Search Results - "Kleinman, JE"

Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophrenia by Vawter, Marquis P, Shannon Weickert, Cynthia, Ferran, Erick, Matsumoto, Mitsuyuki, Overman, Kevin, Hyde, Thomas M, Weinberger, Daniel R, Bunney, William E, Kleinman, Joel E

“…Microarray expression studies have reported decreased mRNA expression of histidine triad nucleotide-binding protein (HINT1) and cytosolic malate dehydrogenase…”
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Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase ( COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain by Chen, Jingshan, Lipska, Barbara K., Halim, Nader, Ma, Quang D., Matsumoto, Mitsuyuki, Melhem, Samer, Kolachana, Bhaskar S., Hyde, Thomas M., Herman, Mary M., Apud, Jose, Egan, Michael F., Kleinman, Joel E., Weinberger, Daniel R.

“…Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the prefrontal cortex of the human brain. Genetic variation in the COMT…”
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RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder by Akula, N, Barb, J, Jiang, X, Wendland, J R, Choi, K H, Sen, S K, Hou, L, Chen, D T W, Laje, G, Johnson, K, Lipska, B K, Kleinman, J E, Corrada-Bravo, H, Detera-Wadleigh, S, Munson, P J, McMahon, F J

“…RNA-sequencing (RNA-seq) is a powerful technique to investigate the complexity of gene expression in the human brain. We used RNA-seq to survey the brain…”
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Neuregulin 1 Transcripts Are Differentially Expressed in Schizophrenia and Regulated by 5' SNPs Associated with the Disease by Law, Amanda J., Lipska, Barbara K., Weickert, Cynthia Shannon, Hyde, Thomas M., Straub, Richard E., Hashimoto, Ryota, Harrison, Paul J., Kleinman, Joel E., Weinberger, Daniel R.

“…Genetic variation in neuregulin 1 (NRG1) is associated with schizophrenia. The disease-associated SNPs are noncoding, and their functional implications remain…”
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Critical Factors in Gene Expression in Postmortem Human Brain: Focus on Studies in Schizophrenia by Lipska, Barbara K., Deep-Soboslay, Amy, Weickert, Cynthia Shannon, Hyde, Thomas M., Martin, Catherine E., Herman, Mary M., Kleinman, Joel E.

“…Studies of postmortem human brain are important for investigating underlying pathogenic molecular mechanisms of neuropsychiatric disorders. They are, however,…”
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Allelic variation in GAD1 (GAD ) is associated with schizophrenia and influences cortical function and gene expression by STRAUB, R. E, LIPSKA, B. K, EGAN, M. F, GOLDBERG, T. E, CALLICOTT, J. H, MAYHEW, M. B, VAKKALANKA, R. K, KOLACHANA, B. S, KLEINMAN, J. E, WEINBERGER, D. R

“…Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the…”
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Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia by WEICKERT, C. S, HYDE, T. M, LIPSKA, B. K, HERMAN, M. M, WEINBERGER, D. R, KLEINMAN, J. E

“…Anatomical and molecular abnormalities of excitatory neurons in the dorsolateral prefrontal cortex (DLPFC) are found in schizophrenia. We hypothesized that…”
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Promoter specific alterations of brain-derived neurotrophic factor mRNA in schizophrenia by Wong, J, Hyde, T.M, Cassano, H.L, Deep-Soboslay, A, Kleinman, J.E, Weickert, C. Shannon

“…Abstract The brain-derived neurotrophic factor (BDNF) gene contains multiple 5′ promoters which generate alternate transcripts. Previously, we found that…”
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Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness by Perlman, William R., Webster, Maree J., Kleinman, Joel E., Weickert, Cynthia Shannon

“…The amygdala is a limbic structure involved in the stress response and the regulation of emotional behaviors, both of which are disrupted in patients with…”
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Catechol-O-Methyltransferase Genotype and Dopamine Regulation in the Human Brain by Akil, Mayada, Kolachana, Bhaskar S, Rothmond, Debora A, Hyde, Thomas M, Weinberger, Daniel R, Kleinman, Joel E

“…A functional polymorphism in the gene for catechol-O-methyltransferase (COMT) has been shown to affect executive cognition and the physiology of the prefrontal…”
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Variation in GRM3 Affects Cognition, Prefrontal Glutamate, and Risk for Schizophrenia by Egan, Michael F., Straub, Richard E., Goldberg, Terry E., Yakub, Imtiaz, Callicott, Joseph H., Hariri, Ahmad R., Mattay, Venkata S., Bertolino, Alessandro, Hyde, Thomas M., Shannon-Weickert, Cynthia, Akil, Mayada, Crook, Jeremy, Vakkalanka, Radha Krishna, Balkissoon, Rishi, Gibbs, Richard A., Kleinman, Joel E., Weinberger, Daniel R., Mishkin, Mortimer

“…GRM3, a metabotropic glutamate receptor-modulating synaptic glutamate, is a promising schizophrenia candidate gene. In a family-based association study, a…”
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Catechol-o-Methyltransferase Enzyme Activity and Protein Expression in Human Prefrontal Cortex across the Postnatal Lifespan by Tunbridge, EM, Weickert, CS, Kleinman, JE, Herman, MM, Chen, J, Kolachana, BS, Harrison, PJ, Weinberger, DR

“…The prefrontal cortex (PFC) dopamine system, which is critical for modulating PFC function, undergoes remodeling until at least young adulthood in primates…”
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Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia by Webster, M.J., O’Grady, J., Kleinman, J.E., Weickert, C.S.

“…Recent studies have shown a decrease in glial number and glial fibrillary acidic protein (GFAP) levels in the frontal and cingulate cortices of individuals…”
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Real-time remote monitoring of water quality: a review of current applications, and advancements in sensor, telemetry, and computing technologies by Glasgow, Howard B, Burkholder, JoAnn M, Reed, Robert E, Lewitus, Alan J, Kleinman, Joseph E

“…Recent advances in communication and sensor technology have catalyzed progress in remote monitoring capabilities for water quality. As a result, the ability to…”
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Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia by HASHIMOTO, R, STRAUB, R. E, WEICKERT, C. S, HYDE, T. M, KLEINMAN, J. E, WEINBERGER, D. R

“…Genetic linkage and association have implicated neuregulin-1 (NRG-1) as a schizophrenia susceptibility gene. We measured mRNA expression levels of the three…”
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Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype by Conejero-Goldberg, C, Hyde, T M, Chen, S, Dreses-Werringloer, U, Herman, M M, Kleinman, J E, Davies, P, Goldberg, T E

“…Alzheimer's disease (AD) is a neurodegenerative condition characterized histopathologically by neuritic plaques and neurofibrillary tangles. The objective of…”
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Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function by Matsumoto, M., Weickert, C.Shannon, Akil, M., Lipska, B.K., Hyde, T.M., Herman, M.M., Kleinman, J.E., Weinberger, D.R.

“…Catechol O-methyltransferase (COMT) is involved in the inactivation of catecholamines, including the neurotransmitter dopamine. A Val 108/158 Met functional…”
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Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs by Lipska, Barbara K., Peters, Tricia, Hyde, Thomas M., Halim, Nader, Horowitz, Cara, Mitkus, Shruti, Weickert, Cynthia Shannon, Matsumoto, Mitsuyuki, Sawa, Akira, Straub, Richard E., Vakkalanka, Radhakrishna, Herman, Mary M., Weinberger, Daniel R., Kleinman, Joel E.

“…DISC1 has been identified as a schizophrenia susceptibility gene based on linkage and SNP association studies and clinical data suggesting that risk SNPs…”
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Autoradiographic characterization of neurotensin receptors in the entorhinal cortex of schizophrenic patients and control subjects by WOLF, S. S, HYDE, T. M, SAUNDERS, R. C, HERMAN, M. M, WEINBERGER, D. R, KLEINMAN, J. E

“…Neurotensin, an endogenous peptide and putative neurotransmitter, exhibits a wide range of interactions with dopaminergic neurons and displays some actions…”
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BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan by Webster, M.J., Herman, M.M., Kleinman, J.E., Shannon Weickert, C.

“…Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (trkB) influence neuronal survival, differentiation, synaptogenesis, and…”
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