Search Results - "Kleinman, J. E."

APOE2 enhances neuroprotection against Alzheimer’s disease through multiple molecular mechanisms by Conejero-Goldberg, C, Gomar, J J, Bobes-Bascaran, T, Hyde, T M, Kleinman, J E, Herman, M M, Chen, S, Davies, P, Goldberg, T E

“…The common APOE2 gene variant is neuroprotective against Alzheimer’s disease (AD) and reduces risk by nearly 50%. However, the mechanisms by which APOE2…”
Get full text

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia by Tao, R, Davis, K N, Li, C, Shin, J H, Gao, Y, Jaffe, A E, Gondré-Lewis, M C, Weinberger, D R, Kleinman, J E, Hyde, T M

“…Genetic variations and adverse environmental events in utero or shortly after birth can lead to abnormal brain development and increased risk of schizophrenia…”
Get full text

RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder by Akula, N, Barb, J, Jiang, X, Wendland, J R, Choi, K H, Sen, S K, Hou, L, Chen, D T W, Laje, G, Johnson, K, Lipska, B K, Kleinman, J E, Corrada-Bravo, H, Detera-Wadleigh, S, Munson, P J, McMahon, F J

“…RNA-sequencing (RNA-seq) is a powerful technique to investigate the complexity of gene expression in the human brain. We used RNA-seq to survey the brain…”
Get full text

Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain by Kaalund, S S, Newburn, E N, Ye, T, Tao, R, Li, C, Deep-Soboslay, A, Herman, M M, Hyde, T M, Weinberger, D R, Lipska, B K, Kleinman, J E

“…Dopamine 2 receptor (DRD2) is of major interest to the pathophysiology of schizophrenia (SCZ) both as a target for antipsychotic drug action as well as a…”
Get full text

Altered gene expression in the dorsolateral prefrontal cortex of individuals with schizophrenia by Guillozet-Bongaarts, A L, Hyde, T M, Dalley, R A, Hawrylycz, M J, Henry, A, Hof, P R, Hohmann, J, Jones, A R, Kuan, C L, Royall, J, Shen, E, Swanson, B, Zeng, H, Kleinman, J E

“…The underlying pathology of schizophrenia (SZ) is likely as heterogeneous as its symptomatology. A variety of cortical and subcortical regions, including the…”
Get full text

Allelic variation in GAD1 (GAD ) is associated with schizophrenia and influences cortical function and gene expression by STRAUB, R. E, LIPSKA, B. K, EGAN, M. F, GOLDBERG, T. E, CALLICOTT, J. H, MAYHEW, M. B, VAKKALANKA, R. K, KOLACHANA, B. S, KLEINMAN, J. E, WEINBERGER, D. R

“…Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the…”
Get full text

Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia by WEICKERT, C. S, HYDE, T. M, LIPSKA, B. K, HERMAN, M. M, WEINBERGER, D. R, KLEINMAN, J. E

“…Anatomical and molecular abnormalities of excitatory neurons in the dorsolateral prefrontal cortex (DLPFC) are found in schizophrenia. We hypothesized that…”
Get full text

Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia by HASHIMOTO, R, STRAUB, R. E, WEICKERT, C. S, HYDE, T. M, KLEINMAN, J. E, WEINBERGER, D. R

“…Genetic linkage and association have implicated neuregulin-1 (NRG-1) as a schizophrenia susceptibility gene. We measured mRNA expression levels of the three…”
Get full text

Promoter specific alterations of brain-derived neurotrophic factor mRNA in schizophrenia by Wong, J, Hyde, T.M, Cassano, H.L, Deep-Soboslay, A, Kleinman, J.E, Weickert, C. Shannon

“…Abstract The brain-derived neurotrophic factor (BDNF) gene contains multiple 5′ promoters which generate alternate transcripts. Previously, we found that…”
Get full text

Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression by Kunii, Y, Hyde, T M, Ye, T, Li, C, Kolachana, B, Dickinson, D, Weinberger, D R, Kleinman, J E, Lipska, B K

“…Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32 or PPP1R1B ) has been of interest in schizophrenia owing to its critical…”
Get full text

Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia by Webster, M.J., O’Grady, J., Kleinman, J.E., Weickert, C.S.

“…Recent studies have shown a decrease in glial number and glial fibrillary acidic protein (GFAP) levels in the frontal and cingulate cortices of individuals…”
Get full text

Increased expression of MARCKS in post-mortem brain of violent suicide completers is related to transcription of a long, noncoding, antisense RNA by Punzi, G, Ursini, G, Shin, J H, Kleinman, J E, Hyde, T M, Weinberger, D R

Get full text

Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype by Conejero-Goldberg, C, Hyde, T M, Chen, S, Dreses-Werringloer, U, Herman, M M, Kleinman, J E, Davies, P, Goldberg, T E

“…Alzheimer's disease (AD) is a neurodegenerative condition characterized histopathologically by neuritic plaques and neurofibrillary tangles. The objective of…”
Get full text

Reductions in neurotrophin receptor mRNAs in the prefrontal cortex of patients with schizophrenia by WEICKERT, C. S, LIGONS, D. L, ROMANCZYK, T, UNGARO, G, HYDE, T. M, HERMAN, M. M, WEINBERGER, D. R, KLEINMAN, J. E

“…Patients with schizophrenia have reduced neurotrophin levels in their dorsolateral prefrontal cortex (DLPFC) compared to normal unaffected individuals. The…”
Get full text

Oestrogen Receptor α Localisation in the Prefrontal Cortex of Three Mammalian Species by Montague, D., Weickert, C. S., Tomaskovic-Crook, E., Rothmond, D. A., Kleinman, J. E., Rubinow, D. R.

“…Oestrogen modulates cognitive function and affective behaviours subserved by the prefrontal cortex (PFC). Identifying and localising oestrogen receptor (ER)α,…”
Get full text

Postnatal alterations in dopaminergic markers in the human prefrontal cortex by Weickert, C.S, Webster, M.J, Gondipalli, P, Rothmond, D, Fatula, R.J, Herman, M.M, Kleinman, J.E, Akil, M

“…Abstract Dopamine in the prefrontal cortex plays a critical role in normal cognition throughout the lifespan and has been implicated in the pathophysiology of…”
Get full text

Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain by Law, A.J, Shannon Weickert, C, Hyde, T.M, Kleinman, J.E, Harrison, P.J

“…Neuregulin-1 (NRG-1) plays important roles in the development and plasticity of the brain, and it has recently been identified as a susceptibility gene for…”
Get full text

Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia by VAWTER, M. P, THATCHER, L, USEN, N, HYDE, T. M, KLEINMAN, J. E, FREED, W. J

“…Several studies suggest that decreased expression of presynaptic proteins may be characteristic of schizophrenia. We examined one such protein, synapsin, in…”
Get full text

Genetic neuropathology of obsessive psychiatric syndromes by Jaffe, A E, Deep-Soboslay, A, Tao, R, Hauptman, D T, Kaye, W H, Arango, V, Weinberger, D R, Hyde, T M, Kleinman, J E

“…Anorexia nervosa (AN), bulimia nervosa (BN) and obsessive-compulsive disorder (OCD) are complex psychiatric disorders with shared obsessive features, thought…”
Get full text

Catechol-o-Methyltransferase Enzyme Activity and Protein Expression in Human Prefrontal Cortex across the Postnatal Lifespan by Tunbridge, EM, Weickert, CS, Kleinman, JE, Herman, MM, Chen, J, Kolachana, BS, Harrison, PJ, Weinberger, DR

“…The prefrontal cortex (PFC) dopamine system, which is critical for modulating PFC function, undergoes remodeling until at least young adulthood in primates…”
Get full text