Search Results - "Kleist, Andrew"

Evolution of fold switching in a metamorphic protein by Dishman, Acacia F, Tyler, Robert C, Fox, Jamie C, Kleist, Andrew B, Prehoda, Kenneth E, Babu, M Madan, Peterson, Francis C, Volkman, Brian F

“…Metamorphic proteins switch between different folds, defying the protein folding paradigm. It is unclear how fold switching arises during evolution. With…”
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New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model by Kleist, Andrew B., Getschman, Anthony E., Ziarek, Joshua J., Nevins, Amanda M., Gauthier, Pierre-Arnaud, Chevigné, Andy, Szpakowska, Martyna, Volkman, Brian F.

“…[Display omitted] Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions, and dysregulated CKR signaling underpins numerous…”
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Decoding the chemotactic signal by Thomas, Monica A., Kleist, Andrew B., Volkman, Brian F.

“…From an individual bacterium to the cells that compose the human immune system, cellular chemotaxis plays a fundamental role in allowing cells to navigate,…”
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Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor by Kleist, Andrew B, Jenjak, Shawn, Sente, Andrija, Laskowski, Lauren J, Szpakowska, Martyna, Calkins, Maggie M, Anderson, Emilie I, McNally, Lisa M, Heukers, Raimond, Bobkov, Vladimir, Peterson, Francis C, Thomas, Monica A, Chevigné, Andy, Smit, Martine J, McCorvy, John D, Babu, M Madan, Volkman, Brian F

“…G protein-coupled receptors (GPCRs) recruit β-arrestins to coordinate diverse cellular processes, but the structural dynamics driving this process are poorly…”
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Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation by Ziarek, Joshua J, Kleist, Andrew B, London, Nir, Raveh, Barak, Montpas, Nicolas, Bonneterre, Julien, St-Onge, Geneviève, DiCosmo-Ponticello, Crystal J, Koplinski, Chad A, Roy, Ishan, Stephens, Bryan, Thelen, Sylvia, Veldkamp, Christopher T, Coffman, Frederick D, Cohen, Marion C, Dwinell, Michael B, Thelen, Marcus, Peterson, Francis C, Heveker, Nikolaus, Volkman, Brian F

“…Chemokines orchestrate cell migration for development, immune surveillance, and disease by binding to cell surface heterotrimeric guanine nucleotide-binding…”
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CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk by Baer, Constance, Kimura, Shunsuke, Rana, Mitra S., Kleist, Andrew B., Flerlage, Tim, Feith, David J., Chockley, Peter, Walter, Wencke, Meggendorfer, Manja, Olson, Thomas L., Cheon, HeeJin, Olson, Kristine C., Ratan, Aakrosh, Mueller, Martha-Lena, Foran, James M., Janke, Laura J., Qu, Chunxu, Porter, Shaina N., Pruett-Miller, Shondra M., Kalathur, Ravi C., Haferlach, Claudia, Kern, Wolfgang, Paietta, Elisabeth, Thomas, Paul G., Babu, M. Madan, Loughran, Thomas P., Iacobucci, Ilaria, Haferlach, Torsten, Mullighan, Charles G.

“…Chronic lymphoproliferative disorder of natural killer cells (CLPD-NK) is characterized by clonal expansion of natural killer (NK) cells where the underlying…”
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Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on 13C-methyl methionine labeling of the atypical chemokine receptor ACKR3 by Kleist, Andrew B, Peterson, Francis, Tyler, Robert C, Gustavsson, Martin, Handel, Tracy M, Volkman, Brian F

“…The past decade has witnessed remarkable progress in the determination of G protein-coupled receptor (GPCR) structures, profoundly expanding our understanding…”
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Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia by Umeda, Masayuki, Ma, Jing, Huang, Benjamin J, Hagiwara, Kohei, Westover, Tamara, Abdelhamed, Sherif, Barajas, Juan M, Thomas, Melvin E, Walsh, Michael P, Song, Guangchun, Tian, Liqing, Liu, Yanling, Chen, Xiaolong, Kolekar, Pandurang, Tran, Quang, Foy, Scott G, Maciaszek, Jamie L, Kleist, Andrew B, Leonti, Amanda R, Ju, Bengsheng, Easton, John, Wu, Huiyun, Valentine, Virginia, Valentine, Marcus B, Liu, Yen-Chun, Ries, Rhonda E, Smith, Jenny L, Parganas, Evan, Iacobucci, Ilaria, Hiltenbrand, Ryan, Miller, Jonathan, Myers, Jason R, Rampersaud, Evadnie, Rahbarinia, Delaram, Rusch, Michael, Wu, Gang, Inaba, Hiroto, Wang, Yi-Cheng, Alonzo, Todd A, Downing, James R, Mullighan, Charles G, Pounds, Stanley, Babu, M Madan, Zhang, Jinghui, Rubnitz, Jeffrey E, Meshinchi, Soheil, Ma, Xiaotu, Klco, Jeffery M

“…The genetics of relapsed pediatric acute myeloid leukemia (AML) has yet to be comprehensively defined. Here, we present the spectrum of genomic alterations in…”
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Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR) by Strachan, Ryan T., Sun, Jin-peng, Rominger, David H., Violin, Jonathan D., Ahn, Seungkirl, Rojas Bie Thomsen, Alex, Zhu, Xiao, Kleist, Andrew, Costa, Tommaso, Lefkowitz, Robert J.

“…The concept of “biased agonism” arises from the recognition that the ability of an agonist to induce a receptor-mediated response (i.e. “efficacy”) can differ…”
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Different contributions of chemokine N‐terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3 by Szpakowska, Martyna, Nevins, Amanda M, Meyrath, Max, Rhainds, David, D'huys, Thomas, Guité‐Vinet, François, Dupuis, Nadine, Gauthier, Pierre‐Arnaud, Counson, Manuel, Kleist, Andrew, St‐Onge, Geneviève, Hanson, Julien, Schols, Dominique, Volkman, Brian F, Heveker, Nikolaus, Chevigné, Andy

“…Background and Purpose Chemokines and their receptors form an intricate interaction and signalling network that plays critical roles in various physiological…”
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Conformation Guides Molecular Efficacy in Docking Screens of Activated β‑2 Adrenergic G Protein Coupled Receptor by Weiss, Dahlia R, Ahn, SeungKirl, Sassano, Maria F, Kleist, Andrew, Zhu, Xiao, Strachan, Ryan, Roth, Bryan L, Lefkowitz, Robert J, Shoichet, Brian K

“…A prospective, large library virtual screen against an activated β2-adrenergic receptor (β2AR) structure returned potent agonists to the exclusion of…”
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Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on 13 C-methyl methionine labeling of the atypical chemokine receptor ACKR3 by Kleist, Andrew B, Peterson, Francis, Tyler, Robert C, Gustavsson, Martin, Handel, Tracy M, Volkman, Brian F

“…The past decade has witnessed remarkable progress in the determination of G protein-coupled receptor (GPCR) structures, profoundly expanding our understanding…”
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Integrated Genomic Analysis Identifies UBTF Tandem Duplications As a Subtype-Defining Lesion in Pediatric Acute Myeloid Leukemia by Umeda, Masayuki, Ma, Jing, Huang, Benjamin J., Hagiwara, Kohei, Westover, Tamara, Abdelhamed, Sherif, Barajas, Juan Martin, Thomas, Melvin Edward, Walsh, Michael P, Song, Guangchun, Tian, Liqing, Liu, Yanling, Chen, Xiaolong, Kolekar, Pandurang, Tran, Quang, Foy, Scott, Maciaszek, Jamie L., Kleist, Andrew B, Leonti, Amanda R., Ju, Bensheng, Easton, John, Wu, Huiyun, Valentine, Virginia, Valentine, Marc, Liu, Yen-Chun, Ries, Rhonda E., Smith, Jenny L., Parganas, Evan, Iacobucci, Ilaria, Hiltenbrand, Ryan, Miller, Jonathan, Myers, Jason, Rampersaud, Evadnie, Rahbarinia, Delaram, Rusch, Michael, Wu, Gang, Inaba, Hiroto, Wang, Yi-Cheng, Alonzo, Todd A., Downing, James R., Mullighan, Charles G., Pounds, Stanley B, Babu, M. Madan, Zhang, Jinghui, Rubnitz, Jeffrey E., Meshinchi, Soheil, Ma, Xiaotu, Klco, Jeffery M.

“…Children with acute myeloid leukemia (AML) have a dismal prognosis due to a high relapse rate; however, the molecular basis leading to relapsed pediatric AML…”
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Poster: CLL-156: Novel CCL22 Mutations Drive Chronic Lymphoproliferative Disorder of NK Cells Through Biased GPCR Signaling by Kimura, Shunsuke, Baer, Constance, Rana, Mitra S, Kleist, Andrew, Feith, David J., Walter, Wencke, Meggendorfer, Manja, Olson, Thomas L., Cheon, HeeJin, Olson, Kristine C., Ratan, Aakrosh, Mueller, Martha-Lena, Foran, James M., Janke, Laura, Qu, Chunxu, Kalathur, Ravi, Haferlach, Claudia, Kern, Wolfgang, Paietta, Elisabeth, Babu, M. Madan, Loughran, Thomas P., Iacobucci, Ilaria, Haferlach, Torsten, Mullighan, Charles G

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CLL-156: Novel CCL22 Mutations Drive Chronic Lymphoproliferative Disorder of NK Cells Through Biased GPCR Signaling by Kimura, Shunsuke, Baer, Constance, Rana, Mitra S, Kleist, Andrew, Feith, David J., Walter, Wencke, Meggendorfer, Manja, Olson, Thomas L., Cheon, HeeJin, Olson, Kristine C., Ratan, Aakrosh, Mueller, Martha-Lena, Foran, James M., Janke, Laura, Qu, Chunxu, Kalathur, Ravi, Haferlach, Claudia, Kern, Wolfgang, Paietta, Elisabeth, Babu, M. Madan, Loughran, Thomas P., Iacobucci, Ilaria, Haferlach, Torsten, Mullighan, Charles G

“…Chronic lymphoproliferative disorder of natural killer cells (CLPD-NK) is a subset of large granular lymphocyte (LGL) leukemia included as a provisional entity…”
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Signal Discrimination and Signal Transduction at Chemokine G Protein-Coupled Receptors by Kleist, Andrew Blair

“…How do extracellular hormones transmit messages across the cell membrane? Borrowing from information theory, Martin Rodbell devised two major components that…”
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Different contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3 by Szpakowska, Martyna, Nevins, Amanda M, Meyrath, Max Marc Roger, Rhainds, David, D'huys, Thomas, Guité-Vinet, François, Dupuis, Nadine, Gauthier, Pierre-Arnaud, Counson, Manuel, Kleist, Andrew, St-Onge, Geneviève, Hanson, Julien, Schols, Dominique, Volkman, Brian, Heveker, Nikolaus, Chevigné, Andy

“…Background and purpose Chemokines and their receptors form an intricate interaction and signaling network that plays critical roles in various physiological…”
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