Lakka, Valik, Dalibor, Sterba, Jaroslav

“…The individualization of treatment is attractive, especially in children with high-risk cancer. In such a rare and very heterogeneous group of diseases, large…”
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Comprehensive Molecular Profiling for Relapsed/Refractory Pediatric Burkitt Lymphomas-Retrospective Analysis of Three Real-Life Clinical Cases-Addressing Issues on Randomization and Customization at the Bedside by Polaskova, Kristyna, Merta, Tomas, Martincekova, Alexandra, Zapletalova, Danica, Kyr, Michal, Mazanek, Pavel, Krenova, Zdenka, Mudry, Peter, Jezova, Marta, Tuma, Jiri, Skotakova, Jarmila, Cervinkova, Ivana, Valik, Dalibor, Zdrazilova-Dubska, Lenka, Noskova, Hana, Pal, Karol, Slaby, Ondrej, Fabian, Pavel, Kozakova, Sarka, Neradil, Jakub, Veselska, Renata, Kanderova, Veronika, Hrusak, Ondrej, Freiberger, Tomas, Klement, Giannoula Lakka, Sterba, Jaroslav

“…In order to identify reasons for treatment failures when using targeted therapies, we have analyzed the comprehensive molecular profiles of three relapsed,…”
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Addition of platelet concentrate to dermo-epidermal skin graft in deep burn trauma reduces scarring and need for revision surgeries by Prochazka, Vaclav, Klosova, Hana, Stetinsky, Jiri, Gumulec, Jaromir, Vitkova, Katerina, Salounova, Dana, Dvorackova, Jana, Bielnikova, Hana, Klement, Petr, Levakova, Veronika, Ocelka, Tomas, Pavliska, Lubomir, Kovanic, Pavel, Klement, Giannoula Lakka

“…[corrected] Deep skin burn injuries, especially those on the face, hands, feet, genitalia and perineum represent significant therapeutic challenges. Autologous…”
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The toxicity of anti-VEGF agents when coupled with standard chemotherapeutics by Afranie-Sakyi, Jennifer A, Klement, Giannoula Lakka

“…Graphical Abstract…”
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Insulin-like Growth Factor Receptor Inhibition as Maintenance Therapy for Metastatic Ewing Sarcoma by Fassel, Hannah, Tracy, Donald, Louer, Katie, Klement, Giannoula Lakka

“…Despite the advances in oncology, the survival of children with Ewing Sarcoma metastatic at diagnosis continues to be 27% 3-year event-free survival and 34%…”
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Gibbs Free Energy, a Thermodynamic Measure of Protein–Protein Interactions, Correlates with Neurologic Disability by Keegan, Michael, Siegelmann, Hava T., Rietman, Edward A., Klement, Giannoula Lakka, Tuszynski, Jack A.

“…Modern network science has been used to reveal new and often fundamental aspects of brain network organization in physiological as well as pathological…”
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Personalized anticancer therapy selection using molecular landscape topology and thermodynamics by Rietman, Edward A, Scott, Jacob G, Tuszynski, Jack A, Klement, Giannoula Lakka

“…Personalized anticancer therapy requires continuous consolidation of emerging bioinformatics data into meaningful and accurate information streams. The use of…”
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Nontoxic, fiscally responsible, future of oncology: could it be beginning in the Third World? by Klement, Giannoula Lakka, Kamen, Barton A

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Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets by Etulain, Julia, Negrotto, Soledad, Carestia, Agostina, Pozner, Roberto Gabriel, Romaniuk, María Albertina, D'Atri, Lina Paola, Klement, Giannoula Lakka, Schattner, Mirta

“…Acidosis is one of the hallmarks of tissue injury such as trauma, infection, inflammation, and tumour growth. Although platelets participate in the…”
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