Search Results - "Klein, Peter M."

Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis by van Vught, Lonneke A, Klein Klouwenberg, Peter M. C, Spitoni, Cristian, Scicluna, Brendon P, Wiewel, Maryse A, Horn, Janneke, Schultz, Marcus J, Nürnberg, Peter, Bonten, Marc J. M, Cremer, Olaf L, van der Poll, Tom

“…IMPORTANCE: Sepsis is considered to induce immune suppression, leading to increased susceptibility to secondary infections with associated late mortality…”
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Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study by Klein Klouwenberg, Peter M C, Cremer, Olaf L, van Vught, Lonneke A, Ong, David S Y, Frencken, Jos F, Schultz, Marcus J, Bonten, Marc J, van der Poll, Tom

“…A clinical suspicion of infection is mandatory for diagnosing sepsis in patients with a systemic inflammatory response syndrome. Yet, the accuracy of…”
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Benzodiazepine-associated delirium in critically ill adults by Zaal, Irene J., Devlin, John W., Hazelbag, Marijn, Klein Klouwenberg, Peter M. C., van der Kooi, Arendina W., Ong, David S. Y., Cremer, Olaf L., Groenwold, Rolf H., Slooter, Arjen J. C.

“…Purpose The association between benzodiazepine use and delirium risk in the ICU remains unclear. Prior investigations have failed to account for disease…”
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Electronic Implementation of a Novel Surveillance Paradigm for Ventilator-associated Events: Feasibility and Validation by KLEIN KLOUWENBERG, Peter M. C, VAN MOURIK, Maaike S. M, ONG, David S. Y, HORN, Janneke, SCHULTZ, Marcus J, CREMER, Olaf L, BONTEN, Marc J. M

“…Accurate surveillance of ventilator-associated pneumonia (VAP) is hampered by subjective diagnostic criteria. A novel surveillance paradigm for…”
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Alternating sources of perisomatic inhibition during behavior by Dudok, Barna, Klein, Peter M., Hwaun, Ernie, Lee, Brian R., Yao, Zizhen, Fong, Olivia, Bowler, John C., Terada, Satoshi, Sparks, Fraser T., Szabo, Gergely G., Farrell, Jordan S., Berg, Jim, Daigle, Tanya L., Tasic, Bosiljka, Dimidschstein, Jordane, Fishell, Gord, Losonczy, Attila, Zeng, Hongkui, Soltesz, Ivan

“…Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key GABAergic controllers of hippocampal pyramidal cell output. Although the…”
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A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission by Scicluna, Brendon P, Klein Klouwenberg, Peter M C, van Vught, Lonneke A, Wiewel, Maryse A, Ong, David S Y, Zwinderman, Aeilko H, Franitza, Marek, Toliat, Mohammad R, Nürnberg, Peter, Hoogendijk, Arie J, Horn, Janneke, Cremer, Olaf L, Schultz, Marcus J, Bonten, Marc J, van der Poll, Tom

“…Community-acquired pneumonia (CAP) accounts for a major proportion of intensive care unit (ICU) admissions for respiratory failure and sepsis. Diagnostic…”
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A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts by McHugh, Leo, Seldon, Therese A, Brandon, Roslyn A, Kirk, James T, Rapisarda, Antony, Sutherland, Allison J, Presneill, Jeffrey J, Venter, Deon J, Lipman, Jeffrey, Thomas, Mervyn R, Klein Klouwenberg, Peter M C, van Vught, Lonneke, Scicluna, Brendon, Bonten, Marc, Cremer, Olaf L, Schultz, Marcus J, van der Poll, Tom, Yager, Thomas D, Brandon, Richard B

“…Systemic inflammation is a whole body reaction having an infection-positive (i.e., sepsis) or infection-negative origin. It is important to distinguish between…”
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The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway by Talos, Delia M, Sun, Hongyu, Zhou, Xiangping, Fitzgerald, Erin C, Jackson, Michele C, Klein, Peter M, Lan, Victor J, Joseph, Annelise, Jensen, Frances E

“…Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, and conversely epilepsy is common in autistic…”
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Epidemiology of Multiple Herpes Viremia in Previously Immunocompetent Patients With Septic Shock by Ong, David S. Y., Bonten, Marc J. M., Spitoni, Cristian, Lunel, Frans M. Verduyn, Frencken, Jos F., Horn, Janneke, Schultz, Marcus J., van der Poll, Tom, Klouwenberg, Peter M. C. Klein, Cremer, Olaf L.

“…Background. Systemic reactivations of herpesviruses may occur in intensive care unit (ICU) patients, even in those without prior immune deficiency. However,…”
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Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome by Ong, David S. Y., Spitoni, Cristian, Klein Klouwenberg, Peter M. C., Verduyn Lunel, Frans M., Frencken, Jos F., Schultz, Marcus J., van der Poll, Tom, Kesecioglu, Jozef, Bonten, Marc J. M., Cremer, Olaf L.

“…Purpose Cytomegalovirus (CMV) reactivation occurs frequently in patients with the acute respiratory distress syndrome (ARDS) and has been associated with…”
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Classification of sepsis, severe sepsis and septic shock: the impact of minor variations in data capture and definition of SIRS criteria by Klein Klouwenberg, Peter M. C., Ong, David S. Y., Bonten, Marc J. M., Cremer, Olaf L.

“…Purpose To quantify the effects of minor variations in the definition and measurement of systemic inflammatory response syndrome (SIRS) criteria and organ…”
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Supramammillary regulation of locomotion and hippocampal activity by Farrell, Jordan S, Lovett-Barron, Matthew, Klein, Peter M, Sparks, Fraser T, Gschwind, Tilo, Ortiz, Anna L, Ahanonu, Biafra, Bradbury, Susanna, Terada, Satoshi, Oijala, Mikko, Hwaun, Ernie, Dudok, Barna, Szabo, Gergely, Schnitzer, Mark J, Deisseroth, Karl, Losonczy, Attila, Soltesz, Ivan

“…Locomotor speed is a basic input used to calculate one’s position, but where this signal comes from is unclear. We identified neurons in the supramammillary…”
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Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice by Nguyen, Quynh-Anh, Klein, Peter M., Xie, Cheng, Benthall, Katelyn N., Iafrati, Jillian, Homidan, Jesslyn, Bendor, Jacob T., Dudok, Barna, Farrell, Jordan S., Gschwind, Tilo, Porter, Charlotte L., Keravala, Annahita, Dodson, G. Steven, Soltesz, Ivan

“…Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient…”
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Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients by van Vught, Lonneke A, Scicluna, Brendon P, Wiewel, Maryse A, Hoogendijk, Arie J, Klein Klouwenberg, Peter M C, Franitza, Marek, Toliat, Mohammad R, Nürnberg, Peter, Cremer, Olaf L, Horn, Janneke, Schultz, Marcus J, Bonten, Marc M J, van der Poll, Tom

“…Preclinical studies suggest that hospitalized patients are susceptible to infections caused by nosocomial respiratory pathogens at least in part because of…”
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Detrimental impacts of mixed-ion radiation on nervous system function by Klein, Peter M., Parihar, Vipan K., Szabo, Gergely G., Zöldi, Miklós, Angulo, Maria C., Allen, Barrett D., Amin, Amal N., Nguyen, Quynh-Anh, Katona, István, Baulch, Janet E., Limoli, Charles L., Soltesz, Ivan

“…Galactic cosmic radiation (GCR), composed of highly energetic and fully ionized atomic nuclei, produces diverse deleterious effects on the body. In researching…”
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Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis by Wiewel, Maryse A., de Stoppelaar, Sacha F., van Vught, Lonneke A., Frencken, Jos F., Hoogendijk, Arie J., Klein Klouwenberg, Peter M. C., Horn, Janneke, Bonten, Marc J., Zwinderman, Aeilko H., Cremer, Olaf L., Schultz, Marcus J., van der Poll, Tom

“…Purpose Sepsis is a major health burden worldwide. Preclinical investigations in animals and retrospective studies in patients have suggested that inhibition…”
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Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes by Guagliardo, Nick A., Klein, Peter M., Gancayco, Christina A., Lu, Adam, Leng, Sining, Makarem, Rany R., Cho, Chelsea, Rusin, Craig G., Breault, David T., Barrett, Paula Q., Beenhakker, Mark P.

“…Aldosterone-producing zona glomerulosa (zG) cells of the adrenal gland arrange in distinct multi-cellular rosettes that provide a structural framework for…”
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Tenuous Inhibitory GABAergic Signaling in the Reticular Thalamus by Klein, Peter M, Lu, Adam C, Harper, Megan E, McKown, Hannah M, Morgan, Jessica D, Beenhakker, Mark P

“…Maintenance of a low intracellular Cl concentration ([Cl ] ) is critical for enabling inhibitory neuronal responses to GABA receptor-mediated signaling. Cl…”
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Development of later life spontaneous seizures in a rodent model of hypoxia‐induced neonatal seizures by Rakhade, Sanjay N., Klein, Peter M., Huynh, Thanthao, Hilario‐Gomez, Cristina, Kosaras, Bela, Rotenberg, Alexander, Jensen, Frances E.

“…Summary Purpose:  To study the development of epilepsy following hypoxia‐induced neonatal seizures in Long‐Evans rats and to establish the presence of…”
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Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures by Sun, Hongyu, Kosaras, Bela, Klein, Peter M., Jensen, Frances E.

“…Homeostatic plasticity is characterized by compensatory changes in synaptic strength and intrinsic membrane properties in response to chronic changes in…”
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