Search Results - "Klejch, Tomáš"

Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro by Doleželová, Eva, Klejch, Tomáš, Špaček, Petr, Slapničková, Martina, Guddat, Luke, Hocková, Dana, Zíková, Alena

“…All medically important unicellular protozoans cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their…”
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Selectivity of original C-hexopyranosyl calix[4]arene conjugates towards lectins of different origin by Kašáková, Martina, Malinovská, Lenka, Klejch, Tomáš, Hlaváčková, Martina, Dvořáková, Hana, Fujdiarová, Eva, Rottnerová, Zdeňka, Maťátková, Olga, Lhoták, Pavel, Wimmerová, Michaela, Moravcová, Jitka

“…As a part of ongoing activities towards the design of ligands against pathogenic lectins, a synthesis of original α-C-galacto/α-C-manno/α-C-fucopyranosyl…”
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Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6‑Oxopurine Phosphoribosyltransferases by Klejch, Tomáš, Keough, Dianne T, King, Gordon, Doleželová, Eva, Česnek, Michal, Buděšínský, Miloš, Zíková, Alena, Janeba, Zlatko, Guddat, Luke W, Hocková, Dana

“…Pathogens such as Plasmodium and Trypanosoma spp. are unable to synthesize purine nucleobases. They rely on the salvage of these purines and their nucleosides…”
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Enzymatically stable unsaturated hyaluronan-derived oligosaccharides with selective cytostatic properties by Klejch, Tomáš, Buffa, Radovan, Šimek, Matěj, Nešporová, Kristina, Exnerová, Andrea, Bednařík, Jiří, Brandejsová, Martina, Vágnerová, Hana, Fiala, František, Velebný, Vladimír

“…Hyaluronan, a linear glycosaminoglycan comprising D-N-acetylglucosamine and D-glucuronic acid, is the main component of the extracellular matrix. Its influence…”
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Modified hyaluronic acid with enhanced resistance to degradation by Buffa, Radovan, Klejch, Tomáš, Hermannová, Martina, Hejlová, Lenka, Svozil, Vít, Vágnerová, Hana, Škubalová, Hana, Nešporová, Kristina, Velebný, Vladimír

“…A mild and efficient reduction of negatively charged glucuronate units of hyaluronic acid (HA) into less polar glucose units has not been reported yet…”
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Acyclic nucleoside phosphonates with unnatural nucleobases, favipiravir and allopurinol, designed as potential inhibitors of the human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases by Klejch, Tomáš, Pohl, Radek, Janeba, Zlatko, Sun, Minghan, Keough, Dianne T., Guddat, Luke W., Hocková, Dana

“…Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) is a key enzyme of the purine salvage pathway and its activity is crucial for the survival of…”
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Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation by Klejch, Tomáš, Keough, Dianne T., Chavchich, Marina, Travis, Jye, Skácel, Jan, Pohl, Radek, Janeba, Zlatko, Edstein, Michael D., Avery, Vicky M., Guddat, Luke W., Hocková, Dana

“…Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) is a recognized target for antimalarial chemotherapeutics. It synthesises all of the…”
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