Search Results - "Klein, William H"

Regulation of lifespan by neural excitation and REST by Zullo, Joseph M., Drake, Derek, Aron, Liviu, O’Hern, Patrick, Dhamne, Sameer C., Davidsohn, Noah, Mao, Chai-An, Klein, William H., Rotenberg, Alexander, Bennett, David A., Church, George M., Colaiácovo, Monica P., Yankner, Bruce A.

“…The mechanisms that extend lifespan in humans are poorly understood. Here we show that extended longevity in humans is associated with a distinct transcriptome…”
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Ret signaling in ureteric bud epithelial cells controls cell movements, cell clustering and bud formation by Packard, Adam, Klein, William H, Costantini, Frank

“…Ret signaling promotes branching morphogenesis during kidney development, but the underlying cellular mechanisms remain unclear. While Ret-expressing…”
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Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases by Moresi, Viviana, Williams, Andrew H., Meadows, Eric, Flynn, Jesse M., Potthoff, Matthew J., McAnally, John, Shelton, John M., Backs, Johannes, Klein, William H., Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.

“…Maintenance of skeletal muscle structure and function requires innervation by motor neurons, such that denervation causes muscle atrophy. We show that…”
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Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis by Kiyama, Takae, Chen, Ching-Kang, Wang, Steven W, Pan, Ping, Ju, Zhenlin, Wang, Jing, Takada, Shinako, Klein, William H, Mao, Chai-An

“…Mitochondrial dysfunction has been implicated in the pathologies of a number of retinal degenerative diseases in both the outer and inner retina. In the outer…”
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LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse by Ehrman, Lisa A, Mu, Xiuqian, Waclaw, Ronald R, Yoshida, Yutaka, Vorhees, Charles V, Klein, William H, Campbell, Kenneth

“…The mammalian striatum controls the output of the basal ganglia via two distinct efferent pathways, the direct (i.e., striatonigral) and the indirect (i.e.,…”
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Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons by Sessa, Alessandro, Mao, Chai-An, Colasante, Gaia, Nini, Alessandro, Klein, William H, Broccoli, Vania

“…Little is known about how, during its formidable expansion in development and evolution, the cerebral cortex is able to maintain the correct balance between…”
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The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis by Joyal, Jean-Sébastien, Rihakova, Lenka, Hardy, Pierre, Cho, Jang-Hyeon, Mitchell, Grant, Zaniolo, Karine, Varma, Daya R, Mu, Xiuqian, Beauséjour, Christian, Sennlaub, Florian, Klein, William H, Lachapelle, Pierre, Mamer, Orval, Leduc, Martin, Chemtob, Sylvain, Di Polo, Adriana, Hamel, David, Kermorvant-Duchemin, Elsa, Sapieha, Przemyslaw, Honoré, Jean-Claude, Tremblay, Sophie, Sirinyan, Mirna, Andelfinger, Gregor

“…The mechanisms that control blood vessel formation are incompletely understood. Sylvain Chemtob and his colleagues now find that blood vessel formation in…”
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Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2 by Mu, Xiuqian, Fu, Xueyao, Beremand, Phillip D, Thomas, Terry L, Klein, William H

“…Understanding gene regulatory networks (GRNs) that control neuronal differentiation will provide systems-level perspectives on neurogenesis. We have previously…”
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Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina by Zhang, Qi, Zagozewski, Jamie, Cheng, Shaohong, Dixit, Rajiv, Zhang, Shunzhen, de Melo, Jimmy, Mu, Xiuqian, Klein, William H, Brown, Nadean L, Wigle, Jeffrey T, Schuurmans, Carol, Eisenstat, David D

“…Regulated retinal ganglion cell (RGC) differentiation and axonal guidance is required for a functional visual system. Homeodomain and basic helix-loop-helix…”
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A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression by Tang, Huibin, Macpherson, Peter, Marvin, Michael, Meadows, Eric, Klein, William H, Yang, Xiang-Jiao, Goldman, Daniel

“…Muscle activity contributes to formation of the neuromuscular junction and affects muscle metabolism and contractile properties through regulated gene…”
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Myogenin Regulates Exercise Capacity and Skeletal Muscle Metabolism in the Adult Mouse by Flynn, Jesse M, Meadows, Eric, Fiorotto, Marta, Klein, William H, Nogales-Gadea, Gisela

“…Although skeletal muscle metabolism is a well-studied physiological process, little is known about how it is regulated at the transcriptional level. The…”
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Canonical Wnt signaling functions in second heart field to promote right ventricular growth by Ai, Di, Fu, Xueyao, Wang, Jun, Lu, Mei-Fang, Chen, Li, Baldini, Antonio, Klein, William H, Martin, James F

“…The second heart field (SHF), progenitor cells that are initially sequestered outside the heart, migrates into the heart and gives rise to endocardium,…”
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Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse by Kiyama, Takae, Long, Ye, Chen, Ching-Kang, Whitaker, Christopher M., Shay, Allison, Wu, Hongyu, Badea, Tudor C., Mohsenin, Amir, Parker-Thornburg, Jan, Klein, William H., Mills, Stephen L., Massey, Stephen C., Mao, Chai-An

“…In the mouse retina, more than 30 retinal ganglion cell (RGC) subtypes have been classified based on a combined metric of morphological and functional…”
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Neurosensory and neuromuscular organization in tube feet of the sea urchin Strongylocentrotus purpuratus by Agca, Cavit, Elhajj, Milad C., Klein, William H., Venuti, Judith M.

“…Several behavioral and electrophysiological studies indicate that all classes of echinoderms, including Echinoidia, the class to which sea urchins belong, are…”
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Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size by Knapp, Jennifer R, Davie, Judith K, Myer, Anita, Meadows, Eric, Olson, Eric N, Klein, William H

“…Although the mechanisms regulating the formation of embryonic skeletal muscle in vertebrates are well characterized, less is known about postnatal muscle…”
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Myogenin regulates exercise capacity but is dispensable for skeletal muscle regeneration in adult mdx mice by Meadows, Eric, Flynn, Jesse M, Klein, William H

“…Duchenne muscular dystrophy (DMD) is the most prevalent inherited childhood muscle disorder in humans. mdx mice exhibit a similar pathophysiology to the human…”
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Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse by Mao, Chai-An, Kiyama, Takae, Pan, Ping, Furuta, Yasuhide, Hadjantonakis, Anna-Katerina, Klein, William H

“…The mechanisms regulating retinal ganglion cell (RGC) development are crucial for retinogenesis and for the establishment of normal vision. However, these…”
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A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate by Mu, Xiuqian, Fu, Xueyao, Sun, Hongxia, Beremand, Phillip D., Thomas, Terry L., Klein, William H.

“…Math5, a mouse homolog of the Drosophila proneural bHLH transcription factor Atonal, is essential in the developing retina to establish retinal progenitor cell…”
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Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5 by Mao, Chai-An, Wang, Steven W, Pan, Ping, Klein, William H

“…Retinal progenitor cells (RPCs) express basic helix-loop-helix (bHLH) factors in a strikingly mosaic spatiotemporal pattern, which is thought to contribute to…”
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A gene regulatory hierarchy for retinal ganglion cell specification and differentiation by Mu, Xiuqian, Klein, William H.

“…Retinal ganglion cells (RGCs) are the first cell type to be specified during vertebrate retinogenesis. Specification and differentiation of the RGC lineage are…”
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