Search Results - "Kleinberger, Gernot"

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE by Parhizkar, Samira, Arzberger, Thomas, Brendel, Matthias, Kleinberger, Gernot, Deussing, Maximilian, Focke, Carola, Nuscher, Brigitte, Xiong, Monica, Ghasemigharagoz, Alireza, Katzmarski, Natalie, Krasemann, Susanne, Lichtenthaler, Stefan F., Müller, Stephan A., Colombo, Alessio, Monasor, Laura Sebastian, Tahirovic, Sabina, Herms, Jochen, Willem, Michael, Pettkus, Nadine, Butovsky, Oleg, Bartenstein, Peter, Edbauer, Dieter, Rominger, Axel, Ertürk, Ali, Grathwohl, Stefan A., Neher, Jonas J., Holtzman, David M., Meyer-Luehmann, Melanie, Haass, Christian

“…Coding variants in the triggering receptor expressed on myeloid cells 2 ( TREM2 ) are associated with late-onset Alzheimer’s disease (AD). We demonstrate that…”
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An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function by Schlepckow, Kai, Kleinberger, Gernot, Fukumori, Akio, Feederle, Regina, Lichtenthaler, Stefan F, Steiner, Harald, Haass, Christian

“…Sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) support an essential function of microglia and…”
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TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury by Mazaheri, Fargol, Snaidero, Nicolas, Kleinberger, Gernot, Madore, Charlotte, Daria, Anna, Werner, Georg, Krasemann, Susanne, Capell, Anja, Trümbach, Dietrich, Wurst, Wolfgang, Brunner, Bettina, Bultmann, Sebastian, Tahirovic, Sabina, Kerschensteiner, Martin, Misgeld, Thomas, Butovsky, Oleg, Haass, Christian

“…Sequence variations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to an increased risk for neurodegenerative disorders such…”
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Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury by Suárez-Calvet, Marc, Araque Caballero, Miguel Ángel, Kleinberger, Gernot, Bateman, Randall J, Fagan, Anne M, Morris, John C, Levin, Johannes, Danek, Adrian, Ewers, Michael, Haass, Christian

“…Emerging evidence supports a role for innate immunity and microglia in Alzheimer's disease (AD) pathophysiology. However, no marker related to microglia has…”
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TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance by Xiang, Xianyuan, Werner, Georg, Bohrmann, Bernd, Liesz, Arthur, Mazaheri, Fargol, Capell, Anja, Feederle, Regina, Knuesel, Irene, Kleinberger, Gernot, Haass, Christian

“…Immunotherapeutic approaches are currently the most advanced treatments for Alzheimer's disease (AD). Antibodies against amyloid β‐peptide (Aβ) bind to amyloid…”
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The FTD‐like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism by Kleinberger, Gernot, Brendel, Matthias, Mracsko, Eva, Wefers, Benedikt, Groeneweg, Linda, Xiang, Xianyuan, Focke, Carola, Deußing, Maximilian, Suárez‐Calvet, Marc, Mazaheri, Fargol, Parhizkar, Samira, Pettkus, Nadine, Wurst, Wolfgang, Feederle, Regina, Bartenstein, Peter, Mueggler, Thomas, Arzberger, Thomas, Knuesel, Irene, Rominger, Axel, Haass, Christian

“…Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk for several neurodegenerative diseases including Alzheimer's…”
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Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region by Schlepckow, Kai, Monroe, Kathryn M, Kleinberger, Gernot, Cantuti‐Castelvetri, Ludovico, Parhizkar, Samira, Xia, Dan, Willem, Michael, Werner, Georg, Pettkus, Nadine, Brunner, Bettina, Sülzen, Alice, Nuscher, Brigitte, Hampel, Heike, Xiang, Xianyuan, Feederle, Regina, Tahirovic, Sabina, Park, Joshua I, Prorok, Rachel, Mahon, Cathal, Liang, Chun‐Chi, Shi, Ju, Kim, Do Jin, Sabelström, Hanna, Huang, Fen, Di Paolo, Gilbert, Simons, Mikael, Lewcock, Joseph W, Haass, Christian

“…Triggering receptor expressed on myeloid cells 2 (TREM2) is essential for the transition of homeostatic microglia to a disease‐associated microglial state. To…”
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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration by Wils, Hans, Kleinberger, Gernot, Janssens, Jonathan, Pereson, Sandra, Joris, Geert, Cuijt, Ivy, Smits, Veerle, Ceuterick-de Groote, Chantal, Van Broeckhoven, Christine, Kumar-Singh, Samir

“…Neuronal cytoplasmic and intranuclear aggregates of RNA-binding protein TDP-43 are a hallmark feature of neurodegenerative diseases such as amyotrophic lateral…”
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Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology by Suárez-Calvet, Marc, Morenas-Rodríguez, Estrella, Kleinberger, Gernot, Schlepckow, Kai, Araque Caballero, Miguel Ángel, Franzmeier, Nicolai, Capell, Anja, Fellerer, Katrin, Nuscher, Brigitte, Eren, Erden, Levin, Johannes, Deming, Yuetiva, Piccio, Laura, Karch, Celeste M, Cruchaga, Carlos, Shaw, Leslie M, Trojanowski, John Q, Weiner, Michael, Ewers, Michael, Haass, Christian

“…TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk…”
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sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers by Suárez‐Calvet, Marc, Kleinberger, Gernot, Araque Caballero, Miguel Ángel, Brendel, Matthias, Rominger, Axel, Alcolea, Daniel, Fortea, Juan, Lleó, Alberto, Blesa, Rafael, Gispert, Juan Domingo, Sánchez‐Valle, Raquel, Antonell, Anna, Rami, Lorena, Molinuevo, José L, Brosseron, Frederic, Traschütz, Andreas, Heneka, Michael T, Struyfs, Hanne, Engelborghs, Sebastiaan, Sleegers, Kristel, Van Broeckhoven, Christine, Zetterberg, Henrik, Nellgård, Bengt, Blennow, Kaj, Crispin, Alexander, Ewers, Michael, Haass, Christian

“…TREM2 is an innate immune receptor expressed on the surface of microglia. Loss‐of‐function mutations of TREM2 are associated with increased risk of Alzheimer's…”
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Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons by Riemenschneider, Henrick, Guo, Qiang, Bader, Jakob, Frottin, Frédéric, Farny, Daniel, Kleinberger, Gernot, Haass, Christian, Mann, Matthias, Hartl, F. Ulrich, Baumeister, Wolfgang, Hipp, Mark S, Meissner, Felix, Fernández‐Busnadiego, Rubén, Edbauer, Dieter

“…Aggregation of the multifunctional RNA‐binding protein TDP‐43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and…”
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A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study by Gijselinck, Ilse, PhD, Van Langenhove, Tim, MD, van der Zee, Julie, PhD, Sleegers, Kristel, PhD, Philtjens, Stéphanie, MSc, Kleinberger, Gernot, MSc, Janssens, Jonathan, MSc, Bettens, Karolien, PhD, Van Cauwenberghe, Caroline, MSc, Pereson, Sandra, MSc, Engelborghs, Sebastiaan, Prof, Sieben, Anne, MD, De Jonghe, Peter, Prof, Vandenberghe, Rik, Prof, Santens, Patrick, Prof, De Bleecker, Jan, Prof, Maes, Githa, MSc, Bäumer, Veerle, BSc, Dillen, Lubina, PhD, Joris, Geert, BSc, Cuijt, Ivy, MSc, Corsmit, Ellen, BSc, Elinck, Ellen, MSc, Van Dongen, Jasper, BSc, Vermeulen, Steven, MSc, Van den Broeck, Marleen, BSc, Vaerenberg, Carolien, MSc, Mattheijssens, Maria, BSc, Peeters, Karin, BSc, Robberecht, Wim, Prof, Cras, Patrick, Prof, Martin, Jean-Jacques, Prof, De Deyn, Peter P, Prof, Cruts, Marc, Prof, Van Broeckhoven, Christine, Prof

“…Summary Background Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are extremes of a clinically, pathologically, and…”
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Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study by Brendel, Matthias, Probst, Federico, Jaworska, Anna, Overhoff, Felix, Korzhova, Viktoria, Albert, Nathalie L, Beck, Roswitha, Lindner, Simon, Gildehaus, Franz-Josef, Baumann, Karlheinz, Bartenstein, Peter, Kleinberger, Gernot, Haass, Christian, Herms, Jochen, Rominger, Axel

“…Amyloid imaging by small-animal PET in models of Alzheimer disease (AD) offers the possibility to track amyloidogenesis and brain energy metabolism. Because…”
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Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation by Ewers, Michael, Biechele, Gloria, Suárez‐Calvet, Marc, Sacher, Christian, Blume, Tanja, Morenas‐Rodriguez, Estrella, Deming, Yuetiva, Piccio, Laura, Cruchaga, Carlos, Kleinberger, Gernot, Shaw, Leslie, Trojanowski, John Q, Herms, Jochen, Dichgans, Martin, Brendel, Matthias, Haass, Christian, Franzmeier, Nicolai

“…Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's disease (AD). Both cerebrospinal fluid (CSF) levels of soluble…”
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The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans by Xiang, Xianyuan, Piers, Thomas M, Wefers, Benedikt, Zhu, Kaichuan, Mallach, Anna, Brunner, Bettina, Kleinberger, Gernot, Song, Wilbur, Colonna, Marco, Herms, Jochen, Wurst, Wolfgang, Pocock, Jennifer M, Haass, Christian

“…The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases the risk for late onset Alzheimer's disease. Mouse…”
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Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis by Götzl, Julia K., Mori, Kohji, Damme, Markus, Fellerer, Katrin, Tahirovic, Sabina, Kleinberger, Gernot, Janssens, Jonathan, van der Zee, Julie, Lang, Christina M., Kremmer, Elisabeth, Martin, Jean-Jacques, Engelborghs, Sebastiaan, Kretzschmar, Hans A., Arzberger, Thomas, Van Broeckhoven, Christine, Haass, Christian, Capell, Anja

“…Heterozygous loss-of-function mutations in the progranulin ( GRN ) gene and the resulting reduction of GRN levels is a common genetic cause for frontotemporal…”
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Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism by Götzl, Julia K, Brendel, Matthias, Werner, Georg, Parhizkar, Samira, Sebastian Monasor, Laura, Kleinberger, Gernot, Colombo, Alessio‐Vittorio, Deussing, Maximilian, Wagner, Matias, Winkelmann, Juliane, Diehl‐Schmid, Janine, Levin, Johannes, Fellerer, Katrin, Reifschneider, Anika, Bultmann, Sebastian, Bartenstein, Peter, Rominger, Axel, Tahirovic, Sabina, Smith, Scott T, Madore, Charlotte, Butovsky, Oleg, Capell, Anja, Haass, Christian

“…Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial neurodegenerative phenotype (MGnD) representing two opposite ends. A number of…”
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Mechanisms of Granulin Deficiency: Lessons from Cellular and Animal Models by Kleinberger, Gernot, Capell, Anja, Haass, Christian, Van Broeckhoven, Christine

“…The identification of causative mutations in the (pro)granulin gene ( GRN ) has been a major breakthrough in the research on frontotemporal dementia (FTD). So…”
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Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life Span of Wild-Type Mice: A PET Study by Brendel, Matthias, Focke, Carola, Blume, Tanja, Peters, Finn, Deussing, Maximilian, Probst, Federico, Jaworska, Anna, Overhoff, Felix, Albert, Nathalie, Lindner, Simon, von Ungern-Sternberg, Barbara, Bartenstein, Peter, Haass, Christian, Kleinberger, Gernot, Herms, Jochen, Rominger, Axel

“…Contrary to findings in the human brain, F-FDG PET shows cerebral hypermetabolism of aged wild-type (WT) mice relative to younger animals, supposedly due to…”
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Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk by Ali, Muhammad, Sung, Yun Ju, Wang, Fengxian, Fernández, Maria V, Morris, John C, Fagan, Anne M, Blennow, Kaj, Zetterberg, Henrik, Heslegrave, Amanda, Johansson, Per M, Svensson, Johan, Nellgård, Bengt, Lleó, Alberto, Alcolea, Daniel, Clarimon, Jordi, Rami, Lorena, Molinuevo, José Luis, Suárez-Calvet, Marc, Morenas-Rodríguez, Estrella, Kleinberger, Gernot, Haass, Christian, Ewers, Michael, Levin, Johannes, Farlow, Martin R, Perrin, Richard J, Cruchaga, Carlos

“…Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in…”
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