Search Results - "Kleinert, Hollis D"

Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects by MENARD, J, BOGER, R. S, MOYSE, D. M, GUYENE, T. T, GLASSMAN, H. N, KLEINERT, H. D

“…Zankiren HCl (A-72517) is a potent renin inhibitor shown to have substantial bioavailability in several animal species and to produce dose-related reductions…”
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Renin inhibitors. Dipeptide analogs of angiotensinogen utilizing a structurally modified phenylalanine residue to impart proteolytic stability by Plattner, Jacob J, Marcotte, Patrick A, Kleinert, Hollis D, Stein, Herman H, Greer, Jonathan, Bolis, Giorgio, Fung, Anthony K. L, Bopp, Barbara A, Luly, Jay R

“…A series of renin inhibitors have been prepared and evaluated for their susceptibility to cleavage by the serine protease chymotrypsin. The compounds were…”
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Discovery of a Peptide-Based Renin Inhibitor with Oral Bioavailability and Efficacy by Kleinert, Hollis D., Rosenberg, Saul H., Baker, William R., Stein, Herman H., Klinghofer, Vered, Barlow, Jennifer, Spina, Kenneth, Polakowski, James, Kovar, Peter, Cohen, Jerome, Denissen, Jon

“…Peptidic renin inhibitors have been poorly absorbed across the intestine or rapidly eliminated by the liver and have been reported to have oral…”
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Effects of auriculin (atrial natriuretic factor) on blood pressure, renal function, and the renin-aldosterone system in dogs by Maack, T, Marion, D N, Camargo, M J, Kleinert, H D, Laragh, J H, Vaughan, Jr, E D, Atlas, S A

“…Auriculin is a potent vasoactive and natriuretic peptide that was recently isolated and purified from rat atrial tissue. Since this peptide could be of great…”
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Blood Pressure During Normal Daily Activities, Sleep, and Exercise: Comparison of Values in Normal and Hypertensive Subjects by Pickering, Thomas G, Harshfield, Gregory A, Kleinert, Hollis D, Blank, Seymour, Laragh, John H

“…Blood pressure (BP) readings were taken every 15 minutes using a noninvasive ambulatory BP recorder during 24 hours in 25 subjects with normal BP, 25 with…”
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Atrial Natriuretic Factor Inhibits Angiotensin-, Norepinephrine-, and Potassium-Induced Vascular Contractility by KLEINERT, HOLLIS D, MAACK, THOMAS, ATLAS, STEVEN A, JANUSZEWICZ, ANDRZEJ, SEALEY, JEAN E, LARAGH, JOHN H

“…We have previously shown that the natriuretic effect of rat atrial extract (AE) may be due, perhaps entirely, to its powerful renal hemodynamic actions. The…”
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Low- versus high-dose recombinant urokinase for the treatment of chronic saphenous vein graft occlusion by Teirstein, Paul S, Mann, J.Tift, Cundey, Paul E, Schechter, Eliot, Jacobs, W.Carlisle, Grines, Cindy L, Stagaman, David J, Lansky, Alexandra J, Hultquist, Mitchell A, Kusnick, Barry A, Heuser, Richard R, Kleinert, Hollis D, Popma, Jeffrey

“…Recanalization of a totally occluded saphenous vein graft (SVG) using commercially available urokinase from human kidney cells has been shown to be effective,…”
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What Is the Value of Home Blood Pressure Measurement in Patients with Mild Hypertension? by KLEINERT, HOLLIS D, HARSHFIELD, GREGORY A, PICKERING, THOMAS G, DEVEREUX, RICHARD B, SULLIVAN, PATRICIA A, MARION, ROSE MERIE, MALLORY, WALTER K, LARAGH, JOHN H

“…To investigate the value of home blood pressure (BP) measurements, the BP was recorded daily by the patient at home and compared with recordings in the…”
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Hemodynamic and Humoral Effects of the New Renin Inhibitor Enalkiren in Normal Humans by Delabays, Alain, Nussberger, Jiirg, Porchet, Marinette, Waeber, Bernard, Hoyos, Patricia, Boger, Robert, Glassman, Harriet, Kleinert, Hollis D, Luther, Robert, Brunner, Hans R

“…The effect of the renin inhibitor enalkiren (Abbott- 64662) was evaluated in eight normal volunteer subjects on a standardized sodium diet (100 mmol/day) by…”
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Renin inhibitors. Dipeptide analogs of angiotensinogen utilizing a dihydroxyethylene transition-state mimic at the scissile bond to impart greater inhibitory potency by Luly, Jay R, BaMaung, Nwe, Soderquist, Jeff, Fung, Anthony K. L, Stein, Herman, Kleinert, Hollis D, Marcotte, Patrick A, Egan, David A, Bopp, Barbara

“…The synthesis of diol-containing renin inhibitors has revealed that a simple vicinal diol functionality corresponding to the scissile Leu-Val bond in human…”
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Nonpeptide renin inhibitors employing a novel 3-aza (or oxa)-2,4-dialkyl glutaric acid moiety as a P2/P3 amide bond replacement by Baker, William R, Fung, Anthony K. L, Kleinert, Hollis D, Stein, Herman H, Plattner, Jacob J, Armiger, Yoek Lin, Condon, Stephen L, Cohen, Jerome, Egan, David A

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Effect of Atrial Natriuretic Factor on Blood Pressure, Renin, and Aldosterone in Goldblatt Hypertension by VOLPE, MASSIMO, ODELL, GEOFFREY, KLEINERT, HOLLIS D, MULLER, FRANCO, CAMARGO, MARIA J, LARAGH, JOHN H, MAACK, THOMAS, VAUGHAN, E DARRACOTT, ATLAS, STEVEN A

“…We previously provided evidence that atrial natriuretic factor (ANF) antagonizes angiotensin H-induced vascular contractility and angiotensin H-stimulated…”
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Effects of the Renin Inhibitor A-64662 in Monkeys and Rats with Varying Baseline Plasma Renin Activity by KLEINERT, HOLLIS D, MARTIN, DONALD, CHEKAL, MARCIA A, KADAM, JILL, LULY, JAY R, PLATTNER, JACOB J, PERUN, THOMAS J, LUTHER, ROBERT R

“…The efficacy of the potent, primate selective renin inhibitor A-64662 was studied in monkeys and rats with varying baseline plasma renin activity (PRA) to…”
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Design of a well-absorbed renin inhibitor by Rosenberg, Saul H, Kleinert, Hollis D, Stein, Herman H, Martin, Donald L, Chekal, Marcia A, Cohen, Jerome, Egan, David A, Tricarico, Karen A, Baker, William R

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Discovery of a Well-Absorbed, Efficacious Renin Inhibitor, A-74273 by Kleinert, Hollis D, Stein, Herman H, Boyd, Steven, Fung, Anthony K.L, Baker, William R, Verburg, Kenneth M, Polakowski, James S, Kovar, Peter, Barlow, Jennifer, Cohen, Jerome, Klinghofer, Vered, Mantei, Robert, Cepa, Steven, Rosenberg, Saul, Denissen, Jon F

“…Hie development of orally active renin inhibitors has been plagued by limited bioavailability in animals and humans. A-74273 is a novel, potent nonpeptide…”
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Renin inhibitors. Dipeptide analogs of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond by Bolis, Giorgio, Fung, Anthony K. L, Greer, Jonathan, Kleinert, Hollis D, Marcotte, Patrick A, Perun, Thomas J, Plattner, Jacob J, Stein, Herman H

“…A series of dipeptide analogues of angiotensinogen have been prepared and evaluated for their ability to inhibit the aspartic proteinase renin. The compounds…”
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Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action by Rosenberg, Saul H, Woods, Keith W, Sham, Hing L, Kleinert, Hollis D, Martin, Donald L, Stein, Herman, Cohen, Jerome, Egan, David A, Bopp, Barbara

“…Incorporation of nonreactive polar functionalities at the C- and N-termini of renin inhibitors led to the development of a subnanomolar compound (21) with…”
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Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement by Dellaria, Joseph F, Maki, Robert G, Bopp, Barbara A, Cohen, Jerome, Kleinert, Hollis D, Luly, Jay R, Merits, Ilmar, Plattner, Jacob J, Stein, Herman H

“…Further structure-activity relationships (SAR) for a novel dipeptide series inhibitors are reported. These inhibitors retain the Phe8-His9 portion of…”
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Effects of Chronic Infusion of Renin Inhibitor A-64662 in Sodium-Depleted Monkeys by Verburg, Kenneth M, Kleinert, Hollis D, Kadam, Jill R.C, Chekal, Marcia A, Mento, Peter F, Wilkes, Barry M

“…The potent and primate-selective renin inhibitor A-64662 (n=8) or vehicle (n=6) was administered intravenously for 7 days to sodium-depleted cynomolgus monkeys…”
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Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residue by Rosenberg, Saul H, Woods, Keith W, Kleinert, Hollis D, Stein, Herman, Nellans, Hugh N, Hoffman, Daniel J, Spanton, Stephen G, Pyter, Richard A, Cohen, Jerome

“…Azidomethyl-substituted 1,2- and 1,3-diols were prepared from Boc-cyclohexylalanal and evaluated as transition state analogue renin inhibitors, leading to the…”
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