Search Results - "Klein, Rüdiger"

Mechanisms of ephrin–Eph signalling in development, physiology and disease by Kania, Artur, Klein, Rüdiger

“…Key Points Eph Tyr kinases and ephrins can simultaneously act as receptors and ligands, allowing unidirectional or bidirectional signalling, which in turn can…”
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Bidirectional modulation of synaptic functions by Eph/ephrin signaling by Klein, Rüdiger

“…Ephrin ligands and their cognate Eph receptors guide axons during neural development and regulate synapse formation and neuronal plasticity in the adult…”
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Editorial – Friedrich Bonhoeffer (1932–2021) by Klein, Rüdiger, Wilkinson, David, Herrera, Eloisa

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Structural Perspectives on Axon Guidance by Seiradake, Elena, Jones, E. Yvonne, Klein, Rüdiger

“…Axon guidance relies on a combinatorial code of receptor and ligand interactions that direct adhesive attractive and repulsive cellular responses. Recent…”
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Bidirectional Eph–ephrin signaling during axon guidance by Egea, Joaquim, Klein, Rüdiger

“…Ephrins are cell-surface tethered guidance cues that bind to Eph receptor tyrosine kinases in trans on opposing cells. In the developing nervous system, the…”
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Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction by Lim, Hansol, Zhang, Yue, Peters, Christian, Straub, Tobias, Mayer, Johanna Luise, Klein, Rüdiger

“…The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate…”
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Nausea-induced suppression of feeding is mediated by central amygdala Dlk1-expressing neurons by Ding, Wenyu, Weltzien, Helena, Peters, Christian, Klein, Rüdiger

“…The motivation to eat is suppressed by satiety and aversive stimuli such as nausea. The neural circuit mechanisms of appetite suppression by nausea are not…”
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Mechanisms and functions of eph and ephrin signalling by Kullander, Klas, Klein, Rüdiger

“…Eph receptors constitute the largest family of tyrosine kinase receptors and, together with their plasma-membrane-bound ephrin ligands, have many important…”
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Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance by Gong, Jingyi, Körner, Roman, Gaitanos, Louise, Klein, Rüdiger

“…The cellular release of membranous vesicles known as extracellular vesicles (EVs) or exosomes represents a novel mode of intercellular communication. Eph…”
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In Situ Architecture and Cellular Interactions of PolyQ Inclusions by Bäuerlein, Felix J.B., Saha, Itika, Mishra, Archana, Kalemanov, Maria, Martínez-Sánchez, Antonio, Klein, Rüdiger, Dudanova, Irina, Hipp, Mark S., Hartl, F. Ulrich, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén

“…Expression of many disease-related aggregation-prone proteins results in cytotoxicity and the formation of large intracellular inclusion bodies. To gain…”
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Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules by del Toro, Daniel, Ruff, Tobias, Cederfjäll, Erik, Villalba, Ana, Seyit-Bremer, Gönül, Borrell, Víctor, Klein, Rüdiger

“…The folding of the mammalian cerebral cortex into sulci and gyri is thought to be favored by the amplification of basal progenitor cells and their tangential…”
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Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons by del Toro, Daniel, Carrasquero-Ordaz, Maria A., Chu, Amy, Ruff, Tobias, Shahin, Meriam, Jackson, Verity A., Chavent, Matthieu, Berbeira-Santana, Miguel, Seyit-Bremer, Goenuel, Brignani, Sara, Kaufmann, Rainer, Lowe, Edward, Klein, Rüdiger, Seiradake, Elena

“…Teneurins are ancient metazoan cell adhesion receptors that control brain development and neuronal wiring in higher animals. The extracellular C terminus binds…”
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FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development by Fleitas, Catherine, Marfull-Oromí, Pau, Chauhan, Disha, Del Toro, Daniel, Peguera, Blanca, Zammou, Bahira, Rocandio, Daniel, Klein, Rüdiger, Espinet, Carme, Egea, Joaquim

“…Neuron migration is a hallmark of nervous system development that allows gathering of neurons from different origins for assembling of functional neuronal…”
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Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function by Palmer, Amparo, Klein, Rudiger

“…One subclass of ephrins, the ephrinB ligands, are transmembrane proteins with intrinsic (so-called reverse) signaling properties (for review, see Kullander and…”
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Super-complexes of adhesion GPCRs and neural guidance receptors by Jackson, Verity A., Mehmood, Shahid, Chavent, Matthieu, Roversi, Pietro, Carrasquero, Maria, del Toro, Daniel, Seyit-Bremer, Goenuel, Ranaivoson, Fanomezana M., Comoletti, Davide, Sansom, Mark S. P., Robinson, Carol V., Klein, Rüdiger, Seiradake, Elena

“…Latrophilin adhesion-GPCRs (Lphn1–3 or ADGRL1–3) and Unc5 cell guidance receptors (Unc5A–D) interact with FLRT proteins (FLRT1–3), thereby promoting cell…”
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Work and Employment Situation of People with Mental Illness Receiving Independent Supported Housing: An Analysis of Routine Data from a Community Psychiatry Service by Dehn, Lorenz B, Suer, Julia, Klein, Rüdiger, Driessen, Martin

“…Due to insufficient empirical data on the occupational participation of people affected by severe mental illness receiving integration assistance, routine data…”
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Structurally encoded intraclass differences in EphA clusters drive distinct cell responses by Seiradake, Elena, Schaupp, Andreas, del Toro Ruiz, Daniel, Kaufmann, Rainer, Mitakidis, Nikolaos, Harlos, Karl, Aricescu, A Radu, Klein, Rüdiger, Jones, E Yvonne

“…Given the high degree of similarity between Eph receptors, it has remained unclear how the same ligand can produce different signaling outcomes. The crystal…”
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c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling by Fontana, Xavier, Hristova, Mariya, Da Costa, Clive, Patodia, Smriti, Thei, Laura, Makwana, Milan, Spencer-Dene, Bradley, Latouche, Morwena, Mirsky, Rhona, Jessen, Kristjan R, Klein, Rüdiger, Raivich, Gennadij, Behrens, Axel

“…The AP-1 transcription factor c-Jun is a master regulator of the axonal response in neurons. c-Jun also functions as a negative regulator of myelination in…”
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Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism by Kappeler, Laurent, De Magalhaes Filho, Carlos, Dupont, Joëlle, Leneuve, Patricia, Cervera, Pascale, Périn, Laurence, Loudes, Catherine, Blaise, Annick, Klein, Rüdiger, Epelbaum, Jacques, Le Bouc, Yves, Holzenberger, Martin

“…Mutations that decrease insulin-like growth factor (IGF) and growth hormone signaling limit body size and prolong lifespan in mice. In vertebrates, these…”
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Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development by Gong, Jingyi, Gaitanos, Thomas N, Luu, Olivia, Huang, Yunyun, Gaitanos, Louise, Lindner, Jana, Winklbauer, Rudolf, Klein, Rüdiger

“…Trogocytosis, in which cells nibble away parts of neighboring cells, is an intercellular cannibalism process conserved from protozoa to mammals. Its underlying…”
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