Search Results - "Klein, L"

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases by Klein, Sabra L.

“…The intensity and prevalence of viral infections are typically higher in males, whereas disease outcome can be worse for females. Females mount higher innate…”
Get full text

Sex Differences in Immunity to Viral Infections by Jacobsen, Henning, Klein, Sabra L

“…The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following SARS-CoV-2 infection. Strong evidence…”
Get full text

Considering how biological sex impacts immune responses and COVID-19 outcomes by Scully, Eileen P., Haverfield, Jenna, Ursin, Rebecca L., Tannenbaum, Cara, Klein, Sabra L.

“…A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with the pathogenesis of other viral infections. Biological sex differences…”
Get full text

Host Factors Impact Vaccine Efficacy: Implications for Seasonal and Universal Influenza Vaccine Programs by Dhakal, Santosh, Klein, Sabra L

“…Influenza is a global public health problem. Current seasonal influenza vaccines have highly variable efficacy, and thus attempts to develop broadly protective…”
Get full text

SeXX Matters in Infectious Disease Pathogenesis by vom Steeg, Landon G, Klein, Sabra L

“…  A future challenge will be to interpret immunological differences between the sexes in the context of infectious disease pathogenesis.\n The binding of sex…”
Get full text

Using collective variables to drive molecular dynamics simulations by Fiorin, Giacomo, Klein, Michael L., Hénin, Jérôme

“…A software framework is introduced that facilitates the application of biasing algorithms to collective variables of the type commonly employed to drive…”
Get full text

The impact of sex and gender on immunotherapy outcomes by Klein, Sabra L, Morgan, Rosemary

“…Immunotherapies are often used for the treatment, remission, and possible cure of autoimmune diseases, infectious diseases, and cancers. Empirical evidence…”
Get full text

Sex-based Biology and the Rational Design of Influenza Vaccination Strategies by Klein, Sabra L., Pekosz, Andrew

“…Biological (ie, sex) differences as well as cultural (ie, gender) norms influence the acceptance and efficacy of vaccines for males and females. These…”
Get full text

Impact of sex and gender on COVID-19 outcomes in Europe by Gebhard, Catherine, Regitz-Zagrosek, Vera, Neuhauser, Hannelore K, Morgan, Rosemary, Klein, Sabra L

“…Emerging evidence from China suggests that coronavirus disease 2019 (COVID-19) is deadlier for infected men than women with a 2.8% fatality rate being reported…”
Get full text

Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis by Robinson, Dionne P., Klein, Sabra L.

“…This article is part of a Special Issue “Neuroendocrine-Immune Axis in Health and Disease.” During pregnancy, it is evolutionarily advantageous for…”
Get full text

Biological sex impacts COVID-19 outcomes by Klein, Sabra L, Dhakal, Santosh, Ursin, Rebecca L, Deshpande, Sharvari, Sandberg, Kathryn, Mauvais-Jarvis, Franck

“…The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the…”
Get full text

Sex and Gender Differences in the Outcomes of Vaccination over the Life Course by Flanagan, Katie L, Fink, Ashley L, Plebanski, Magdalena, Klein, Sabra L

“…Both sex (i.e., biological differences) and gender (i.e., social or cultural influences) impact vaccine acceptance, responses, and outcomes. Clinical data…”
Get full text

Transforming Growth Factor-Beta in Skeletal Muscle Wasting by Klein, Gordon L

“…Transforming growth factor-beta (TGF-β) is part of a family of molecules that is present in many body tissues and performs many different functions. Evidence…”
Get full text

Sexual Harassment of College and University Students: A Systematic Review by Klein, L. B., Martin, Sandra L.

“…Increased attention to Title IX and the #MeToo movement has led to more interest in developing strategies to prevent forms of gender-based violence beyond…”
Get full text

Phosphate as an adjunct to calcium in promoting coronary vascular calcification in chronic inflammatory states by Klein, Gordon L

“…Bone releases calcium and phosphate in response to pro-inflammatory cytokine-mediated inflammation. The body develops impaired urinary excretion of phosphate…”
Get full text

Is calcium a link between inflammatory bone resorption and heart disease? by Klein, Gordon L

“…Several epidemiologic studies associate bone-resorbing chronic inflammatory conditions with increased risk of atherosclerotic heart disease. These include…”
Get full text

Biological sex affects vaccine efficacy and protection against influenza in mice by Fink, Ashley L., Engle, Kyrra, Ursin, Rebecca L., Tang, Wan-Yee, Klein, Sabra L.

“…Biological sex affects adaptive immune responses, which could impact influenza infection and vaccine efficacy. Infection of mice with 2009 H1N1 induced…”
Get full text

The Xs and Y of immune responses to viral vaccines by Klein, Sabra L, Dr, Jedlicka, Anne, MS, Pekosz, Andrew, PhD

“…Summary The biological differences associated with the sex of an individual are a major source of variation, affecting immune responses to vaccination…”
Get full text

The consequences of Rad51 overexpression for normal and tumor cells by Klein, Hannah L.

“…The Rad51 recombinase is an essential factor for homologous recombination and the repair of DNA double strand breaks, binding transiently to both single…”
Get full text

Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging by Nagueh, Sherif F., MD, FASE, Smiseth, Otto A., MD, PhD, Appleton, Christopher P., MD, Byrd, Benjamin F., MD, FASE, Dokainish, Hisham, MD, FASE, Edvardsen, Thor, MD, PhD, Flachskampf, Frank A., MD, PhD, FESC, Gillebert, Thierry C., MD, PhD, FESC, Klein, Allan L., MD, FASE, Lancellotti, Patrizio, MD, PhD, FESC, Marino, Paolo, MD, FESC, Oh, Jae K., MD, Popescu, Bogdan Alexandru, MD, PhD, FESC, FASE, Waggoner, Alan D., MHS, RDCS

Get full text