Search Results - "Klein, S P"

Cerebrovascular Autoregulation Monitoring in the Management of Adult Severe Traumatic Brain Injury: A Delphi Consensus of Clinicians by Depreitere, B., Citerio, G., Smith, M., Adelson, P. David, Aries, M. J., Bleck, T. P., Bouzat, P., Chesnut, R., De Sloovere, V., Diringer, M., Dureanteau, J., Ercole, A., Hawryluk, G., Hawthorne, C., Helbok, R., Klein, S. P., Neumann, J. O., Robba, C., Steiner, L., Stocchetti, N., Taccone, F. S., Valadka, A., Wolf, S., Zeiler, F. A., Meyfroidt, G.

“…Background Several methods have been proposed to measure cerebrovascular autoregulation (CA) in traumatic brain injury (TBI), but the lack of a gold standard…”
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Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1 by BENZENO, S, LU, F, GUO, M, BARBASH, O, ZHANG, F, HERMAN, J. G, KLEIN, P. S, RUSTGI, A, DIEHL, J. A

“…Although cyclin D1 is overexpressed in a significant number of human cancers, overexpression alone is insufficient to promote tumorigenesis. In vitro studies…”
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Molecular targets of lithium action by Phiel, C J, Klein, P S

“…Lithium is highly effective in the treatment of bipolar disorder and also has multiple effects on embryonic development, glycogen synthesis, hematopoiesis, and…”
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A Molecular Mechanism for the Effect of Lithium on Development by Klein, Peter S., Melton, Douglas A.

“…Lithium, one of the most effective drugs for the treatment of bipolar (manic-depressive) disorder, also has dramatic effects on morphogenesis in the early…”
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Autoregulation assessment by direct visualisation of pial arterial blood flow in the piglet brain by Klein, S. P., De Sloovere, V., Meyfroidt, G., Depreitere, B.

“…Impairment of cerebrovascular autoregulation (CAR) is common after brain injury, although the pathophysiology remains elusive. The mechanisms of vascular…”
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Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo by Gurvich, Nadia, Berman, Melissa G, Wittner, Ben S, Gentleman, Robert C, Klein, Peter S, Green, Jeremy B. A

“…ABSTRACTChemically induced birth defects are an important public health and human problem. Here we use Xenopus and zebrafish as models to investigate the…”
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A role for frizzled 3 in neural crest development by Deardorff, M A, Tan, C, Saint-Jeannet, J P, Klein, P S

“…Wnts are a large family of secreted molecules implicated in numerous developmental processes. Frizzled proteins are likely receptors for Wnts and are required…”
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The use of computers in kindergarten, with or without adult mediation; effects on children's cognitive performance and behavior by Klein, P.S, Nir-Gal, O, Darom, E

“…This study was designed to examine the differential effects of three types of adult interaction with kindergarten children using computers on children's…”
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Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3 by Zhang, Fang, Phiel, Christopher J, Spece, Laura, Gurvich, Nadia, Klein, Peter S

“…Glycogen synthase kinase-3 (GSK-3) is a critical, negative regulator of diverse signaling pathways. Lithium is a direct inhibitor of GSK-3 and has been widely…”
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Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen by Phiel, Christopher J., Zhang, Fang, Huang, Eric Y., Guenther, Matthew G., Lazar, Mitchell A., Klein, Peter S.

“…Valproic acid is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its mechanisms of action in any of these settings are…”
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Hormonal regulation of embryogenesis: the formation of mesoderm in Xenopus laevis by Klein, P S, Melton, D A

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A Chemoattractant Receptor Controls Development in Dictyostelium discoideum by Klein, Peter S., Sun, Tzeli J., Saxe, Charles L., Kimmel, Alan R., Johnson, Ronald L., Devreotes, Peter N.

“…During the early stages of its developmental program, Dictyostelium discoideum expresses cell surface cyclic adenosine monophosphate (cyclic AMP) receptors. It…”
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Induction of Mesoderm in Xenopus laevis Embryos by Translation Initiation Factor 4E by Klein, Peter S., Melton, Douglas A.

“…The microinjection of messenger RNA encoding the eukaryotic translation initiation factor 4E (eIF-4E) into early embryos of Xenopus laevis leads to the…”
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Neural crest induction by the canonical Wnt pathway can be dissociated from anterior–posterior neural patterning in Xenopus by Wu, Jinling, Yang, Jing, Klein, Peter S.

“…While Wnt signaling is known to be involved in early steps of neural crest development, the mechanism remains unclear. Because Wnt signaling is able to…”
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Beta-catenin/Tcf-regulated transcription prior to the midblastula transition by Yang, Jing, Tan, Change, Darken, Rachel S, Wilson, Paul A, Klein, Peter S

“…Following fertilization, the zygotic genome in many organisms is quiescent until the midblastula transition (MBT), when large-scale transcription begins. In…”
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PP2A:B56ϵ is required for Wnt/β-catenin signaling during embryonic development by Yang, Jing, Wu, Jinling, Tan, Change, Klein, Peter S.

“…The Wnt/β-catenin pathway plays important roles during embryonic development and growth control. The B56 regulatory subunit of protein phosphatase 2A (PP2A)…”
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Wnt–frizzled signaling in neural crest formation by Wu, Jinling, Saint-Jeannet, Jean-Pierre, Klein, Peter S

“…The neural crest is a unique embryonic structure composed of a migratory population of multipotent cells. It is induced at the border of neural and epidermal…”
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Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3 by Hong, Ming, Chen, Daniel C.R., Klein, Peter S., Lee, Virginia M.-Y.

“…Lithium is one of the most widely used drugs for treating bipolar (manic-depressive) disorder. Despite its efficacy, the molecular mechanism underlying its…”
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Activation of the Wnt Signaling Pathway: A Molecular Mechanism for Lithium Action by Hedgepeth, Chester M., Conrad, Leslee J., Zhang, Jie, Huang, Hui-Chuan, Lee, Virginia M.Y., Klein, Peter S.

“…Glycogen synthase kinase-3β (GSK-3β/zeste-white-3/shaggy) is a negative regulator of the wnt signaling pathway which plays a central role in the development of…”
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Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis by Rothbächer, Ute, Laurent, Micheline N., Deardorff, Matthew A., Klein, Peter S., Cho, Ken W.Y., Fraser, Scott E.

“…Dishevelled (Dsh) induces a secondary axis and can translocate to the membrane when activated by Frizzleds; however, dominant‐negative approaches have not…”
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