Search Results - "Klein, Kevin C."

HIV Gag-Leucine Zipper Chimeras Form ABCE1-Containing Intermediates and RNase-Resistant Immature Capsids Similar to Those Formed by Wild-Type HIV-1 Gag by KLEIN, Kevin C, REED, Jonathan C, TANAKA, Motoko, NGUYEN, Veronica T, GIRI, Samina, LINGAPPA, Jaisri R

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Basic Residues in the Nucleocapsid Domain of Gag Are Required for Interaction of HIV-1 Gag with ABCE1 (HP68), a Cellular Protein Important for HIV-1 Capsid Assembly by Lingappa, Jaisri R., Dooher, Julia E., Newman, Michael A., Kiser, Patti K., Klein, Kevin C.

“…During human immunodeficiency virus, type 1 (HIV-1) assembly, Gag polypeptides multimerize into immature HIV-1 capsids. The cellular ATP-binding protein ABCE1…”
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Identification of a host protein essential for assembly of immature HIV-1 capsids by Lingappa, Jaisri R, Zimmerman, Concepcion, Klein, Kevin C, Kiser, Patti K, Singh, Aalok R, Firestein, Bonnie L, Riba, Shannyn C

“…To form an immature HIV-1 capsid, 1,500 HIV-1 Gag (p55) polypeptides must assemble properly along the host cell plasma membrane. Insect cells and many higher…”
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Unique Features of Hepatitis C Virus Capsid Formation Revealed by De Novo Cell-Free Assembly by KLEIN, Kevin C, POLYAK, Stephen J, LINGAPPA, Jaisri R

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Identification of Residues in the Hepatitis C Virus Core Protein That Are Critical for Capsid Assembly in a Cell-Free System by KLEIN, Kevin C, DELLOS, Sheri R, LINGAPPA, Jaisri R

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T cells contain an RNase-insensitive inhibitor of APOBEC3G deaminase activity by Thielen, Beth K, Klein, Kevin C, Walker, Lorne W, Rieck, Mary, Buckner, Jane H, Tomblingson, Garrett W, Lingappa, Jaisri R

“…The deoxycytidine deaminase APOBEC3G (A3G) is expressed in human T cells and inhibits HIV-1 replication. When transfected into A3G-deficient epithelial cell…”
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HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly by Reed, Jonathan C, Molter, Britta, Geary, Clair D, McNevin, John, McElrath, Julie, Giri, Samina, Klein, Kevin C, Lingappa, Jaisri R

“…To produce progeny virus, human immunodeficiency virus type I (HIV-1) Gag assembles into capsids that package the viral genome and bud from the infected cell…”
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Antiviral Function of APOBEC3G Can Be Dissociated from Cytidine Deaminase Activity by Newman, Edmund N.C., Holmes, Rebecca K., Craig, Heather M., Klein, Kevin C., Lingappa, Jaisri R., Malim, Michael H., Sheehy, Ann M.

“…The antiretroviral activity of the cellular enzyme APOBEC3G [1] has been attributed to the excessive deamination of cytidine (C) to uridine (U) in minus strand…”
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Innate Immune Signaling Induces High Levels of TC-specific Deaminase Activity in Primary Monocyte-derived Cells through Expression of APOBEC3A Isoforms by Thielen, Beth K., McNevin, John P., McElrath, M. Juliana, Hunt, Brook Vander Stoep, Klein, Kevin C., Lingappa, Jaisri R.

“…In HIV-1-infected individuals, G-to-A hypermutation is found in HIV-1 DNA isolated from peripheral blood mononuclear cells (PBMCs). These mutations are thought…”
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Intracellular destinies: degradation, targeting, assembly, and endocytosis of HIV Gag by Klein, Kevin C, Reed, Jonathan C, Lingappa, Jaisri R

“…The HIV-1 Gag protein assembles into immature capsids when expressed in human cells. Although self-assembly of Gag was once thought to be sufficient to explain…”
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Comparing capsid assembly of primate lentiviruses and hepatitis B virus using cell-free systems by Lingappa, Jaisri R., Newman, Michael A., Klein, Kevin C., Dooher, Julia E.

“…Many viruses that assemble their capsids in the eukaryotic cytoplasm require a threshold concentration of capsid protein to achieve capsid assembly. Strategies…”
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Identification of Residues in the Hepatitis C Virus Core Protein That Are Critical for Capsid Assembly in a Cell-Free System by Klein, Kevin C., Dellos, Sheri R., Lingappa, Jaisri R.

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