Search Results - "Kleinedler, James J."

Synergistic effect of resveratrol and quercetin released from drug-eluting polymer coatings for endovascular devices by Kleinedler, James J., Foley, John D., Alexander, J. Steven, Roerig, Sandra C., Hebert, Valeria Y., Dugas, Tammy R.

“…This study describes the development and evaluation of novel polymer films that provide controlled release of two vascular‐protective polyphenols for…”
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Novel nanocomposite stent coating releasing resveratrol and quercetin reduces neointimal hyperplasia and promotes re-endothelialization by Kleinedler, James J., Foley, John D., Orchard, Elysse A., Dugas, Tammy R.

“…Late-term thrombosis associated with drug-eluting stents may be due to the non-selective actions of antimitogenic drugs on endothelial cells, leading to…”
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Resveratrol promotes endothelial cell wound healing under laminar shear stress through an estrogen receptor-α-dependent pathway by Yurdagul, Jr, Arif, Kleinedler, James J, McInnis, Marshall C, Khandelwal, Alok R, Spence, Allyson L, Orr, A Wayne, Dugas, Tammy R

“…Restenosis is an adverse outcome of angioplasty, characterized by vascular smooth muscle cell (VSMC) hyperplasia. However, therapies targeting VSMC…”
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A structure-sensitive continuum model of arterial drug deposition by Saylor, David M., Soneson, Joshua E., Kleinedler, James J., Horner, Marc, Warren, James A.

“…The successful function of drug-eluting devices used in the treatment of atherosclerosis relies on the concentration and retention of the drug in the vessel…”
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Resveratrol and quercetin interact to inhibit neointimal hyperplasia in mice with a carotid injury by Khandelwal, Alok R, Hebert, Valeria Y, Kleinedler, James J, Rogers, Lynette K, Ullevig, Sarah L, Asmis, Reto, Shi, Runhua, Dugas, Tammy R

“…Restenosis is a critical complication of angioplasty and stenting. Restenosis is multifactorial, involving endothelial injury, inflammation, platelet…”
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Antiretrovirals Induce Endothelial Dysfunction via an Oxidant-Dependent Pathway and Promote Neointimal Hyperplasia by Jiang, Bo, Khandelwal, Alok R., Rogers, Lynette K., Hebert, Valeria Y., Kleinedler, James J., Zavecz, James H., Shi, Weibin, Orr, A. Wayne, Dugas, Tammy R.

“…Human immunodeficiency virus-1 antiretroviral treatment is associated with an increased incidence of atherosclerosis. We hypothesized that antiretrovirals…”
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Arterial pharmacokinetics of red wine polyphenols: implications for novel endovascular therapies targeting restenosis by Kleinedler, James J, Pjescic, Ilija, Bullock, Kirby K, Khaliq, Abdul, Foley, John D, Dugas, Tammy R

“…Drug-eluting stents (DESs) are endovascular devices that provide controlled release of compounds to interfere with restenosis, an adverse outcome of…”
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A dietary approach to increase in-stent stenosis and face validity of a rat model for arterial angioplasty and stenting by Kleinedler, James J, Orchard, Elysse A, Foley, John D, Rogers, Lynette K, Hebert, Valeria Y, Dugas, Tammy R

“…Abstract Objective To expedite the investigation of new devices for inhibiting restenosis, we aimed to develop a modified model of arterial angioplasty and…”
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Investigation of polyphenols as novel therapeutics for drug-eluting stents by Kleinedler, James J

“…Drug-eluting stents (DES) provide mechanical support to a vessel after angioplasty, as well as provide controlled release of compounds that interfere with…”
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