Search Results - "Klein, Joshua G."

Widening the bottleneck: Heterologous expression, purification, and characterization of the Ktedonobacter racemifer minimal type II polyketide synthase in Escherichia coli by Klein, Joshua G., Wu, Yang, Kokona, Bashkim, Charkoudian, Louise K.

“…[Display omitted] Enzyme assemblies such as type II polyketide synthases (PKSs) produce a wide array of bioactive secondary metabolites. While the molecules…”
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Genome Engineering Human ESCs or iPSCs with Cytosine and Adenine Base Editors by Pavani, Giulia, Klein, Joshua G, French, Deborah L, Gadue, Paul

“…The ability to engineer specific mutations in human embryonic stem cells (ECSs) or induced pluripotent stem cells (iPSCs) is extremely important in the…”
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Musculoskeletal CT Imaging: State-of-the-Art Advancements and Future Directions by Demehri, Shadpour, Baffour, Francis I, Klein, Joshua G, Ghotbi, Elena, Ibad, Hamza Ahmed, Moradi, Kamyar, Taguchi, Katsuyuki, Fritz, Jan, Carrino, John A, Guermazi, Ali, Fishman, Elliot K, Zbijewski, Wojciech B

“…CT is one of the most widely used modalities for musculoskeletal imaging. Recent advancements in the field include the introduction of four-dimensional CT,…”
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CT-derived pectoralis composition and incident pneumonia hospitalization using fully automated deep-learning algorithm: multi-ethnic study of atherosclerosis by Ibad, Hamza A., Hathaway, Quincy A., Bluemke, David A., Kasaeian, Arta, Klein, Joshua G., Budoff, Matthew J., Barr, R. Graham, Allison, Matthew, Post, Wendy S., Lima, João A. C., Demehri, Shadpour

“…Background Pneumonia-related hospitalization may be associated with advanced skeletal muscle loss due to aging (i.e., sarcopenia) or chronic illnesses (i.e.,…”
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Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model by Borst, Sara, Nations, Catriana C., Klein, Joshua G., Pavani, Giulia, Maguire, Jean Ann, Camire, Rodney M., Drazer, Michael W., Godley, Lucy A., French, Deborah L., Poncz, Mortimer, Gadue, Paul

“…Inherited thrombocytopenia results in low platelet counts and increased bleeding. Subsets of these patients have monoallelic germline mutations in ETV6 or…”
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Modeling primitive and definitive erythropoiesis with induced pluripotent stem cells by Pavani, Giulia, Klein, Joshua G., Nations, Catriana C., Sussman, Jonathan H., Tan, Kai, An, Hyun Hyung, Abdulmalik, Osheiza, Thom, Christopher S., Gearhart, Peter A., Willett, Camryn M., Maguire, Jean Ann, Chou, Stella T., French, Deborah L., Gadue, Paul

“…•iPSC-derived primitive and definitive RBCs display different characteristics, red cell antigen expression, and disease-modeling capabilities.•Isogenic…”
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Predictive Value of Deep Learning-derived CT Pectoralis Muscle and Adipose Measurements for Incident Heart Failure: Multi-Ethnic Study of Atherosclerosis by Hathaway, Quincy, Ibad, Hamza Ahmed, Bluemke, David A, Pishgar, Farhad, Kasaiean, Arta, Klein, Joshua G, Cogswell, Rebecca, Allison, Matthew, Budoff, Matthew J, Barr, R Graham, Post, Wendy, Bredella, Miriam A, Lima, João A C, Demehri, Shadpour

“…To develop a deep learning algorithm capable of extracting pectoralis muscle and adipose measurements and to longitudinally investigate associations between…”
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Heterologous Expression and Characterization of Ancient Orphaned Type II Polyketide Synthase Enzymes by Klein, Joshua G., Kokona, Bashkim, Charkoudian, Louise K.

“…Abstract only Type II polyketides are polyaromatic bacterial secondary metabolites which have seen great success in the clinic. Doxorubicin and tetracycline…”
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Accessing new chemical diversity from ancient non‐actinobacterial strains by Terrell, Stephanie M., Wu, Yang, Klein, Joshua G., Charkoudian, Louise K.

“…Our work focuses on the discovery of new biosynthetic routes to chemical diversity through the characterization of unexplored polyketide synthase (PKS) gene…”
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ActinoBase: tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria by Feeney, Morgan Anne, Newitt, Jake Terry, Addington, Emily, Algora-Gallardo, Lis, Allan, Craig, Balis, Lucas, Birke, Anna S., Castaño-Espriu, Laia, Charkoudian, Louise K., Devine, Rebecca, Gayrard, Damien, Hamilton, Jacob, Hennrich, Oliver, Hoskisson, Paul A., Keith-Baker, Molly, Klein, Joshua G., Kruasuwan, Worarat, Mark, David R., Mast, Yvonne, McHugh, Rebecca E., McLean, Thomas C., Mohit, Elmira, Munnoch, John T., Murray, Jordan, Noble, Katie, Otani, Hiroshi, Parra, Jonathan, Pereira, Camila F., Perry, Louisa, Pintor-Escobar, Linamaria, Pritchard, Leighton, Prudence, Samuel M. M., Russell, Alicia H., Schniete, Jana K., Seipke, Ryan F., Sélem-Mojica, Nelly, Undabarrena, Agustina, Vind, Kristiina, van Wezel, Gilles P., Wilkinson, Barrie, Worsley, Sarah F., Duncan, Katherine R., Fernández-Martínez, Lorena T., Hutchings, Matthew I.

“…Actinobacteria is an ancient phylum of Gram-positive bacteria with a characteristic high GC content to their DNA. The ActinoBase Wiki is focused on the…”
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