Search Results - "Kleinman, K"

Matrigel: From discovery and ECM mimicry to assays and models for cancer research by Benton, Gabriel, Arnaoutova, Irina, George, Jay, Kleinman, Hynda K., Koblinski, Jennifer

“…The basement membrane is an important extracellular matrix that is found in all epithelial and endothelial tissues. It maintains tissue integrity, serves as a…”
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Matrigel: Basement membrane matrix with biological activity by Kleinman, Hynda K., Martin, George R.

“…The basement membrane extracellular matrix contacts epithelial, endothelial, fat and smooth muscle cells. Because this extracellular matrix is so thin, it had…”
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In vitro microtumors provide a physiologically predictive tool for breast cancer therapeutic screening by Benton, Gabriel, DeGray, Gerald, Kleinman, Hynda K, George, Jay, Arnaoutova, Irina

“…Many anti-cancer drugs fail in human trials despite showing efficacy in preclinical models. It is clear that the in vitro assays involving 2D monoculture do…”
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The endothelial cell tube formation assay on basement membrane turns 20: state of the science and the art by Arnaoutova, Irina, George, Jay, Kleinman, Hynda K., Benton, Gabriel

“…It has been more than 20 years since it was first demonstrated that endothelial cells will rapidly form capillary-like structures in vitro when plated on top…”
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Angiotropism, pericytic mimicry and extravascular migratory metastasis: an embryogenesis-derived program of tumor spread by Lugassy, Claire, Kleinman, Hynda K., Vermeulen, Peter B., Barnhill, Raymond L.

“…Intravascular dissemination of tumor cells is the accepted mechanism of cancer metastasis. However, the phenomenon of angiotropism, pericyte mimicry (PM), and…”
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Hematogenous metastasis and tumor dormancy as concepts or dogma? The continuum of vessel co-option and angiotropic extravascular migratory metastasis as an alternative by Lugassy, Claire, Kleinman, Hynda K, Cassoux, Nathalie, Barnhill, Raymond

“…It has been accepted for many years that tumor cells spread the circulation to distant sites. The latency period between treatment and tumor recurrence has…”
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Role of the extracellular matrix in morphogenesis by Kleinman, Hynda K, Philp, Deborah, Hoffman, Matthew P

“…The extracellular matrix is a complex, dynamic and critical component of all tissues. It functions as a scaffold for tissue morphogenesis, provides cues for…”
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Imaging of Angiotropism/Vascular Co-Option in a Murine Model of Brain Melanoma: Implications for Melanoma Progression along Extravascular Pathways by Bentolila, Laurent A., Prakash, Roshini, Mihic-Probst, Daniela, Wadehra, Madhuri, Kleinman, Hynda K., Carmichael, Thomas S., Péault, Bruno, Barnhill, Raymond L., Lugassy, Claire

“…Angiotropism/pericytic mimicry and vascular co-option involve tumor cell interactions with the abluminal vascular surface. These two phenomena may be closely…”
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0.1% RGN-259 (Thymosin ß4) Ophthalmic Solution Promotes Healing and Improves Comfort in Neurotrophic Keratopathy Patients in a Randomized, Placebo-Controlled, Double-Masked Phase III Clinical Trial by Sosne, Gabriel, Kleinman, Hynda K, Springs, Clark, Gross, Robert Hollis, Sung, Jihye, Kang, Shinwook

“…We determined the efficacy and safety of 0.1% RGN-259 ophthalmic solution (containing the regenerative protein thymosin ß4) in promoting the healing of…”
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RGN-259 (thymosin β4) improves clinically important dry eye efficacies in comparison with prescription drugs in a dry eye model by Kim, Chae Eun, Kleinman, Hynda K., Sosne, Gabriel, Ousler, George W, Kim, Kyeongsoon, Kang, Sinwook, Yang, Jaewook

“…This study evaluated the clinical activity of RGN-259 (thymosin β4) in comparison with cyclosporine A (CsA), diquafosol (DQS), and lifitegrast (LFA) in a…”
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Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications by Goldstein, Allan L, Hannappel, Ewald, Sosne, Gabriel, Kleinman, Hynda K

“…Thymosin β(4), a low molecular weight, naturally-occurring peptide plays a vital role in the repair and regeneration of injured cells and tissues. After…”
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Increased initiation and growth of tumor cell lines, cancer stem cells and biopsy material in mice using basement membrane matrix protein (Cultrex or Matrigel) co-injection by Fridman, Rafael, Benton, Gabriel, Aranoutova, Irina, Kleinman, Hynda K, Bonfil, R Daniel

“…This protocol requires 2–4 h and presents a method for injecting tumor cells, cancer stem cells or dispersed biopsy material into subcutaneous or orthotopic…”
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Thymosin β4: potential to treat epidermolysis bullosa and other severe dermal injuries by Yang, Won S., Kang, Shinwook, Sung, Jihye, Kleinman, Hynda K.

“…Thymosin β4 is a naturally-occurring regenerative protein present in almost all cells and body fluids, including wound fluid. In multiple preclinical injury…”
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Safety and potential efficacy of gemfibrozil as a supportive treatment for children with late infantile neuronal ceroid lipofuscinosis and other lipid storage disorders by Kim, Kyeongsoon, Kleinman, Hynda K, Lee, Hahn-Jun, Pahan, Kalipada

“…Neuronal Ceroid Lipofuscinosis (NCL), also known as Batten disease, is a group of genetically distinct lysosomal disorders that mainly affect the central…”
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Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation by Chen, Silvia S, Fitzgerald, Wendy, Zimmerberg, Joshua, Kleinman, Hynda K, Margolis, Leonid

“…Cell interactions with the extracellular matrix (ECM) play a critical role in their physiology. Here, we sought to determine the role of exogenous and…”
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The basement membrane matrix in malignancy by Engbring, Jean A, Kleinman, Hynda K

“…Cancer is the second most common cause of death among Americans, although for several age groups it ranks first. Most of these deaths are not due to the…”
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Maternal Fish Consumption, Hair Mercury, and Infant Cognition in a U.S. Cohort by Oken, Emily, Wright, Robert O., Kleinman, Ken P., Bellinger, David, Amarasiriwardena, Chitra J., Hu, Howard, Rich-Edwards, Janet W., Gillman, Matthew W.

“…Fish and other seafood may contain organic mercury but also beneficial nutrients such as n-3 polyunsaturated fatty acids. We endeavored to study whether…”
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A Generalized Linear Mixed Models Approach for Detecting Incident Clusters of Disease in Small Areas, with an Application to Biological Terrorism by Kleinman, Ken, Lazarus, Ross, Platt, Richard

“…Since the intentional dissemination of anthrax through the US postal system in the fall of 2001, there has been increased interest in surveillance for…”
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Bone marrow changes in adolescent girls with anorexia nervosa by Ecklund, Kirsten, Vajapeyam, Sridhar, Feldman, Henry A, Buzney, Catherine D, Mulkern, Robert V, Kleinman, Paul K, Rosen, Clifford J, Gordon, Catherine M

“…Early osteoporosis is common among adolescent girls with anorexia nervosa (AN) and may result from premature conversion of red (RM) to yellow bone marrow. We…”
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Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors by Movafagh, Sharareh, Hobson, John P, Spiegel, Sarah, Kleinman, Hynda K, Zukowska, Zofia

“…Previously we discovered that NPY induces ischemic angiogenesis by activating Y2 and Y5 receptors. The receptors that mediate specific steps of the complex…”
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